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Can Contraceptive Pill Affect Future Offspring’s Health? The Implications of Using Hormonal Birth Control for Human Evolution

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Abstract

Resistance to disease is greater for offspring if the parents have dissimilar immune systems, as their pathogen-detection ability is enhanced. Accordingly, women evolved to be sexually attracted to men with a dissimilar immune system, primarily during high-fertility cycle phases. Contraceptive pills, however, reverse women’s preferences, leading them to be attracted to men with a similar immune system. In the present study (N = 192), we compared the health of children born to parents who met while the mother was on the pill with that of children whose parents met when the mother was not on the pill. Results confirmed our predictions, indicating that children to mothers who were on the pill are more infection-prone, require more medical care, suffer from a higher frequency of common sicknesses, and are perceived as generally less healthy than children whose parents met on non-pill circumstances. Results are discussed in light of the current antibiotic world crisis.

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References

  • Adler, N. E., & Ostrove, J. M. (1999). Socioeconomic status and health: what we know and what we don’t. Annals of the New York Academy of Sciences, 896(1), 3–15.

    Article  PubMed  Google Scholar 

  • Aeschlimann, P., Häberli, M., Reusch, T., Boehm, T., & Milinski, M. (2003). Female sticklebacks Gasterosteus aculeatus use self-reference to optimize MHC allele number during mate selection. Behavioral Ecology and Sociobiology, 54(2), 119–126.

    Google Scholar 

  • Alvergne, A., & Lummaa, V. (2010). Does the contraceptive pill alter mate choice in humans? Trends in Ecology & Evolution, 25(3), 171–179.

    Article  Google Scholar 

  • Bertram, S. M., Loranger, M. J., Thomson, I. R., Harrison, S. J., Ferguson, G. L., Reifer, M. L.,…Gowaty, P. A. (2016). Linking mating preferences to sexually selected traits and offspring viability: good versus complementary genes hypotheses. Animal Behaviour, 119, 75-86.

  • Bonneaud, C., Chastel, O., Federici, P., Westerdahl, H., & Sorci, G. (2006). Complex Mhc-based mate choice in a wild passerine. Proceedings of the Royal Society of London B: Biological Sciences, 273(1590), 1111–1116.

    Article  Google Scholar 

  • Chaix, R., Cao, C., & Donnelly, P. (2008). Is mate choice in humans MHC-dependent? PLoS Genetics, 4(9), e1000184.

    Article  PubMed  PubMed Central  Google Scholar 

  • Faul, F., Erdfelder, E., Buchner, A., & Lang, A. G. (2009). Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behavior Research Methods, 41, 1149–1160.

    Article  PubMed  Google Scholar 

  • Feinberg, D., Jones, B., Smith, M. L., Moore, F. R., DeBruine, L. M., Cornwell, R.,…Perrett, D. (2006). Menstrual cycle, trait estrogen level, and masculinity preferences in the human voice. Hormones and Behavior, 49(2), 215-222.

  • Frost, P. (1994). Preference for darker faces in photographs at different phases of the menstrual cycle: preliminary assessment of evidence for a hormonal relationship. Perceptual and Motor Skills, 79(1), 507–514.

    Article  PubMed  Google Scholar 

  • Gangestad, S. W., & Cousins, A. J. (2001). Adaptive design, female mate preferences, and shifts across the menstrual cycle. Annual Review of Sex Research, 12(1), 145–185.

    PubMed  Google Scholar 

  • Gangestad, S. W., & Thornhill, R. (2008). Human oestrus. Proceedings of the Royal Society of London B: Biological Sciences, 275(1638), 991–1000.

    Article  Google Scholar 

  • Hay, A. D., Heron, J., Ness, A., & Team, A. S. (2005). The prevalence of symptoms and consultations in pre-school children in the Avon Longitudinal Study of Parents and Children (ALSPAC): a prospective cohort study. Family Practice, 22(4), 367–374.

    Article  PubMed  Google Scholar 

  • Hedrick, P. W., & Black, F. L. (1997). HLA and mate selection: no evidence in South Amerindians. The American Journal of Human Genetics, 61(3), 505–511.

    Article  PubMed  Google Scholar 

  • Idler, E. L., & Benyamini, Y. (1997). Self-rated health and mortality: a review of twenty-seven community studies. Journal of Health and Social Behavior, 38, 21–37.

    Article  PubMed  Google Scholar 

  • Jacob, S., McClintock, M. K., Zelano, B., & Ober, C. (2002). Paternally inherited HLA alleles are associated with women’s choice of male odor. Nature Genetics, 30(2), 175–179.

    Article  PubMed  Google Scholar 

  • Jacobsson, B., Ladfors, L., & Milsom, I. (2004). Advanced maternal age and adverse perinatal outcome. Obstetrics & Gynecology, 104(4), 727–733.

    Article  Google Scholar 

  • Johnston, V. S., Hagel, R., Franklin, M., Fink, B., & Grammer, K. (2001). Male facial attractiveness: evidence for hormone-mediated adaptive design. Evolution and Human Behavior, 22(4), 251–267.

    Article  Google Scholar 

  • Jones, B. C., Perrett, D. I., Little, A. C., Boothroyd, L., Cornwell, R., Feinberg, D.,…Hillier, S. (2005). Menstrual cycle, pregnancy and oral contraceptive use alter attraction to apparent health in faces. Proceedings of the Royal Society of London B: Biological Sciences, 272(1561), 347-354.

  • Jones, B. C., DeBruine, L. M., Perrett, D. I., Little, A. C., Feinberg, D. R., & Smith, M. J. L. (2008). Effects of menstrual cycle phase on face preferences. Archives of Sexual Behavior, 37(1), 78–84.

    Article  PubMed  Google Scholar 

  • Jones, J., Mosher, W., & Daniels, K. (2012). Current contraceptive use in the United States, 2006–2010, and changes in patterns of use since 1995. National Health Statistics Reports, 60, 1–25.

    Google Scholar 

  • Landry, C., Garant, D., Duchesne, P., & Bernatchez, L. (2001). ‘Good genes as heterozygosity’: the major histocompatibility complex and mate choice in Atlantic salmon (Salmo salar). Proceedings of the Royal Society of London B: Biological Sciences, 268(1473), 1279–1285.

    Article  Google Scholar 

  • Little, A. C., Jones, B. C., & Burriss, R. P. (2007). Preferences for masculinity in male bodies change across the menstrual cycle. Hormones and Behavior, 51(5), 633–639.

    Article  PubMed  Google Scholar 

  • Miller, G. A. & Chapman, J. P. (2001). Misunderstanding analysis of covariance. Journal of Abnormal Psychology, 110, 40–48.

  • Neff, B. D., & Pitcher, T. E. (2005). Genetic quality and sexual selection: an integrated framework for good genes and compatible genes. Molecular Ecology, 14(1), 19–38.

    Article  PubMed  Google Scholar 

  • Ober, C., Weitkamp, L. R., Cox, N., Dytch, H., Kostyu, D., & Elias, S. (1997). HLA and mate choice in humans. The American Journal of Human Genetics, 61(3), 497–504.

    Article  PubMed  Google Scholar 

  • Penn, D., & Potts, W. K. (1998). Untrained mice discriminate MHC-determined odors. Physiology & Behavior, 64(3), 235–243.

    Article  Google Scholar 

  • Penton-Voak, I. S., & Perrett, D. I. (2000). Female preference for male faces changes cyclically: further evidence. Evolution and Human Behavior, 21(1), 39–48.

    Article  Google Scholar 

  • Penton-Voak, I. S., Perrett, D. I., Castles, D. L., Kobayashi, T., Burt, D. M., Murray, L. K., & Minamisawa, R. (1999). Menstrual cycle alters face preference. Nature, 399(6738), 741–742.

    Article  PubMed  Google Scholar 

  • Potts, W. K., Manning, C. J., & Wakeland, E. K. (1991). Mating patterns in seminatural populations of mice influenced by MHC genotype.

  • Puts, D. A. (2005). Mating context and menstrual phase affect women’s preferences for male voice pitch. Evolution and Human Behavior, 26(5), 388–397.

    Article  Google Scholar 

  • Puts, D. A. (2006). Cyclic variation in women’s preferences for masculine traits. Human Nature, 17(1), 114–127.

    Article  PubMed  Google Scholar 

  • Richardson, D. S., Komdeur, J., Burke, T., & Von Schantz, T. (2005). MHC-based patterns of social and extra-pair mate choice in the Seychelles warbler. Proceedings of the Royal Society of London B: Biological Sciences, 272(1564), 759–767.

    Article  Google Scholar 

  • Roberts, S. C., Gosling, L. M., Carter, V., & Petrie, M. (2008). MHC-correlated odour preferences in humans and the use of oral contraceptives. Proceedings of the Royal Society of London B: Biological Sciences, 275(1652), 2715–2722.

    Article  Google Scholar 

  • Roberts, S. C., Cobey, K. D., Klapilová, K., & Havlíček, J. (2013). An evolutionary approach offers a fresh perspective on the relationship between oral contraception and sexual desire. Archives of Sexual Behavior, 42(8), 1369–1375.

    Article  PubMed  Google Scholar 

  • Santos, P. S. C., Schinemann, J. A., Gabardo, J., & da Graça Bicalho, M. (2005). New evidence that the MHC influences odor perception in humans: a study with 58 Southern Brazilian students. Hormones and Behavior, 47(4), 384–388.

    Article  PubMed  Google Scholar 

  • Saphire-Bernstein, S., Larson, C. M., Gildersleeve, K. A., Fales, M. R., Pillsworth, E. G., & Haselton, M. G. (2016). Genetic compatibility in long-term intimate relationships: partner similarity at major histocompatibility complex (MHC) genes may reduce in-pair attraction. Evolution and Human Behavior. doi:10.1016/j.evolhumbehav.2016.09.003.

    Google Scholar 

  • Thornhill, R., & Gangestad, S. W. (2008). The evolutionary biology of human female sexuality. Oxford: Oxford University Press.

    Google Scholar 

  • Thornhill, R., Gangestad, S. W., Miller, R., Scheyd, G., McCollough, J. K., & Franklin, M. (2003). Major histocompatibility complex genes, symmetry, and body scent attractiveness in men and women. Behavioral Ecology, 14(5), 668–678.

    Article  Google Scholar 

  • Wedekind, C., & Füri, S. (1997). Body odour preferences in men and women: do they aim for specific MHC combinations or simply heterozygosity? Proceedings of the Royal Society of London B: Biological Sciences, 264(1387), 1471–1479.

    Article  Google Scholar 

  • Wedekind, C., Seebeck, T., Bettens, F., & Paepke, A. J. (1995). MHC-dependent mate preferences in humans. Proceedings of the Royal Society of London B: Biological Sciences, 260(1359), 245–249.

    Article  Google Scholar 

  • World Health Organization. (2015). Antibiotic resistance. Retrieved from http://www.who.int/mediacentre/factsheets/antibiotic-resistance/en/

  • Yamazaki, K., Boyse, E., Mike, V., Thaler, H., Mathieson, B., Abbott, J.,…Thomas, L. (1976). Control of mating preferences in mice by genes in the major histocompatibility complex. The Journal of Experimental Medicine, 144(5), 1324-1335.

  • Yamazaki, K., Beauchamp, G. K., Kupniewski, D., Bard, J., Thomas, L., & Boyse, E. (1988). Familial imprinting determines H-2 selective mating preferences. Science, 240(4857), 1331–1332.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Baruch Ivcher School of Psychology, Interdisciplinary Center (IDC) Herzliya, P.O. Box 167, Herzliya, 46150, Israel

    Sheer Birnbaum, Gurit E. Birnbaum & Tsachi Ein-Dor

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  1. Sheer Birnbaum
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  2. Gurit E. Birnbaum
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  3. Tsachi Ein-Dor
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Correspondence to Tsachi Ein-Dor.

Appendix: Child Health Questionnaire

Appendix: Child Health Questionnaire

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Birnbaum, S., Birnbaum, G.E. & Ein-Dor, T. Can Contraceptive Pill Affect Future Offspring’s Health? The Implications of Using Hormonal Birth Control for Human Evolution. Evolutionary Psychological Science 3, 89–96 (2017). https://doi.org/10.1007/s40806-016-0074-4

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  • DOI: https://doi.org/10.1007/s40806-016-0074-4

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