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Changes in colorectal cancer incidence by site and age from 1973 to 2015: a SEER database analysis

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Abstract

Previous studies have reported incidence and mortality declines for colorectal cancer (CRC). We evaluated recent temporal trends of colorectal cancer in the United States for the last 4 decades. Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified primary CRCs diagnosed between 1973 and 2015. Temporal changes were evaluated by 6-year time periods. Age-adjusted incidence rates and annual percentage change (APC) for CRC were calculated by site and gender. Age-standardized relative survival rates were also evaluated. We identified 878,632 CRC patients, 51% of whom were men. For both genders, the proportions of new diagnoses of right-sided colon cancer (RCC) remained relatively stable, with the APC of − 0.8 and − 0.6 for the male and the female, respectively. There was a relative increase in RCC for the younger aged group (< 49 years). In contrast, the proportions of left-sided colon cancer (LCC) and rectosigmoid-cancer (RSC) decreased significantly over time. For those aged 0–49, the age adjusted incidence rates showed a small increase (in both genders), whereas age-adjusted incidence rates declined for those aged 50–64 and > 65 (in both genders). Our study showed near significance in the decline of CRC mortality rates in this population, except the 1-year age-standardized survival of LCC and RSC, and the 5-year age-standardized RCC in females. There was a significant increase in RCC for the younger aged group (< 49 years). In contrast, the proportions of LCC and RSC decreased significantly over time.

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Acknowledgements

We would like to thank the native English speaking scientists of Elixigen Company (Huntington Beach, California) for editing our manuscript.

Funding

This work was supported by the National Natural Science Foundation of China (Grants 81272641, 81572409, 81472578, 81773051).

Author information

Author notes

  1. Lin Yang, Shousheng Liu and Zhenchong Xiong contributed equally to this study.

Authors and Affiliations

  1. Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, No. 1023 South Shatai Road, Baiyun District, Guangzhou, 510515, People’s Republic of China

    Lin Yang & Qiankun Xie

  2. Department of General Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, No. 651 Dongfeng East Road, Guangzhou, 510060, People’s Republic of China

    Shousheng Liu, Zhenchong Xiong, Huijiao Cao, Wenzhuo He, Chang Jiang, Bei Zhang & Liangping Xia

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  1. Lin Yang
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  2. Shousheng Liu
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  3. Zhenchong Xiong
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  4. Huijiao Cao
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  5. Wenzhuo He
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  9. Liangping Xia
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Contributions

Conception and design: LY, BZ, and L-PX; methodology: LY, S-SL, Z-CX; collection and assembly of data: LY, S-SL, Z-CX, H-JC, W-ZH, Q-KX; data analysis and interpretation: LY, S-SL, CJ, Q-KX; manuscript writing: all authors; final approval of manuscript: all authors. All authors (LY, S-SL, Z-CX, H-JC, W-ZH, Q-KX, CJ, BZ, L-PX) have read and approved the final manuscript.

Corresponding authors

Correspondence to Bei Zhang or Liangping Xia.

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Conflict of interest

All authors have no conflicts of interest to declare.

Ethics approval and consent to participate

As the data used were from SEER dataset, which is publicly available, ethics approval and consent to participate is not applicable.

Statement of human and animal rights

The research involving humans was carried out according to the principles of the Declaration of Helsinki.

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Informed consent was not applicable in this retrospective study.

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Yang, L., Liu, S., Xiong, Z. et al. Changes in colorectal cancer incidence by site and age from 1973 to 2015: a SEER database analysis. Aging Clin Exp Res 33, 1937–1946 (2021). https://doi.org/10.1007/s40520-020-01721-x

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  • DOI: https://doi.org/10.1007/s40520-020-01721-x

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