Dear editor,
Faienza et al. measured serum irisin concentration in children and adult patients with Prader–Willi syndrome (PWS) [1]. By multiple regression analysis, serum irisin levels in pediatric and adult PWS could be predicted by the genetic background and 25(OH)-vitamin D levels. In addition, intelligent indicator was selected as a significant predictor of serum irisin in adult patients with PWS. I present information on the association between serum irisin, bone health and cognition.
By a randomized controlled trial with combination of exercise and vitamin D supplementation, inverse relationship between pro-inflammatory marker and serum irisin concentration became stronger [2]. According to a review by Zhong et al., regulation of bone cell metabolism by irisin might be accelerated by exercise and vitamin D [3].
Conti et al. measured serum irisin and brain-derived neurotrophic factor (BDNF) in patients with Alzheimer's disease (AD) [4]. Mean serum irisin concentration was significantly elevated in patients with agitation/aggression (AA), and it correlated with the duration of AA. In contrast, there was no significant change in serum BDNF. They considered that serum irisin concentration might reflect the clinical status of AD in relation to aberrant motor behavior.
Among several biological action of circulating irisin, I suppose that changes in bone metabolism and cognition may be related in older subjects, and comprehensive studies are needed to verify the inter-relationship among bone metabolism, cognition and serum irisin concentration.
References
Faienza MF, Brunetti G, Grugni G et al (2021) The genetic background and vitamin D supplementation can affect irisin levels in Prader–Willi syndrome. J Endocrinol Invest. https://doi.org/10.1007/s40618-021-01533-4(Epub2021Mar3)
Gmiat A, Mieszkowski J, Prusik K et al (2017) Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. Biogerontology 18(4):535–548
Zhong X, Sun X, Shan M et al (2021) The production, detection, and origin of irisin and its effect on bone cells. Int J Biol Macromol 178:316–324
Conti E, Grana D, Stefanoni G et al (2019) Irisin and BDNF serum levels and behavioral disturbances in Alzheimer’s disease. Neurol Sci 40(6):1145–1150
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This reply refers to the original article available at https://doi.org/10.1007/s40618-021-01533-4.
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Kawada, T. Letter to the editor Re: Faienza MF, Brunetti G, Grugni G, et al. The genetic background and vitamin D supplementation can affect irisin levels in Prader–Willi syndrome. J Endocrinol Invest 2021 Mar 3. https://doi.org/10.1007/s40618-021-01533-4. J Endocrinol Invest 45, 225 (2022). https://doi.org/10.1007/s40618-021-01640-2
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DOI: https://doi.org/10.1007/s40618-021-01640-2