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Presence of Endometrioma Does Not Impair Embryo Quality and Assisted Reproductive Technology (ART) Cycle Outcome in Diminished Ovarian Reserve (DOR) Patients

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Abstract

This study aims to assess the impact of endometrioma on embryo quality and cycle outcome in patients who undergo assisted reproductive technology (ART) treatment due to diminished ovarian reserve (DOR). Retrospective case–control study was conducted in women ≤ 40 years of age who underwent ART treatment caused by DOR, defined according to POSEIDON criteria, at a university-based infertility clinic between January 2015 and December 2020. Three groups of patients were selected: group A included patients with an idiopathic DOR, group B included patients with endometrioma(s) who underwent ovarian cystectomy, and group C included patients with endometrioma(s) without surgical treatment. A total of 351 women with DOR were included in the final analysis. Demographic characteristics, including age and AMH, were similar between the groups. Significant differences were observed among groups on mean number of MII oocytes retrieved (1.88 ± 1.59 vs. 2.84 ± 2.89 vs. 2.78 ± 2.41, respectively; p < 0.001) and mean number of embryos (1.04 ± 1.18 vs. 1.87 ± 2.01 vs. 1.66 ± 1.81, respectively; p < 0.001). However, the mean number of top-quality embryos, cycle cancellation, and live birth rates were similar between the groups. Clinical pregnancy (35 (26.5%) vs. 8 (18.2%) vs. 18 (42.9%), respectively; p = 0.038) and miscarriage rates (12 (9.1%) vs. 0 vs. 8 (19.0%), respectively; p = 0.009) were higher in endometrioma group without surgery. Women with DOR appear to have similar ART cycle outcomes regardless of the etiology, in terms of live birth rates. Infertility of endometrioma patients might be related to altered endometrium rather than to decreased oocyte quality. Cystectomy for endometrioma before IVF did not seem to affect the LBR.

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Authors and Affiliations

  1. Department of Gynaecology and Obstetrics, Ankara Medipol University Faculty of Medicine, Anafartalar Mh. Talatpaşa Blv, Biga 2 Sk No: 2, 06050, Ankara, Turkey

    Şeyma Osmanlıoğlu

  2. Department of Gynaecology and Obstetrics, Ankara University Faculty of Medicine, Ankara, Turkey

    Bülent Berker, Batuhan Aslan, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Cem Somer Atabekoğlu & Ruşen Aytaç

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  1. Şeyma Osmanlıoğlu
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Correspondence to Şeyma Osmanlıoğlu.

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Osmanlıoğlu, Ş., Berker, B., Aslan, B. et al. Presence of Endometrioma Does Not Impair Embryo Quality and Assisted Reproductive Technology (ART) Cycle Outcome in Diminished Ovarian Reserve (DOR) Patients. Reprod. Sci. 30, 1540–1547 (2023). https://doi.org/10.1007/s43032-022-01111-w

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