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Endometriosis Is Associated with Adverse Pregnancy Outcomes: a National Population-Based Study

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Abstract

Pregnancy and neonatal outcomes in women diagnosed with endometriosis were investigated using data collected from the Korea National Health Insurance Claims Database and the National Health Screening Program for Infants and Children. A total of 3,778,561 women who gave birth between 2007 and 2015 were identified, and 1,938,424 primiparous women and their newborns were included in this study. Women with a diagnosis of endometriosis had a significantly higher incidence of multiple pregnancy, cesarean section, breech presentation, postpartum hemorrhage, placental abruption, placenta previa, and stillbirth than women without endometriosis (P < 0.0001). The rates of preterm birth and low birth weight were also increased in women with endometriosis (P < 0.0001). After adjusting for age, the estimated risks of these outcomes remained significant. Women previously diagnosed with endometriosis have an increased risk of adverse pregnancy and neonatal outcomes. Particular attention and information regarding these conditions should be provided to women with endometriosis during the preconception or antenatal periods.

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Author notes

  1. Kyong Wook Yi and Geum Joon Cho contributed equally to this work.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, College of Medicine, Korea University, 73, Goryeodae-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea

    Kyong Wook Yi, Geum Joon Cho, Jung-Ho Shin, Tak Kim & Jun-Young Hur

  2. School of Industrial Management Engineering, Korea University, Seoul, Republic of Korea

    KeonVin Park & Sung Won Han

Authors
  1. Kyong Wook Yi
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  2. Geum Joon Cho
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  3. KeonVin Park
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  4. Sung Won Han
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  5. Jung-Ho Shin
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  6. Tak Kim
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  7. Jun-Young Hur
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Correspondence to Jun-Young Hur.

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This study protocol was approved by the Institutional Review Board of the Korea University Medical Center.

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The authors declare that they have no conflicts of interest.

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Yi, K.W., Cho, G.J., Park, K. et al. Endometriosis Is Associated with Adverse Pregnancy Outcomes: a National Population-Based Study. Reprod. Sci. 27, 1175–1180 (2020). https://doi.org/10.1007/s43032-019-00109-1

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  • DOI: https://doi.org/10.1007/s43032-019-00109-1

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