Abstract
Purpose
This report evaluates [68Ga]-Pentixafor and [18F]-FDG PET/CT uptake patterns of patients with lymphoproliferative malignancies.
Methods
Patients with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukaemia (CLL) who underwent [18F]-FDG PET/CT for staging followed by [68Ga]-Pentixafor PET/CT within 1 week were retrospectively evaluated. Patterns of [18F]-FDG and [68Ga]-Pentixafor uptake characteristics were described in histopathologically confirmed patients.
Results
Two patients with CLL, five with B-cell lymphomas, and four with T-cell lymphomas , with a mean age of 56.8 years (range 22–80), were included in this study. Four B-cell lymphoma patients were [18F]-FDG and [68Ga]-Pentixafor positive, whereas one patient was only [18F]-FDG-positive. [68Ga]-Pentixafor uptake in two patients and [18F]-FDG uptake in one patient was higher than the other, and one patient demonstrated a heterogeneous uptake pattern with flip-flop tracer uptake. Aggressive transformation to lymphoma in one CLL patient was presented with mild [68Ga]-Pentixafor uptake in the [18F]-FDG-positive lymph nodes. The other CLL patient had mild [18F]-FDG uptake and no [68Ga]-Pentixafor uptake in the lymph nodes, but bone marrow involvement was only detected by [68Ga]-Pentixafor PET/CT. Three of four patients with T-cell lymphoma patients demonstrated [18F]-FDG and [68Ga]-Pentixafor uptake, and one patient was only positive on [18F]-FDG PET/CT.
Conclusion
Our results demonstrate [68Ga]-Pentixafor uptake in different subtypes of NHL and CLL; however, the potential complementary role of [68Ga]-Pentixafor PET/CT towards personalized diagnostic concepts remains yet to be determined by further studies.
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SK: literature search, content planning, patient evaluation manuscript writing and editing; MYK: image acquisition, preparation of figures and literature review; EAA: writing of pathological findings and literature review, preparation of pathology figures; GY: writing of pathological findings and literature review, preparation of pathology figures; YS: patient evaluation manuscript writing and editing, literature review.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/ or national research committee and with the 1964 Helsinki Declaration and its later amendments.
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All patients gave written informed consent for [68Ga]-Pentixafor PET/CT imaging and publication of their medical data.
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Kuyumcu, S., Kıran, M.Y., Apaydın Arıkan, E. et al. [68Ga]-Pentixafor PET/CT imaging of lymphoproliferative malignancies. Clin Transl Imaging 9, 641–648 (2021). https://doi.org/10.1007/s40336-021-00458-5
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DOI: https://doi.org/10.1007/s40336-021-00458-5