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Sleep and Circadian Rhythm Disorders in Parkinson’s Disease

  • Sleep and Neurodegenerative Disorders (Y-E Ju, Section Editor)
  • Published:
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Abstract

Purpose of Review

Sleep disorders are among the most challenging non-motor features of Parkinson’s disease (PD) and significantly affect quality of life. Research in this field has gained recent interest among clinicians and scientists and is rapidly evolving. This review is dedicated to sleep and circadian dysfunction associated with PD.

Recent Findings

Most primary sleep disorders may co-exist with PD; the majority of these disorders have unique features when expressed in the PD population.

Summary

We discuss the specific considerations related to the common sleep problems in Parkinson’s disease including insomnia, rapid eye movement sleep behavior disorder, restless legs syndrome, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. Within each of these sleep disorders, we present updated definitions, epidemiology, etiology, diagnosis, clinical implications, and management. Furthermore, areas of potential interest for further research are outlined.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol aging. 2003;24(2):197–211.

    Article  PubMed  Google Scholar 

  2. Medicine AAoS. The International Classification of Sleep Disorders: Diagnostic and Coding Manual. American Academy of Sleep Medicine. 2014; 3rd ed. Rev. ed. Darien, IL.

  3. (WHO) WHO. International Classification of Diseases (ICD). 1994; 10th edition(WHO, Geneva, Switzerland).

  4. Association AP. Diagnostic and statistical manual of mental disorders. 2013; 5th edition(D.A.P.A, Washington).

  5. Ylikoski A, Martikainen K, Sieminski M, Partinen M. Parkinson’s disease and insomnia. Neurol Sci. 2015;36(11):2003–10.

    Article  PubMed  Google Scholar 

  6. Loddo G, Calandra-Buonaura G, Sambati L, Giannini G, Cecere A, Cortelli P, et al. The treatment of sleep disorders in Parkinson’s disease: from research to clinical practice. Front Neurol. 2017;8:42.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson’s disease. Mov Disord. 1998;13(6):895–9.

    Article  CAS  PubMed  Google Scholar 

  8. Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Med Rev. 2016. doi:10.1016/j.smrv.2016.08.001.

  9. Zhu K, van Hilten JJ, Marinus J. The course of insomnia in Parkinson’s disease. Parkinsonism Relat Disord. 2016;33:51–7.

    Article  PubMed  Google Scholar 

  10. Tholfsen LK, Larsen JP, Schulz J, Tysnes OB, Gjerstad MD. Changes in insomnia subtypes in early Parkinson disease. Neurology. 2017;88(4):352–8.

    Article  PubMed  Google Scholar 

  11. Dhawan V, Dhoat S, Williams AJ, Dimarco A, Pal S, Forbes A, et al. The range and nature of sleep dysfunction in untreated Parkinson’s disease (PD). A comparative controlled clinical study using the Parkinson’s disease sleep scale and selective polysomnography. J Neurol Sci. 2006;248(1–2):158–62.

    Article  CAS  PubMed  Google Scholar 

  12. Chahine LM, Daley J, Horn S, Duda JE, Colcher A, Hurtig H, et al. Association between dopaminergic medications and nocturnal sleep in early-stage Parkinson’s disease. Parkinsonism Relat Disord. 2013;19(10):859–63.

    Article  PubMed  Google Scholar 

  13. Monti JM, Hawkins M, Jantos H, D'Angelo L, Fernandez M. Biphasic effects of dopamine D-2 receptor agonists on sleep and wakefulness in the rat. Psychopharmacology. 1988;95(3):395–400.

    Article  CAS  PubMed  Google Scholar 

  14. Cianchetti C, Masala C, Mangoni A, Gessa GL. Suppression of REM and delta sleep by apomorphine in man: a dopamine mimetic effect. Psychopharmacology. 1980;67(1):61–5.

    Article  CAS  PubMed  Google Scholar 

  15. Diederich NJ, Vaillant M, Leischen M, Mancuso G, Golinval S, Nati R, et al. Sleep apnea syndrome in Parkinson’s disease. a case-control study in 49 patients. Mov Disord. 2005;20(11):1413–8.

    Article  PubMed  Google Scholar 

  16. Mollayeva T, Thurairajah P, Burton K, Mollayeva S, Shapiro CM, Colantonio A. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: a systematic review and meta-analysis. Sleep Med Rev. 2016;25:52–73.

    Article  PubMed  Google Scholar 

  17. Trenkwalder C, Kohnen R, Hogl B, Metta V, Sixel-Doring F, Frauscher B, et al. Parkinson’s disease sleep scale—validation of the revised version PDSS-2. Mov Disord. 2011;26(4):644–52.

    Article  PubMed  Google Scholar 

  18. Norlinah MI, Afidah KN, Noradina AT, Shamsul AS, Hamidon BB, Sahathevan R, et al. Sleep disturbances in Malaysian patients with Parkinson’s disease using polysomnography and PDSS. Parkinsonism Relat Disord. 2009;15(9):670–4.

    Article  CAS  PubMed  Google Scholar 

  19. Marinus J, Visser M, van Hilten JJ, Lammers GJ, Stiggelbout AM. Assessment of sleep and sleepiness in Parkinson disease. Sleep. 2003;26(8):1049–54.

    Article  PubMed  Google Scholar 

  20. Stavitsky K, Saurman JL, McNamara P, Cronin-Golomb A. Sleep in Parkinson’s disease: a comparison of actigraphy and subjective measures. Parkinsonism Relat Disord. 2010;16(4):280–3.

    Article  CAS  PubMed  Google Scholar 

  21. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, et al. MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord. 2015;30(12):1591–601.

    Article  PubMed  Google Scholar 

  22. Gomez-Esteban JC, Zarranz JJ, Lezcano E, Velasco F, Ciordia R, Rouco I, et al. Sleep complaints and their relation with drug treatment in patients suffering from Parkinson’s disease. Mov Disord. 2006;21(7):983–8.

    Article  PubMed  Google Scholar 

  23. Stocchi F, Barbato L, Nordera G, Berardelli A, Ruggieri S. Sleep disorders in Parkinson’s disease. J Neurol. 1998;245(Suppl 1):S15–8.

    Article  PubMed  Google Scholar 

  24. Chung S, Bohnen NI, Albin RL, Frey KA, Muller ML, Chervin RD. Insomnia and sleepiness in Parkinson disease: associations with symptoms and comorbidities. J Clin Sleep Med. 2013;9(11):1131–7.

    PubMed  PubMed Central  Google Scholar 

  25. Tijero B, Somme J, Gomez-Esteban JC, Berganzo K, Adhikari I, Lezcano E, et al. Relationship between sleep and dysautonomic symptoms assessed by self-report scales. Mov Disord. 2011;26(10):1967–8.

    Article  PubMed  Google Scholar 

  26. Erro R, Santangelo G, Picillo M, Vitale C, Amboni M, Longo K, et al. Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. J Neurol. 2012;259(9):1808–13.

    Article  PubMed  Google Scholar 

  27. Suzuki K, Miyamoto M, Miyamoto T, Okuma Y, Hattori N, Kamei S, et al. Correlation between depressive symptoms and nocturnal disturbances in Japanese patients with Parkinson’s disease. Parkinsonism Relat Disord. 2009;15(1):15–9.

    Article  PubMed  Google Scholar 

  28. Anang JB, Gagnon JF, Bertrand JA, Romenets SR, Latreille V, Panisset M, et al. Predictors of dementia in Parkinson disease: a prospective cohort study. Neurology. 2014;83(14):1253–60.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Forsaa EB, Larsen JP, Wentzel-Larsen T, Herlofson K, Alves G. Predictors and course of health-related quality of life in Parkinson’s disease. Mov Disord. 2008;23(10):1420–7.

    Article  PubMed  Google Scholar 

  30. Wailke S, Herzog J, Witt K, Deuschl G, Volkmann J. Effect of controlled-release levodopa on the microstructure of sleep in Parkinson’s disease. Eur J Neurol. 2011;18(4):590–6.

    Article  CAS  PubMed  Google Scholar 

  31. Ray Chaudhuri K, Martinez-Martin P, Rolfe KA, Cooper J, Rockett CB, Giorgi L, et al. Improvements in nocturnal symptoms with ropinirole prolonged release in patients with advanced Parkinson’s disease. Eur J Neurol. 2012;19(1):105–13.

    Article  CAS  PubMed  Google Scholar 

  32. Pierantozzi M, Placidi F, Liguori C, Albanese M, Imbriani P, Marciani MG, et al. Rotigotine may improve sleep architecture in Parkinson’s disease: a double-blind, randomized, placebo-controlled polysomnographic study. Sleep Med. 2016;21:140–4.

    Article  PubMed  Google Scholar 

  33. Rios Romenets S, Creti L, Fichten C, Bailes S, Libman E, Pelletier A, et al. Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson’s disease—a randomized study. Parkinsonism Relat Disord. 2013;19(7):670–5.

    Article  CAS  PubMed  Google Scholar 

  34. Yang H, Petrini M. Effect of cognitive behavior therapy on sleep disorder in Parkinson’s disease in China: a pilot study. Nurs Health Sci. 2012;14(4):458–63.

    Article  PubMed  Google Scholar 

  35. Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 2012;9(4):687–701.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Paus S, Brecht HM, Koster J, Seeger G, Klockgether T, Wullner U. Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease. Mov Disord. 2003;18(6):659–67.

    Article  PubMed  Google Scholar 

  37. Frucht S, Rogers JD, Greene PE, Gordon MF, Fahn S. Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology. 1999;52(9):1908–10.

    Article  CAS  PubMed  Google Scholar 

  38. Bjornara KA, Dietrichs E, Toft M. Clinical features associated with sleep disturbances in Parkinson’s disease. Clin Neurol Neurosurg. 2014;124:37–43.

    Article  PubMed  Google Scholar 

  39. Yong MH, Fook-Chong S, Pavanni R, Lim LL, Tan EK. Case control polysomnographic studies of sleep disorders in Parkinson’s disease. PLoS One. 2011;6(7):e22511.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Verbaan D, van Rooden SM, Visser M, Marinus J, van Hilten JJ. Nighttime sleep problems and daytime sleepiness in Parkinson’s disease. Mov Disord. 2008;23(1):35–41.

    Article  PubMed  Google Scholar 

  41. Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP. Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology. 2006;67(5):853–8.

    Article  CAS  PubMed  Google Scholar 

  42. Cochen De Cock V, Bayard S, Jaussent I, Charif M, Grini M, Langenier MC, et al. Daytime sleepiness in Parkinson’s disease: a reappraisal. PLoS One. 2014;9(9):e107278.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  43. Tavora DG, de Bruin VM, Lopes Gama R, Lopes EM, Jorge IF, de Bruin PF. The nature of excessive sleepiness and sudden sleep onset in Parkinsons disease. Sleep Sci. 2014;7(1):13–8.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Korner Y, Meindorfner C, Moller JC, Stiasny-Kolster K, Haja D, Cassel W, et al. Predictors of sudden onset of sleep in Parkinson’s disease. Mov Disord. 2004;19(11):1298–305.

    Article  PubMed  Google Scholar 

  45. Tan EK, Lum SY, Wong MC. Restless legs syndrome in Parkinson’s disease. J Neurol Sci. 2002;196(1–2):33–6.

    Article  CAS  PubMed  Google Scholar 

  46. Poryazova R, Benninger D, Waldvogel D, Bassetti CL. Excessive daytime sleepiness in Parkinson’s disease: characteristics and determinants. Eur Neurol. 2010;63(3):129–35.

    Article  CAS  PubMed  Google Scholar 

  47. Matsui H, Nishinaka K, Oda M, Hara N, Komatsu K, Kubori T, et al. Excessive daytime sleepiness in Parkinson disease: a SPECT study. Sleep. 2006;29(7):917–20.

    Article  PubMed  Google Scholar 

  48. Thannickal TC, Lai YY, Siegel JM. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain. 2007;130(Pt 6):1586–95.

    Article  PubMed  Google Scholar 

  49. Fronczek R, Overeem S, Lee SY, Hegeman IM, van Pelt J, van Duinen SG, et al. Hypocretin (orexin) loss in Parkinson’s disease. Brain. 2007;130(Pt 6):1577–85.

    Article  PubMed  Google Scholar 

  50. Verbaan D, van Rooden SM, van Hilten JJ, Rijsman RM. Prevalence and clinical profile of restless legs syndrome in Parkinson’s disease. Mov Disord. 2010;25(13):2142–7.

    Article  PubMed  Google Scholar 

  51. Bhalsing K, Suresh K, Muthane UB, Pal PK. Prevalence and profile of restless legs syndrome in Parkinson’s disease and other neurodegenerative disorders: a case-control study. Parkinsonism Relat Disord. 2013;19(4):426–30.

    Article  PubMed  Google Scholar 

  52. Neikrug AB, Liu L, Avanzino JA, Maglione JE, Natarajan L, Bradley L, et al. Continuous positive airway pressure improves sleep and daytime sleepiness in patients with Parkinson disease and sleep apnea. Sleep. 2014;37(1):177–85.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Rolinski M, Szewczyk-Krolikowski K, Tomlinson PR, Nithi K, Talbot K, Ben-Shlomo Y, et al. REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2014;85(5):560–6.

    Article  PubMed  Google Scholar 

  54. Poryazova R, Oberholzer M, Baumann CR, Bassetti CL. REM sleep behavior disorder in Parkinson’s disease: a questionnaire-based survey. J Clin Sleep Med. 2013;9(1):55–9a.

    PubMed  PubMed Central  Google Scholar 

  55. Arnulf I, Leu-Semenescu S. Sleepiness in Parkinson’s disease. Parkinsonism Relat Disord. 2009;15(Suppl 3):S101–4.

    Article  PubMed  Google Scholar 

  56. Videnovic A, Noble C, Reid KJ, Peng J, Turek FW, Marconi A, et al. Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol. 2014;71(4):463–9.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Chervin RD. Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. Chest. 2000;118(2):372–9.

    Article  CAS  PubMed  Google Scholar 

  58. Thorpy MJ. The clinical use of the multiple sleep latency test. The standards of practice Committee of the American Sleep Disorders Association. Sleep. 1992;15(3):268–76.

    Article  CAS  PubMed  Google Scholar 

  59. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14(6):540–5.

    Article  CAS  PubMed  Google Scholar 

  60. Cai SJ, Chen R, Zhang YL, Xiong KP, Lian YX, Li J, et al. Correlation of Epworth sleepiness scale with multiple sleep latency test and its diagnostic accuracy in assessing excessive daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome. Chin Med J. 2013;126(17):3245–50.

    PubMed  Google Scholar 

  61. Ataide M, Franco CM, Lins OG. Daytime sleepiness and Parkinson’s disease: the contribution of the multiple sleep latency test. Sleep Disord. 2014;2014:767181.

    PubMed  PubMed Central  Google Scholar 

  62. Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Reduced cognitive function in patients with Parkinson’s disease and obstructive sleep apnea. Neurology. (2017); Accepted for publication on January 3rd 2017.

  63. Gong Y, Liu CF. An analysis of clinical characteristics and factors in Parkinson’s disease patients with excessive daytime sleepiness. Zhonghua Nei Ke Za Zhi. 2016;55(7):515–9.

    CAS  PubMed  Google Scholar 

  64. Pandey S, Bajaj BK, Wadhwa A, Anand KS. Impact of sleep quality on the quality of life of patients with Parkinson’s disease: a questionnaire based study. Clin Neurol Neurosurg. 2016;148:29–34.

    Article  PubMed  Google Scholar 

  65. Qin Z, Zhang L, Sun F, Fang X, Meng C, Tanner C, et al. Health related quality of life in early Parkinson’s disease: impact of motor and non-motor symptoms, results from Chinese levodopa exposed cohort. Parkinsonism Relat Disord. 2009;15(10):767–71.

    Article  PubMed  Google Scholar 

  66. Goldman JG, Stebbins GT, Leung V, Tilley BC, Goetz CG. Relationships among cognitive impairment, sleep, and fatigue in Parkinson’s disease using the MDS-UPDRS. Parkinsonism Relat Disord. 2014;20(11):1135–9.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Perez Lloret S, Rossi M, Merello M, Rascol O, Cardinali DP. Nonmotor symptoms groups in Parkinson’s disease patients: results of a pilot, exploratory study. Parkinsons Dis. 2011;2011:473579.

    PubMed  PubMed Central  Google Scholar 

  68. Verbaan D, Marinus J, Visser M, van Rooden SM, Stiggelbout AM, van Hilten JJ. Patient-reported autonomic symptoms in Parkinson disease. Neurology. 2007;69(4):333–41.

    Article  CAS  PubMed  Google Scholar 

  69. Zhou J, Zhang J, Lam SP, Chan JW, Mok V, Chan A, et al. Excessive daytime sleepiness predicts neurodegeneration in idiopathic REM sleep behavior disorder. Sleep. (2017).

  70. Baumann CR, Scammell TE, Bassetti CL. Parkinson’s disease, sleepiness and hypocretin/orexin. Brain. 2008;131(Pt 3):e91.

    Article  PubMed  Google Scholar 

  71. van Maanen A, Meijer AM, van der Heijden KB, Oort FJ. The effects of light therapy on sleep problems: a systematic review and meta-analysis. Sleep Med Rev. 2016;29:52–62.

    Article  PubMed  Google Scholar 

  72. • Videnovic A, Klerman EB, Wang W, Marconi A, Kuhta T, Zee PC. Timed light therapy for sleep and daytime sleepiness associated with Parkinson disease: a randomized clinical trial. JAMA Neurol. (2017) This article is recent trial that assessed safety and efficacy of light therapy on excessive daytime sleepiness in Parkinson’s disease patients. It highlights non-invasive and effective way to manage impaired alertness and poor sleep in Parkinson’s disease.

  73. Ondo WG, Fayle R, Atassi F, Jankovic J. Modafinil for daytime somnolence in Parkinson’s disease: double blind, placebo controlled parallel trial. J Neurol Neurosurg Psychiatry. 2005;76(12):1636–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Adler CH, Caviness JN, Hentz JG, Lind M, Tiede J. Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson’s disease. Mov Disord. 2003;18(3):287–93.

    Article  PubMed  Google Scholar 

  75. Hogl B, Saletu M, Brandauer E, Glatzl S, Frauscher B, Seppi K, et al. Modafinil for the treatment of daytime sleepiness in Parkinson’s disease: a double-blind, randomized, crossover, placebo-controlled polygraphic trial. Sleep. 2002;25(8):905–9.

    Article  CAS  PubMed  Google Scholar 

  76. Ondo WG, Perkins T, Swick T, Hull KL Jr, Jimenez JE, Garris TS, et al. Sodium oxybate for excessive daytime sleepiness in Parkinson disease: an open-label polysomnographic study. Arch Neurol. 2008;65(10):1337–40.

    Article  PubMed  Google Scholar 

  77. Ramirez JM, Garcia AJ 3rd, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, et al. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013;189(2):344–53.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Neikrug AB, Maglione JE, Liu L, Natarajan L, Avanzino JA, Corey-Bloom J, et al. Effects of sleep disorders on the non-motor symptoms of Parkinson disease. J Clin Sleep Med. 2013;9(11):1119–29.

    PubMed  PubMed Central  Google Scholar 

  79. Valko PO, Hauser S, Sommerauer M, Werth E, Baumann CR. Observations on sleep-disordered breathing in idiopathic Parkinson’s disease. PLoS One. 2014;9(6):e100828.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Beland SG, Postuma RB, Latreille V, Bertrand JA, Panisset M, Chouinard S, et al. Observational study of the relation between Parkinson’s disease and sleep apnea. J Parkinsons Dis. 2015;5(4):805–11.

    Article  PubMed  Google Scholar 

  81. Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Diagnosis of obstructive sleep apnea in Parkinson’s disease patients: is unattended portable monitoring a suitable tool? Parkinsons Dis. 2015;2015:258418.

    PubMed  PubMed Central  Google Scholar 

  82. Trotti LM, Bliwise DL. No increased risk of obstructive sleep apnea in Parkinson’s disease. Mov Disord. 2010;25(13):2246–9.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M, et al. Is obstructive sleep apnea a problem in Parkinson’s disease? Sleep Med. 2010;11(3):247–52.

    Article  PubMed  Google Scholar 

  84. Yeh NC, Tien KJ, Yang CM, Wang JJ, Weng SF. Increased risk of Parkinson’s disease in patients with obstructive sleep apnea: a population-based, propensity score-matched, longitudinal follow-up study. Medicine (Baltimore). 2016;95(2):e2293.

    Article  Google Scholar 

  85. Chen JC, Tsai TY, Li CY, Hwang JH. Obstructive sleep apnea and risk of Parkinson’s disease: a population-based cohort study. J Sleep Res. 2015;24(4):432–7.

    Article  PubMed  Google Scholar 

  86. Sheu JJ, Lee HC, Lin HC, Kao LT, Chung SD. A 5-year follow-up study on the relationship between obstructive sleep apnea and Parkinson disease. J Clin Sleep Med. 2015;11(12):1403–8.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Hovestadt A, Bogaard JM, Meerwaldt JD, van der Meche FG, Stigt J. Pulmonary function in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1989;52(3):329–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Vincken WG, Gauthier SG, Dollfuss RE, Hanson RE, Darauay CM, Cosio MG. Involvement of upper-airway muscles in extrapyramidal disorders. a cause of airflow limitation. N Engl J Med. 1984;311(7):438–42.

    Article  CAS  PubMed  Google Scholar 

  89. Herer B, Arnulf I, Housset B. Effects of levodopa on pulmonary function in Parkinson’s disease. Chest. 2001;119(2):387–93.

    Article  CAS  PubMed  Google Scholar 

  90. Vincken WG, Darauay CM, Cosio MG. Reversibility of upper airway obstruction after levodopa therapy in Parkinson’s disease. Chest. 1989;96(1):210–2.

    Article  CAS  PubMed  Google Scholar 

  91. Tsai CC, Wu MN, Liou LM, Chang YP. Levodopa reverse stridor and prevent subsequent endotracheal intubation in Parkinson disease patients with bilateral vocal cord palsy: a case report. Medicine (Baltimore). 2016;95(50):e5559.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Iber C, Ancoli-Israel S, Chesson AL, Quran SF. The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specifications. 1st ed. Westchester: American Academy of Sleep Medicine; 2007.

    Google Scholar 

  93. Collop NA, Anderson WM, Boehlecke B, Claman D, Goldberg R, Gottlieb DJ, et al. Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Portable monitoring task force of the American academy of sleep medicine. J Clin Sleep Med. 2007;3(7):737–47.

    PubMed  Google Scholar 

  94. El Shayeb M, Topfer LA, Stafinski T, Pawluk L, Menon D. Diagnostic accuracy of level 3 portable sleep tests versus level 1 polysomnography for sleep-disordered breathing: a systematic review and meta-analysis. CMAJ. 2014;186(1):E25–51.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Boynton G, Vahabzadeh A, Hammoud S, Ruzicka DL, Chervin RD. Validation of the STOP-BANG Questionnaire among patients referred for suspected obstructive sleep apnea. J Sleep Disord Treat Care. (2013); 2(4).

  96. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP. Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med. 1999;131(7):485–91.

    Article  CAS  PubMed  Google Scholar 

  97. Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Validation of two questionnaires for obstructive sleep apnea screening in Parkinson’s disease patients [abstract]. Mov Disord. 2014;29(Suppl. 1):788.

    Google Scholar 

  98. Harmell AL, Neikrug AB, Palmer BW, Avanzino JA, Liu L, Maglione JE, et al. Obstructive sleep apnea and cognition in Parkinson’s disease. Sleep Med. 2016;21:28–34.

    Article  PubMed  PubMed Central  Google Scholar 

  99. • Mery VP, Gros P, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology. 2017;88(12):1120–8. This article suggests obstructive sleep apnea may be a reversible contributor to several non-motor symptoms in Parkinson’s disease (PD) including sleepiness and cognitive dysfunction. It highlights the clinical importance of OSA in PD and supports further CPAP trial as a potential interesting treatment for cognitive decline in this population.

    Article  PubMed  Google Scholar 

  100. Lal C, Strange C, Bachman D. Neurocognitive impairment in obstructive sleep apnea. Chest. 2012;141(6):1601–10.

    Article  PubMed  Google Scholar 

  101. Zhan G, Fenik P, Pratico D, Veasey SC. Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury. Am J Respir Crit Care Med. 2005;171(12):1414–20.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Li Y, Veasey SC. Neurobiology and neuropathophysiology of obstructive sleep apnea. NeuroMolecular Med. 2012;14(3):168–79.

    Article  CAS  PubMed  Google Scholar 

  103. Lim DC, Pack AI. Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier. Sleep Med Rev. 2014;18(1):35–48.

    Article  PubMed  Google Scholar 

  104. Hoth KF, Zimmerman ME, Meschede KA, Arnedt JT, Aloia MS. Obstructive sleep apnea: impact of hypoxemia on memory. Sleep Breath. 2013;17(2):811–7.

    Article  PubMed  Google Scholar 

  105. Kylstra WA, Aaronson JA, Hofman WF, Schmand BA. Neuropsychological functioning after CPAP treatment in obstructive sleep apnea: a meta-analysis. Sleep Med Rev. 2013;17(5):341–7.

    Article  PubMed  Google Scholar 

  106. Kushida CA, Nichols DA, Holmes TH, Quan SF, Walsh JK, Gottlieb DJ, et al. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the apnea positive pressure long-term efficacy study (APPLES). Sleep. 2012;35(12):1593–602.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, Kaminska M. Treatment of obstructive sleep apnea with continuous positive airway pressure improves non-motor symptoms in Parkinson’s disease patients [abstract]. J Parkinson’s Dis. 2013;3(Supplement 1):Article 109.

    Google Scholar 

  108. Gros P, Mery VP, Lafontaine AL, Robinson A, Benedetti A, Kimoff RJ, et al. Obstructive sleep apnea in Parkinson’s disease patients: effect of Sinemet CR taken at bedtime. Sleep Breath. 2016;20(1):205–12.

    Article  PubMed  Google Scholar 

  109. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101–19.

    Article  PubMed  Google Scholar 

  110. Walters AS. Toward a better definition of the restless legs syndrome. The international restless legs syndrome study group. Mov Disord. 1995;10(5):634–42.

    Article  CAS  PubMed  Google Scholar 

  111. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated international restless legs syndrome study group (IRLSSG) consensus criteria—history, rationale, description, and significance. Sleep Med. 2014;15(8):860–73.

    Article  PubMed  Google Scholar 

  112. Rijsman RM, Schoolderman LF, Rundervoort RS, Louter M. Restless legs syndrome in Parkinson’s disease. Parkinsonism Relat Disord. 2014;20(Suppl 1):S5–9.

    Article  PubMed  Google Scholar 

  113. Peralta CM, Frauscher B, Seppi K, Wolf E, Wenning GK, Hogl B, et al. Restless legs syndrome in Parkinson’s disease. Mov Disord. 2009;24(14):2076–80.

    Article  PubMed  Google Scholar 

  114. Moccia M, Erro R, Picillo M, Santangelo G, Spina E, Allocca R, et al. A four-year longitudinal study on restless legs syndrome in Parkinson disease. Sleep. 2016;39(2):405–12.

    Article  PubMed  PubMed Central  Google Scholar 

  115. Shin HY, Youn J, Yoon WT, Kim JS, Cho JW. Restless legs syndrome in Korean patients with drug-naive Parkinson’s disease: a nation-wide study. Parkinsonism Relat Disord. 2013;19(3):355–8.

    Article  PubMed  Google Scholar 

  116. Suzuki K, Miyamoto M, Miyamoto T, Tatsumoto M, Watanabe Y, Suzuki S, et al. Nocturnal disturbances and restlessness in Parkinson’s disease: using the Japanese version of the Parkinson’s disease sleep scale-2. J Neurol Sci. 2012;318(1–2):76–81.

    Article  PubMed  Google Scholar 

  117. Ondo WG, He Y, Rajasekaran S, Le WD. Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord. 2000;15(1):154–8.

    Article  CAS  PubMed  Google Scholar 

  118. Rios Romenets S, Dauvilliers Y. Cochen de Cock V, Carlander B, Bayard S, Galatas C, et al. restless legs syndrome outside the blood-brain barrier—exacerbation by domperidone in Parkinson's disease. Parkinsonism Relat Disord. 2013;19(1):92–4.

    Article  CAS  PubMed  Google Scholar 

  119. Kwon DY, Seo WK, Yoon HK, Park MH, Koh SB, Park KW. Transcranial brain sonography in Parkinson’s disease with restless legs syndrome. Mov Disord. 2010;25(10):1373–8.

    Article  PubMed  Google Scholar 

  120. Ryu JH, Lee MS, Baik JS. Sonographic abnormalities in idiopathic restless legs syndrome (RLS) and RLS in Parkinson’s disease. Parkinsonism Relat Disord. 2011;17(3):201–3.

    Article  PubMed  Google Scholar 

  121. Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Med. 2003;4(2):121–32.

    Article  PubMed  Google Scholar 

  122. Moller JC, Unger M, Stiasny-Kolster K, Oertel WH. Restless legs syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? J Neurol Sci. 2010;289(1–2):135–7.

    Article  PubMed  Google Scholar 

  123. De Cock VC, Bayard S, Yu H, Grini M, Carlander B, Postuma R, et al. Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson’s disease. Mov Disord. 2012;27(6):743–9.

    Article  PubMed  Google Scholar 

  124. Fereshtehnejad SM, Shafieesabet M, Shahidi GA, Delbari A, Lokk J. Restless legs syndrome in patients with Parkinson’s disease: a comparative study on prevalence, clinical characteristics, quality of life and nutritional status. Acta Neurol Scand. 2015;131(4):211–8.

    Article  PubMed  Google Scholar 

  125. Krishnan PR, Bhatia M, Behari M. Restless legs syndrome in Parkinson’s disease: a case-controlled study. Mov Disord. 2003;18(2):181–5.

    Article  PubMed  Google Scholar 

  126. Nomura T, Inoue Y, Miyake M, Yasui K, Nakashima K. Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson’s disease. Mov Disord. 2006;21(3):380–4.

    Article  PubMed  Google Scholar 

  127. Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology. 2011;77(22):1941–6.

    Article  CAS  PubMed  Google Scholar 

  128. Winkelman JW, Sethi KD, Kushida CA, Becker PM, Koester J, Cappola JJ, et al. Efficacy and safety of pramipexole in restless legs syndrome. Neurology. 2006;67(6):1034–9.

    Article  CAS  PubMed  Google Scholar 

  129. Ma JF, Wan Q, Hu XY, Sun SG, Wang WZ, Zhao ZX, et al. Efficacy and safety of pramipexole in chinese patients with restless legs syndrome: results from a multi-center, randomized, double-blind, placebo-controlled trial. Sleep Med. 2012;13(1):58–63.

    Article  PubMed  Google Scholar 

  130. Zhang J, Liu B, Zheng Y, Chu T, Yang Z. Pramipexole for Chinese people with primary restless legs syndrome: a 12-week multicenter, randomized, double-blind study. Sleep Med. 2015;16(1):181–5.

    Article  PubMed  Google Scholar 

  131. Stiasny-Kolster K, Kohnen R, Schollmayer E, Moller JC, Oertel WH. Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot study. Mov Disord. 2004;19(12):1432–8.

    Article  PubMed  Google Scholar 

  132. Oertel WH, Benes H, Garcia-Borreguero D, Hogl B, Poewe W, Montagna P, et al. Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic study. Sleep Med. 2010;11(9):848–56.

    Article  PubMed  Google Scholar 

  133. Walters AS, Ondo WG, Dreykluft T, Grunstein R, Lee D, Sethi K. Ropinirole is effective in the treatment of restless legs syndrome. TREAT RLS 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled study. Mov Disord. 2004;19(12):1414–23.

    Article  PubMed  Google Scholar 

  134. Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, et al. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med. 2014;370(7):621–31.

    Article  CAS  PubMed  Google Scholar 

  135. Kushida CA, Walters AS, Becker P, Thein SG, Perkins AT, Roth T, et al. A randomized, double-blind, placebo-controlled, crossover study of XP13512/GSK1838262 in the treatment of patients with primary restless legs syndrome. Sleep. 2009;32(2):159–68.

    Article  PubMed  PubMed Central  Google Scholar 

  136. Walters AS, Ondo WG, Kushida CA, Becker PM, Ellenbogen AL, Canafax DM, et al. Gabapentin enacarbil in restless legs syndrome: a phase 2b, 2-week, randomized, double-blind, placebo-controlled trial. Clin Neuropharmacol. 2009;32(6):311–20.

    Article  CAS  PubMed  Google Scholar 

  137. Kushida CA, Becker PM, Ellenbogen AL, Canafax DM, Barrett RW. Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS. Neurology. 2009;72(5):439–46.

    Article  CAS  PubMed  Google Scholar 

  138. Lee DO, Ziman RB, Perkins AT, Poceta JS, Walters AS, Barrett RW. A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. J Clin Sleep Med. 2011;7(3):282–92.

    PubMed  PubMed Central  Google Scholar 

  139. Garcia-Borreguero D, Patrick J, DuBrava S, Becker PM, Lankford A, Chen C, et al. pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome. Sleep. 2014;37(4):635–43.

    Article  PubMed  PubMed Central  Google Scholar 

  140. Garcia-Borreguero D, Allen RP, Benes H, Earley C, Happe S, Hogl B, et al. Augmentation as a treatment complication of restless legs syndrome: concept and management. Mov Disord. 2007;22(Suppl 18):S476–84.

    Article  PubMed  Google Scholar 

  141. Trenkwalder C, Zieglgansberger W, Ahmedzai SH, Hogl B. Pain, opioids, and sleep: implications for restless legs syndrome treatment. Sleep Med. 2017;31:78–85.

    Article  PubMed  Google Scholar 

  142. Trenkwalder C, Benes H, Grote L, Garcia-Borreguero D, Hogl B, Hopp M, et al. Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurol. 2013;12(12):1141–50.

    Article  CAS  PubMed  Google Scholar 

  143. Driver-Dunckley E, Evidente VG, Adler CH, Hillman R, Hernandez J, Fletcher G, et al. Restless legs syndrome in Parkinson’s disease patients may improve with subthalamic stimulation. Mov Disord. 2006;21(8):1287–9.

    Article  PubMed  Google Scholar 

  144. Chahine LM, Ahmed A, Sun Z. Effects of STN DBS for Parkinson’s disease on restless legs syndrome and other sleep-related measures. Parkinsonism Relat Disord. 2011;17(3):208–11.

    Article  CAS  PubMed  Google Scholar 

  145. Videnovic A, Lazar AS, Barker RA, Overeem S. 'The clocks that time us—circadian rhythms in neurodegenerative disorders. Nat Rev Neurol. 2014;10(12):683–93.

    Article  PubMed  PubMed Central  Google Scholar 

  146. Kudo T, Loh DH, Truong D, Wu Y, Colwell CS. Circadian dysfunction in a mouse model of Parkinson’s disease. Exp Neurol. 2011;232(1):66–75.

    Article  PubMed  Google Scholar 

  147. Golombek DA, Rosenstein RE. Physiology of circadian entrainment. Physiol Rev. 2010;90(3):1063–102.

    Article  CAS  PubMed  Google Scholar 

  148. Bolitho SJ, Naismith SL, Rajaratnam SM, Grunstein RR, Hodges JR, Terpening Z, et al. Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med. 2014;15(3):342–7.

    Article  CAS  PubMed  Google Scholar 

  149. Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, et al. Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol. 2014;71(5):589–95.

    Article  PubMed  PubMed Central  Google Scholar 

  150. Paus S, Schmitz-Hubsch T, Wullner U, Vogel A, Klockgether T, Abele M. Bright light therapy in Parkinson’s disease: a pilot study. Mov Disord. 2007;22(10):1495–8.

    Article  PubMed  Google Scholar 

  151. Willis GL, Turner EJ. Primary and secondary features of Parkinson’s disease improve with strategic exposure to bright light: a case series study. Chronobiol Int. 2007;24(3):521–37.

    Article  PubMed  Google Scholar 

  152. Schenck CH, Bundlie SR, Ettinger MG, Mahowald MW. Chronic behavioral disorders of human REM sleep: a new category of parasomnia. Sleep. 1986;9(2):293–308.

    Article  CAS  PubMed  Google Scholar 

  153. Scaglione C, Vignatelli L, Plazzi G, Marchese R, Negrotti A, Rizzo G, et al. REM sleep behaviour disorder in Parkinson’s disease: a questionnaire-based study. Neurol Sci. 2005;25(6):316–21.

    Article  CAS  PubMed  Google Scholar 

  154. Wu YH, Liao YC, Chen YH, Chang MH, Lin CH. Risk of premotor symptoms in patients with newly diagnosed PD: a nationwide, population-based, case-control study in Taiwan. PLoS One. 2015;10(6):e0130282.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  155. Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: the NMSQuest study. Mov Disord. 2006;21(7):916–23.

    Article  PubMed  Google Scholar 

  156. Sixel-Doring F, Trautmann E, Mollenhauer B, Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? Sleep. 2014;37(3):431–8.

    Article  PubMed  PubMed Central  Google Scholar 

  157. Kang SH, Yoon IY, Lee SD, Han JW, Kim TH, Kim KW. REM sleep behavior disorder in the Korean elderly population: prevalence and clinical characteristics. Sleep. 2013;36(8):1147–52.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744–8.

    Article  PubMed  Google Scholar 

  159. • Iranzo A, Tolosa E, Gelpi E, Molinuevo JL, Valldeoriola F, Serradell M, et al. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study. Lancet Neurol. 2013;12(5):443–53. This study by Iranzo et al. suggest that most patients with idiopathic REM behavior disorder will eventually develop a Lewy Body disorder, with a prevalence increasing with longer follow-up. Patients with no definite diagnosis at the end of the study showed short-term risk for developing PD or DLB, such as decreased striatal dopamine transporter binding on imaging. This supports the notion that iRBD patients are interesting candidates for prodromal phase of disease studies, neuroprotective or disease modifying drugs trials.

    Article  PubMed  Google Scholar 

  160. Iranzo A, Fernandez-Arcos A, Tolosa E, Serradell M, Molinuevo JL, Valldeoriola F, et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS One. 2014;9(2):e89741.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  161. Boeve BF, Silber MH, Ferman TJ, Lin SC, Benarroch EE, Schmeichel AM, et al. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder. Sleep Med. 2013;14(8):754–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  162. Postuma RB, Berg D. Advances in markers of prodromal Parkinson disease. Nat Rev Neurol. 2016;12(11):622–34.

    Article  CAS  PubMed  Google Scholar 

  163. Claassen DO, Josephs KA, Ahlskog JE, Silber MH, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010;75(6):494–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  164. Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, et al. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Ann Neurol. 2015;77(5):830–9.

    Article  PubMed  Google Scholar 

  165. Chahine LM, Xie SX, Simuni T, Tran B, Postuma R, Amara A, et al. Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder. Parkinsonism Relat Disord. 2016;27:102–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  166. Fantini ML, Farini E, Ortelli P, Zucconi M, Manconi M, Cappa S, et al. Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. Sleep. 2011;34(5):619–25.

    PubMed  PubMed Central  Google Scholar 

  167. Postuma RB, Bertrand JA, Montplaisir J, Desjardins C, Vendette M, Rios Romenets S, et al. Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson’s disease: a prospective study. Mov Disord. 2012;27(6):720–6.

    Article  PubMed  Google Scholar 

  168. Anang JB, Nomura T, Romenets SR, Nakashima K, Gagnon JF, Postuma RB. Dementia predictors in Parkinson disease: a validation study. J Parkinsons Dis. 2017;7(1):159–62.

    Article  PubMed  Google Scholar 

  169. Garcia-Lorenzo D, Longo-Dos Santos C, Ewenczyk C, Leu-Semenescu S, Gallea C, Quattrocchi G, et al. The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease. Brain. 2013;136(Pt 7):2120–9.

    Article  PubMed  PubMed Central  Google Scholar 

  170. Boeve BF, Silber MH, Saper CB, Ferman TJ, Dickson DW, Parisi JE, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007;130(Pt 11):2770–88.

    Article  CAS  PubMed  Google Scholar 

  171. Al-Qassabi A, Fereshtehnejad SM, Postuma RB. Sleep disturbances in the prodromal stage of Parkinson disease. Curr Treat Options Neurol. 2017;19(6):22.

    Article  PubMed  Google Scholar 

  172. Hogl B, Stefani A. REM sleep behavior disorder (RBD): update on diagnosis and treatment. Somnologie. 2017;21(Suppl 1):1–8.

    Article  PubMed  Google Scholar 

  173. Ferri R, Marelli S, Cosentino FI, Rundo F, Ferini-Strambi L, Zucconi M. Night-to-night variability of automatic quantitative parameters of the chin EMG amplitude (atonia index) in REM sleep behavior disorder. J Clin Sleep Med. 2013;9(3):253–8.

    PubMed  PubMed Central  Google Scholar 

  174. Zhang J, Lam SP, Ho CK, Li AM, Tsoh J, Mok V, et al. Diagnosis of REM sleep behavior disorder by video-polysomnographic study: is one night enough? Sleep. 2008;31(8):1179–85.

    PubMed  PubMed Central  Google Scholar 

  175. Stiasny-Kolster K, Mayer G, Schafer S, Moller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM sleep behavior disorder screening questionnaire—a new diagnostic instrument. Mov Disord. 2007;22(16):2386–93.

    Article  PubMed  Google Scholar 

  176. Li SX, Wing YK, Lam SP, Zhang J, Yu MW, Ho CK, et al. Validation of a new REM sleep behavior disorder questionnaire (RBDQ-HK). Sleep Med. 2010;11(1):43–8.

    Article  CAS  PubMed  Google Scholar 

  177. Frauscher B, Ehrmann L, Zamarian L, Auer F, Mitterling T, Gabelia D, et al. Validation of the Innsbruck REM sleep behavior disorder inventory. Mov Disord. 2012;27(13):1673–8.

    Article  PubMed  Google Scholar 

  178. Boeve BF, Molano JR, Ferman TJ, Lin SC, Bieniek K, Tippmann-Peikert M, et al. Validation of the Mayo sleep questionnaire to screen for REM sleep behavior disorder in a community-based sample. J Clin Sleep Med. 2013;9(5):475–80.

    PubMed  PubMed Central  Google Scholar 

  179. Boeve BF, Molano JR, Ferman TJ, Smith GE, Lin SC, Bieniek K, et al. Validation of the Mayo sleep questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep Med. 2011;12(5):445–53.

    Article  PubMed  PubMed Central  Google Scholar 

  180. Stiasny-Kolster K, Sixel-Doring F, Trenkwalder C, Heinzel-Gutenbrunner M, Seppi K, Poewe W, et al. Diagnostic value of the REM sleep behavior disorder screening questionnaire in Parkinson’s disease. Sleep Med. 2015;16(1):186–9.

    Article  PubMed  Google Scholar 

  181. Nomura T, Inoue Y, Kagimura T, Uemura Y, Nakashima K. Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients. Sleep Med. 2011;12(7):711–3.

    Article  PubMed  Google Scholar 

  182. Chahine LM, Daley J, Horn S, Colcher A, Hurtig H, Cantor C, et al. Questionnaire-based diagnosis of REM sleep behavior disorder in Parkinson’s disease. Mov Disord. 2013;28(8):1146–9.

    Article  PubMed  Google Scholar 

  183. Bolitho SJ, Naismith SL, Terpening Z, Grunstein RR, Melehan K, Yee BJ, et al. Investigating rapid eye movement sleep without atonia in Parkinson’s disease using the rapid eye movement sleep behavior disorder screening questionnaire. Mov Disord. 2014;29(6):736–42.

    Article  PubMed  Google Scholar 

  184. Berg D, Postuma RB, Adler CH, Bloem BR, Chan P, Dubois B, et al. MDS research criteria for prodromal Parkinson’s disease. Mov Disord. 2015;30(12):1600–11.

    Article  PubMed  Google Scholar 

  185. Gong Y, Xiong KP, Mao CJ, Shen Y, Hu WD, Huang JY, et al. Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Med. 2014;15(6):647–53.

    Article  PubMed  Google Scholar 

  186. Postuma RB, Gagnon JF, Vendette M, Charland K, Montplaisir J. Manifestations of Parkinson disease differ in association with REM sleep behavior disorder. Mov Disord. 2008;23(12):1665–72.

    Article  PubMed  Google Scholar 

  187. Vendette M, Gagnon JF, Decary A, Massicotte-Marquez J, Postuma RB, Doyon J, et al. REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology. 2007;69(19):1843–9.

    Article  CAS  PubMed  Google Scholar 

  188. Aurora RN, Zak RS, Maganti RK, Auerbach SH, Casey KR, Chowdhuri S, et al. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med. 2010;6(1):85–95.

    PubMed  PubMed Central  Google Scholar 

  189. Gagnon JF, Postuma RB, Montplaisir J. Update on the pharmacology of REM sleep behavior disorder. Neurology. 2006;67(5):742–7.

    Article  PubMed  Google Scholar 

  190. Kunz D, Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res. 2010;19(4):591–6.

    Article  PubMed  Google Scholar 

  191. McCarter SJ, Boswell CL, St Louis EK, Dueffert LG, Slocumb N, Boeve BF, et al. Treatment outcomes in REM sleep behavior disorder. Sleep Med. 2013;14(3):237–42.

    Article  PubMed  PubMed Central  Google Scholar 

  192. Fantini ML, Gagnon JF, Filipini D, Montplaisir J. The effects of pramipexole in REM sleep behavior disorder. Neurology. 2003;61(10):1418–20.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We would like to acknowledge the research support form NIH/MINDS. Grant numbers: R01NS099055 and K23NS07228.

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Priti Gros declares no conflict of interest.

Aleksandar Videnovic reports grants from NIH/NINDS during the conduct of the study.

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Gros, P., Videnovic, A. Sleep and Circadian Rhythm Disorders in Parkinson’s Disease. Curr Sleep Medicine Rep 3, 222–234 (2017). https://doi.org/10.1007/s40675-017-0079-y

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