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Safety and efficacy of ultrasound-guided percutaneous coaxial core biopsy of pancreatic lesions: a retrospective study

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Abstract

Background and objective

Pancreatic cancer tumors are difficult to access for biopsy. The use of coaxial needles during ultrasound (US)-guided coarse needle biopsy (CNB) may help to improve specimen collection yields and avoid tissue damage. In this retrospective study, the safety, efficacy, and clinical benefits of US-guided percutaneous coaxial CNB of pancreatic masses were evaluated and compared to those of non-coaxial CNB.

Methods

A total sample of 220 biopsies performed from August 2015 to August 2019 were analyzed, including 114 performed with a coaxial needle (17-gauge coaxial coarse needle combined with an 18-gauge coarse biopsy needle) and 106 performed with a non-coaxial needle (18-gauge coarse biopsy needle without a coaxial sheath). The coaxial CNB group was stratified by lesion location to further evaluate the applicability of coaxial core needles. The satisfactory specimen rate, diagnostic efficiency, operating time, and complication rate were compared statistically between groups and subgroups.

Results

Compared to the non-coaxial CNB group, the coaxial CNB group had a greater satisfactory specimen rate (98.3% vs. 92.3%; p = 0.048), a lesser mean operating time (8.9 ± 3.27 min vs. 16.8 ± 5.77 min; p < 0.001), and a lower complication rate (2.6% vs. 9.6%, p =0 .04). A better diagnostic efficiency was obtained for coaxial CNBs in the head of pancreas (98.7%) than in the body or tail of the pancreas (90%, p = 0.047).

Conclusion

For pancreatic masses, coaxial CNB can yield a higher satisfactory sample rate, lower complication rate, and shorter operating time than non-coaxial biopsy. US-guided percutaneous coaxial CNB is a safe and efficient puncture technique for pancreatic lesion diagnosis.

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Acknowledgements

We would like to thank all participants for their support in this study. No grant support needs to be reported.

Funding

This work did not receive funding.

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Author notes

  1. Yi Yang and Yujing Xin have contributed equally to this work.

Authors and Affiliations

  1. Department of Interventional Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Pan-jia-yuan South Lane, Chaoyang District, Beijing, 100021, China

    Yujing Xin, Yi Yang, Yi Chen, Yanan Wang & Xiang Zhou

  2. Department of Interventional Ultrasound, China-Japan Friendship Hospital, Beijing, 100021, China

    Xiao-Jing Cao

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  1. Yujing Xin
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  2. Yi Yang
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Correspondence to Xiang Zhou.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration, and its later amendments or comparable ethical standards.

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Xin, Y., Yang, Y., Chen, Y. et al. Safety and efficacy of ultrasound-guided percutaneous coaxial core biopsy of pancreatic lesions: a retrospective study. J Ultrasound 24, 269–277 (2021). https://doi.org/10.1007/s40477-020-00487-2

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  • DOI: https://doi.org/10.1007/s40477-020-00487-2

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