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MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis

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Abstract

Background and Objective

MicroRNA (miR)-499 rs3746444 polymorphisms may participate in the pathogenesis of autoimmune diseases, but the results remain conflicting. We further investigated this association using a meta-analysis.

Methods

We conducted a retrieval of studies and obtained the eligible studies if they met inclusion criteria. Two researchers independently extracted the data from original articles. The genotype frequencies were analysed using Stata software.

Results

We finally archived six eligible studies that included 1,118 cases and 1,673 controls. After pooling the data, the results indicated that homozygote TT had an overall association with autoimmune diseases (TC + CC vs. TT: odds ratio [OR] 1.31, 95 % CI 1.11–1.55, p = 0.001). The allele C, genotype TC and CC, may be associated with rheumatoid arthritis (RA) risks in Mediterranean populations (C vs. T: OR 2. 00, 95 % CI 1.37–2.91, p < 0.001; TC vs. CC + TT: OR 1.76, 95 % CI 1.27–2.44; p = 0.001; CC vs. TC + TT: OR 2.31, 95 % CI 1.24–4.27, p = 0.008; CC vs. TT: OR 2.92, 95 % CI 1.59–5.37, p = 0.001; TC vs. TT: OR 1.98, 95 % CI 1.42–2.77). The genotype TT may decrease the risk of RA in Mediterranean populations (TC + CC vs. TT: OR 2.15, 95 % CI 1.57–2.94, p < 0.001) rather than in East Asians.

Conclusions

This study suggested that miR-499 polymorphisms were associated with a significantly increased risk of RA in Mediterranean populations.

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Acknowledgments

Supported by Yunnan Provincial Natural Science Foundation Grant of China (No.2013FB044). The authors are particularly grateful to the editors and reviewers for their help. The authors explicitly state that they have no conflicts of interest that are directly relevant to the content of this article.

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Authors and Affiliations

  1. Department of Physiology, School of Basic Medical Sciences, Kunming Medical University, Kunming, Yunnan, China

    Lechun Lu

  2. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

    Ying Tu, Jue Qi & Li He

  3. Department of Rehabilitation Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, China

    Lingxin Liu

  4. 295 Xichang Road, Kunming, 650500, Yunnan, People’s Republic of China

    Li He

Authors
  1. Lechun Lu
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  2. Ying Tu
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  3. Lingxin Liu
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  4. Jue Qi
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  5. Li He
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Corresponding author

Correspondence to Li He.

Additional information

Lechun Lu, Ying Tu and Lingxin Liu contributed equally to this manuscript.

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Lu, L., Tu, Y., Liu, L. et al. MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis. Mol Diagn Ther 18, 237–242 (2014). https://doi.org/10.1007/s40291-013-0073-0

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  • DOI: https://doi.org/10.1007/s40291-013-0073-0

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