Abstract
Sunlight induces actinic keratosis, skin cancers and photoaging. Photoprotection is thus a major issue in public health to prevent the harmful effects of solar ultraviolet (UV) radiations. Recent data have shown that the visible (VIS) and infrared (IR) radiations can lead to skin damage by oxidative stress, suggesting that a balanced protection across the entire spectrum of sunlight is necessary to prevent cutaneous alterations. In this context, we developed a new generation of sunfilter called Phenylene Bis-Diphenyltriazine or TriAsorB (CAS N°55514-22-2). The aim of the present study was to assess the photoprotective efficacy of TriAsorB from UV to IR light. Spectrophotometric assays were performed to measure absorption and reflectance of TriAsorB in the different spectral ranges of sunlight: UV, VIS including blue light or high energy visible (HEV) and IR. DNA damage was evaluated using reconstructed human epidermis (RHE): 8-hydroxy-2′-deoxyguanosine (8OHdG) in response to HEV exposure, pyrimidine dimers (CPDs) and (6-4) photoproducts following solar-simulated radiation (SSR). TriAsorB is a broad spectrum UVB + UVA filter including long UVA. Interestingly, it also absorbs VIS radiations, especially in the HEV region. These radiations are also reflected. Protection in the IR spectral range is weak. Furthermore, the sunfilter specifically protects the skin against the oxidative lesions 8OHdG induced by HEV and prevents SSR-induced DNA damage. Thus, TriAsorB is an innovative sunfilter that might be used in sun care products for skin photoprotection from UV to VIS radiations. Finally, it prevents sunlight genotoxicity and protected the skin against solar radiations, especially blue light.
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Abbreviations
- UV:
-
Ultraviolet light
- VIS:
-
Visible light
- HEV:
-
High energy visible light
- IR:
-
Infrared light
- SSR:
-
Solar-simulated radiation
- SCCS:
-
Scientific Committee on Consumer Safety
- CW:
-
Critical wavelength
- HPLC–MS/MS:
-
HPLC associated with tandem mass spectrometry
- 8OHdG:
-
8-Hydroxy-2′-deoxyguanosine
- CPD:
-
Cyclobutane pyrimidine dimer
- 64PP:
-
Pyrimidine (6-4) pyrimidone photoproducts
- DEW:
-
Dewar valence isomer
- ORS:
-
Outer root sheath
- RHE:
-
Reconstructed human epidermis
- ROS:
-
Reactive oxygen species
- INCI:
-
International Nomenclature of Cosmetic Ingredients
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Acknowledgements
We are grateful to the following colleagues for their help in experiments: L. Duprat, A. Tourette, Frédéric Crépel, V. Périer and L. Cattuzzato from Pierre Fabre Dermo-Cosmétique. We also thank V. Georgescu, A. Couttet, S. Saint André and C. Jean-Decoster from Avène laboratories, but also Alain Moga and Nicolas Almaric from Synelvia for performing blue light evaluation.
Funding
The reported studies were funded by Pierre Fabre Dermo-Cosmétique, France and Laboratoires Dermatologiques Avène.
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All authors except T. Douki are employees of Pierre Fabre group, France. The authors report no other conflicts of interest associated with this work.
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Bacqueville, D., Jacques-Jamin, C., Dromigny, H. et al. Phenylene Bis-Diphenyltriazine (TriAsorB), a new sunfilter protecting the skin against both UVB + UVA and blue light radiations. Photochem Photobiol Sci 20, 1475–1486 (2021). https://doi.org/10.1007/s43630-021-00114-x
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DOI: https://doi.org/10.1007/s43630-021-00114-x