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Managing Pediatric Pain in the Emergency Department

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Abstract

Far more attention is now given to pain management in children in the emergency department (ED). When a child arrives, pain must be recognized and evaluated using a pain scale that is appropriate to the child’s development and regularly assessed to determine whether the pain intervention was effective. At triage, both analgesics and non-pharmacological strategies, such as distraction, immobilization, and dressing should be started. For mild pain, oral ibuprofen can be administered if the child has not received it at home, whereas ibuprofen and paracetamol are suitable for moderate pain. For patients who still require pain relief, oral opioids could be considered; however, many EDs have now replaced this with intranasal fentanyl, which allows faster onset of pain relief and can be administered on arrival pending either intravenous access or definitive care. Intravenous opioids are often required for severe pain, and paracetamol or ibuprofen can still be considered for their likely opioid-sparing effects. Specific treatment should be used for patients with migraine. In children requiring intravenous access or venipuncture, non-pharmacological and pharmacological strategies to decrease pain and anxiety associated with needle punctures are mandatory. These strategies can also be used for laceration repairs and other painful procedures. Despite the gaps in knowledge, pain should be treated with the most up-to-date evidence in children seen in EDs.

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References

  1. Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7(6):620–3.

    Article  CAS  PubMed  Google Scholar 

  2. Ali S, Chambers A, Johnson DW, Newton AS, Vandermeer B, Williamson J, et al. Reported practice variation in pediatric pain management: a survey of Canadian pediatric emergency physicians. CJEM. 2014;16(5):352–60.

    PubMed  Google Scholar 

  3. Trottier ED, Ali S, Le May S, Gravel J. Treating and reducing anxiety and pain in the paediatric emergency department: the TRAPPED survey. Paediatr Child Health. 2015;20(5):239–44.

    PubMed  PubMed Central  Google Scholar 

  4. Johnston DCC, Gagnon PAJ, Fullerton ML, Common MC, Ladores BM, Forlini S. One-week survey of pain intensity on admission to and discharge from the emergency department: a pilot study 1. J Emerg Med. 1998;16(3):377–82. doi:10.1016/S0736-4679(98)00012-2.

    Article  CAS  PubMed  Google Scholar 

  5. Bailey B. Acute pain. In: Jovaisas B, editor. Compendium of therapeutic choices. 7th ed. Ottawa: Canadian Pharmacists Association; 2014. p. 189–99.

    Google Scholar 

  6. Krauss BS, Calligaris L, Green SM, Barbi E. Current concepts in management of pain in children in the emergency department. Lancet. 2016;387(10013):83–92. doi:10.1016/S0140-6736(14)61686-X.

    Article  PubMed  Google Scholar 

  7. Drendel AL, Kelly BT, Ali S. Pain assessment for children: overcoming challenges and optimizing care. Pediatr Emerg Care. 2011;27(8):773–81. doi:10.1097/PEC.0b013e31822877f7.

    Article  PubMed  Google Scholar 

  8. Puntillo K, Neighbor M, O’Neil N, Nixon R. Accuracy of emergency nurses in assessment of patients’ pain. Pain Manag Nurs. 2003;4(4):171–5.

    Article  PubMed  Google Scholar 

  9. Maciocia PM, Strachan EM, Akram AR, Hendrie RE, Kelly DN, Kemp A, et al. Pain assessment in the paediatric emergency department: whose view counts? Eur J Emerg Med. 2003;10(4):264–7. doi:10.1097/01.mej.0000103464.32882.e9.

    Article  PubMed  Google Scholar 

  10. St-Laurent-Gagnon T, Bernard-Bonnin AC, Villeneuve E. Pain evaluation in preschool children and by their parents. Acta Paediatr. 1999;88(4):422–7.

    Article  CAS  PubMed  Google Scholar 

  11. Shavit I, Kofman M, Leder M, Hod T, Kozer E. Observational pain assessment versus self-report in paediatric triage. Emerg Med J. 2008;25(9):552–5. doi:10.1136/emj.2008.058297.

    Article  CAS  PubMed  Google Scholar 

  12. Anonymous. Pain assessment and treatment in the managed care environment. A position statement from the American Pain Society. Case Manager. 2000;11(5):50–3.

  13. Bailey B, Daoust R, Doyon-Trottier E, Dauphin-Pierre S, Gravel J. Validation and properties of the verbal numeric scale in children with acute pain. Pain. 2010;149(2):216–21. doi:10.1016/j.pain.2009.12.008.

    Article  PubMed  Google Scholar 

  14. Bailey B, Bergeron S, Gravel J, Daoust R. Comparison of four pain scales in children with acute abdominal pain in a pediatric emergency department. Ann Emerg Med. 2007;50(4):379–83, 83 e1–2. doi:10.1016/j.annemergmed.2007.04.021.

  15. Huguet A, Stinson JN, McGrath PJ. Measurement of self-reported pain intensity in children and adolescents. J Psychosom Res. 2010;68(4):329–36. doi:10.1016/j.jpsychores.2009.06.003.

    Article  PubMed  Google Scholar 

  16. Stinson JN, Kavanagh T, Yamada J, Gill N, Stevens B. Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. Pain. 2006;125(1–2):143–57. doi:10.1016/j.pain.2006.05.006.

    Article  PubMed  Google Scholar 

  17. von Baeyer CL, Spagrud LJ. Systematic review of observational (behavioral) measures of pain for children and adolescents aged 3 to 18 years. Pain. 2007;127(1–2):140–50. doi:10.1016/j.pain.2006.08.014.

    Article  Google Scholar 

  18. Tomlinson D, von Baeyer CL, Stinson JN, Sung L. A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics. 2010;126(5):e1168–98. doi:10.1542/peds.2010-1609.

    Article  PubMed  Google Scholar 

  19. Srouji R, Ratnapalan S, Schneeweiss S. Pain in children: assessment and nonpharmacological management. Int J Pediatr. 2010;2010:11. doi:10.1155/2010/474838.

    Article  Google Scholar 

  20. Fournier-Charriere E, Tourniaire B, Carbajal R, Cimerman P, Lassauge F, Ricard C, et al. EVENDOL, a new behavioral pain scale for children ages 0 to 7 years in the emergency department: design and validation. Pain. 2012;153(8):1573–82. doi:10.1016/j.pain.2012.02.024.

    Article  PubMed  Google Scholar 

  21. Jain AA, Yeluri R, Munshi AK. Measurement and assessment of pain in children–a review. J Clin Pediatr Dent. 2012;37(2):125–36.

    Article  PubMed  Google Scholar 

  22. Voepel-Lewis T. Pain assessment and decision making: have we missed the mark? Pediatr Pain Lett. 2011;13(1):1–6.

    Google Scholar 

  23. Oakley E, Barnett P, Babl FE. Backslab versus nonbackslab for immobilization of undisplaced supracondylar fractures: a randomized trial. Pediatr Emerg Care. 2009;25(7):452–6. doi:10.1097/PEC.0b013e3181ab7898.

    Article  PubMed  Google Scholar 

  24. Mills E, Craig S, Oakley E. Busted! Management of paediatric upper limb fractures: not all that it’s cracked up to be. Emerg Med Australas. 2014;26(4):384–91. doi:10.1111/1742-6723.12265.

    Article  PubMed  Google Scholar 

  25. Tanabe P, Ferket K, Thomas R, Paice J, Marcantonio R. The effect of standard care, ibuprofen, and distraction on pain relief and patient satisfaction in children with musculoskeletal trauma. J Emerg Nurs. 2002;28(2):118–25.

    Article  PubMed  Google Scholar 

  26. Thomas D, Kircher J, Plint AC, Fitzpatrick E, Newton AS, Rosychuk RJ, et al. Pediatric pain management in the emergency department: the triage nurses’ perspective. J Emerg Nurs. 2015;41(5):407–13. doi:10.1016/j.jen.2015.02.012.

    Article  PubMed  Google Scholar 

  27. Fein JA, Zempsky WT, Cravero JP. Relief of pain and anxiety in pediatric patients in emergency medical systems. Pediatrics. 2012;130(5):e1391–405. doi:10.1542/peds.2012-2536.

    Article  PubMed  Google Scholar 

  28. Wright JA. An update of systemic analgesics in children. Anaesth Intensive Care Med. doi:10.1016/j.mpaic.2016.03.001. Epub 21 April 2016.

  29. Anonymous. Drugs for pain. Treat Guidel Med Lett. 2013;11(128):31–42 (quiz 2 p following).

  30. Pierce CA, Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review. Ann Pharmacother. 2010;44(3):489–506. doi:10.1345/aph.1M332.

    Article  CAS  PubMed  Google Scholar 

  31. Autret E, Reboul-Marty J, Henry-Launois B, Laborde C, Courcier S, Goehrs JM, et al. Evaluation of ibuprofen versus aspirin and paracetamol on efficacy and comfort in children with fever. Eur J Clin Pharmacol. 1997;51(5):367–71.

    Article  CAS  PubMed  Google Scholar 

  32. Clark E, Plint AC, Correll R, Gaboury I, Passi B. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics. 2007;119(3):460–7. doi:10.1542/peds.2006-1347.

    Article  PubMed  Google Scholar 

  33. Gazal G, Mackie IC. A comparison of paracetamol, ibuprofen or their combination for pain relief following extractions in children under general anaesthesia: a randomized controlled trial. Int J Paediatr Dent. 2007;17(3):169–77. doi:10.1111/j.1365-263X.2006.00806.x.

    Article  PubMed  Google Scholar 

  34. McGaw T, Raborn W, Grace M. Analgesics in pediatric dental surgery: relative efficacy of aluminum ibuprofen suspension and acetaminophen elixir. ASDC J Dent Child. 1987;54(2):106–9.

    CAS  PubMed  Google Scholar 

  35. Moore PA, Acs G, Hargreaves JA. Postextraction pain relief in children: a clinical trial of liquid analgesics. Int J Clin Pharmacol Ther Toxicol. 1985;23(11):573–7.

    CAS  PubMed  Google Scholar 

  36. Hamalainen ML, Hoppu K, Valkeila E, Santavuori P. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. Neurology. 1997;48(1):103–7.

    Article  CAS  PubMed  Google Scholar 

  37. Bertin L, Pons G, d’Athis P, Lasfargues G, Maudelonde C, Duhamel JF, et al. Randomized, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children. J Pediatr. 1991;119(5):811–4.

    Article  CAS  PubMed  Google Scholar 

  38. Schachtel BP, Thoden WR. A placebo-controlled model for assaying systemic analgesics in children. Clin Pharmacol Ther. 1993;53(5):593–601.

    Article  CAS  PubMed  Google Scholar 

  39. Hay AD, Costelloe C, Redmond NM, Montgomery AA, Fletcher M, Hollinghurst S, et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ. 2008;337. doi:10.1136/bmj.a1302.

  40. Smith C, Goldman RD. Alternating acetaminophen and ibuprofen for pain in children. Can Fam Physician. 2012;58(6):645–7.

    PubMed  PubMed Central  Google Scholar 

  41. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110(4):1170–9. doi:10.1213/ANE.0b013e3181cf9281.

    CAS  PubMed  Google Scholar 

  42. Pickering AE, Bridge HS, Nolan J, Stoddart PA. Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children. Br J Anaesth. 2002;88(1):72–7.

    Article  CAS  PubMed  Google Scholar 

  43. MacDonald N, MacLeod SM. Has the time come to phase out codeine? Can Med Assoc J. 2010;. doi:10.1503/cmaj.101411.

    Google Scholar 

  44. Dean L. Codeine therapy and CYP2D6 genotype. Medical genetics summaries. Bethesda: National Center for Biotechnology Information; 2012.

    Google Scholar 

  45. Niesters M, Overdyk F, Smith T, Aarts L, Dahan A. Opioid-induced respiratory depression in paediatrics: a review of case reports. Br J Anaesth. 2013;110(2):175–82. doi:10.1093/bja/aes447.

    Article  CAS  PubMed  Google Scholar 

  46. Wong C, Lau E, Palozzi L, Campbell F. Pain management in children: part 2—a transition from codeine to morphine for moderate to severe pain in children. Can Pharm J (Ott). 2012;145(6):276–9.e1. doi:10.3821/145.6.cpj276.

  47. Wille C, Bocquet N, Cojocaru B, Leis A, Cheron G. Oral morphine administration for children’s traumatic pain. Arch Pediatr. 2005;12(3):248–53. doi:10.1016/j.arcped.2004.07.021.

    Article  CAS  PubMed  Google Scholar 

  48. Wille-Ledon C, Chappuy H, Giraud C, Treluyer JM, Cheron G. Comparison of a morphine and midazolam combination with morphine alone for paediatric displaced fractures: a randomized study. Acta Paediatr. 2011;100(11):e203–7. doi:10.1111/j.1651-2227.2011.02311.x.

    Article  CAS  PubMed  Google Scholar 

  49. Poonai N, Bhullar G, Lin K, Papini A, Mainprize D, Howard J, et al. Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial. CMAJ. 2014;186(18):1358–63. doi:10.1503/cmaj.140907.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Murphy A, O’Sullivan R, Wakai A, Grant TS, Barrett MJ, Cronin J, et al. Intranasal fentanyl for the management of acute pain in children. Cochrane Database Syst Rev. 2014;10:CD009942. doi:10.1002/14651858.CD009942.pub2.

    PubMed  Google Scholar 

  51. Del Pizzo J, Callahan JM. Intranasal medications in pediatric emergency medicine. Pediatr Emerg Care. 2014;30(7):496–501. doi:10.1097/pec.0000000000000171 (quiz 2–4).

    Article  PubMed  Google Scholar 

  52. Schacherer NM, Erikson Ramirez D, Frazier SB, Perkins AM. Expedited delivery of pain medication for long-bone fractures using an intranasal fentanyl clinical pathway. Pediatr Emerg Care. 2015;31(8):560–3. doi:10.1097/pec.0000000000000435.

    Article  PubMed  Google Scholar 

  53. Mudd S. Intranasal fentanyl for pain management in children: a systematic review of the literature. J Pediatr Health Care. 2011;25(5):316–22. doi:10.1016/j.pedhc.2010.04.011.

    Article  PubMed  Google Scholar 

  54. Wolfe TR, Braude DA. Intranasal medication delivery for children: a brief review and update. Pediatrics. 2010;126(3):532–7. doi:10.1542/peds.2010-0616.

    Article  PubMed  Google Scholar 

  55. Wilson JA, Kendall JM, Cornelius P. Intranasal diamorphine for paediatric analgesia: assessment of safety and efficacy. J Accid Emerg Med. 1997;14(2):70–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Kendall JM, Reeves BC, Latter VS. Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. BMJ. 2001;322(7281):261–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Kidd S, Brennan S, Stephen R, Minns R, Beattie T. Comparison of morphine concentration-time profiles following intravenous and intranasal diamorphine in children. Arch Dis Child. 2009;94(12):974–8. doi:10.1136/adc.2008.140194.

    Article  CAS  PubMed  Google Scholar 

  58. Graudins A, Meek R, Egerton-Warburton D, Oakley E, Seith R. The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: a randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries. Ann Emerg Med. 2015;65(3):248–54 e1. doi:10.1016/j.annemergmed.2014.09.024.

  59. Yeaman F, Oakley E, Meek R, Graudins A. Sub-dissociative dose intranasal ketamine for limb injury pain in children in the emergency department: a pilot study. Emerg Med Australas. 2013;25(2):161–7. doi:10.1111/1742-6723.12059.

    Article  PubMed  Google Scholar 

  60. Kavanagh PL, Sprinz PG, Wolfgang TL, Killius K, Champigny M, Sobota A, et al. Improving the management of vaso-occlusive episodes in the pediatric emergency department. Pediatrics. 2015;136(4):e1016–25. doi:10.1542/peds.2014-3470.

    Article  PubMed  Google Scholar 

  61. Borland ML, Clark LJ, Esson A. Comparative review of the clinical use of intranasal fentanyl versus morphine in a paediatric emergency department. Emerg Med Australas. 2008;20(6):515–20. doi:10.1111/j.1742-6723.2008.01138.x.

    Article  PubMed  Google Scholar 

  62. Duedahl TH, Hansen EH. A qualitative systematic review of morphine treatment in children with postoperative pain. Pediatr Anesth. 2007;17(8):756–74. doi:10.1111/j.1460-9592.2007.02213.x.

    Article  Google Scholar 

  63. Motov S, Rockoff B, Cohen V, Pushkar I, Likourezos A, McKay C, et al. Intravenous subdissociative-dose ketamine versus morphine for analgesia in the emergency department: a randomized controlled trial. Ann Emerg Med. 2015;66(3):222–9 e1. doi:10.1016/j.annemergmed.2015.03.004.

  64. Wong I, St John-Green C, Walker SM. Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Paediatr Anaesth. 2013;23(6):475–95. doi:10.1111/pan.12163.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Patniyot IR, Gelfand AA. Acute treatment therapies for pediatric migraine: a qualitative systematic review. Headache. 2016;56(1):49–70. doi:10.1111/head.12746.

    Article  PubMed  Google Scholar 

  66. Bailey B, McManus BC. Treatment of children with migraine in the emergency department: a qualitative systematic review. Pediatr Emerg Care. 2008;24(5):321–30. doi:10.1097/PEC.0b013e31816ed047.

    Article  PubMed  Google Scholar 

  67. Brousseau DC, Duffy SJ, Anderson AC, Linakis JG. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med. 2004;43(2):256–62. doi:10.1016/s0196064403007169.

    Article  PubMed  Google Scholar 

  68. Hamalainen ML, Hoppu K, Santavuori PR. Oral dihydroergotamine for therapy-resistant migraine attacks in children. Pediatr Neurol. 1997;16(2):114–7.

    Article  CAS  PubMed  Google Scholar 

  69. Kabbouche M. Management of pediatric migraine headache in the emergency room and infusion center. Headache. 2015;55(10):1365–70. doi:10.1111/head.12694.

    Article  PubMed  Google Scholar 

  70. Coppola M, Yealy DM, Leibold RA. Randomized, placebo-controlled evaluation of prochlorperazine versus metoclopramide for emergency department treatment of migraine headache. Ann Emerg Med. 1995;26(5):541–6.

    Article  CAS  PubMed  Google Scholar 

  71. Kanis JM, Timm NL. Chlorpromazine for the treatment of migraine in a pediatric emergency department. Headache. 2014;54(2):335–42. doi:10.1111/head.12255.

    Article  PubMed  Google Scholar 

  72. Sin B, Wai M, Tatunchak T, Motov SM. The use of intravenous acetaminophen for acute pain in the emergency department. Acad Emerg Med. 2016. doi:10.1111/acem.12921.

  73. Shams Vahdati S, Morteza Baghi HR, Ghobadi J, Rajaei Ghafouri R, Habibollahi P. Comparison of paracetamol (Apotel®) and morphine in reducing post pure head trauma headache. Anesth Pain Med. 2014;4(3):e14903. doi:10.5812/aapm.14903.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Masoumi K, Forouzan A, Asgari Darian A, Feli M, Barzegari H, Khavanin A. Comparison of clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic: a randomized, double-blind. Controll Trial. Emerg Med Int. 2014;2014:5. doi:10.1155/2014/571326.

    Google Scholar 

  75. Tzortzopoulou A, McNicol ED, Cepeda MS, Francia MB, Farhat T, Schumann R. Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain. Cochrane Database Syst Rev. 2011;10:CD007126. doi:10.1002/14651858.CD007126.pub2.

    PubMed  Google Scholar 

  76. Hardwick WE Jr, Givens TG, Monroe KW, King WD, Lawley D. Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. Pediatr Emerg Care. 1999;15(3):179–82.

    Article  PubMed  Google Scholar 

  77. Pierce MC, Fuchs S. Evaluation of ketorolac in children with forearm fractures. Acad Emerg Med. 1997;4(1):22–6.

    Article  CAS  PubMed  Google Scholar 

  78. Neri E, Maestro A, Minen F, Montico M, Ronfani L, Zanon D, et al. Sublingual ketorolac versus sublingual tramadol for moderate to severe post-traumatic bone pain in children: a double-blind, randomised, controlled trial. Arch Dis Child. 2013;98(9):721–4. doi:10.1136/archdischild-2012-303527.

    Article  PubMed  Google Scholar 

  79. Inoue M, Caldarone CA, Frndova H, Cox PN, Ito S, Taddio A, et al. Safety and efficacy of ketorolac in children after cardiac surgery. Intensive Care Med. 2009;35(9):1584–92. doi:10.1007/s00134-009-1541-1.

    Article  CAS  PubMed  Google Scholar 

  80. Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43(13):879–923.

    Article  CAS  PubMed  Google Scholar 

  81. Schnabel A, Reichl SU, Meyer-Friessem C, Zahn PK, Pogatzki-Zahn E. Tramadol for postoperative pain treatment in children. Cochrane Database Sys Rev. 2015;3:CD009574. doi:10.1002/14651858.CD009574.pub2.

    Google Scholar 

  82. Orliaguet G, Hamza J, Couloigner V, Denoyelle F, Loriot MA, Broly F, et al. A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol. Pediatrics. 2015;135(3):e753–5. doi:10.1542/peds.2014-2673.

    Article  PubMed  Google Scholar 

  83. Friedrichsdorf SJ, Postier A, Eull D, Weidner C, Foster L, Gilbert M, et al. Pain outcomes in a US children’s hospital: a prospective cross-sectional survey. Hosp Pediatr. 2015;5(1):18–26. doi:10.1542/hpeds.2014-0084.

    Article  PubMed  Google Scholar 

  84. Uman LS, Birnie KA, Noel M, Parker JA, Chambers CT, McGrath PJ, et al. Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Sys Rev. 2013;10:CD005179. doi:10.1002/14651858.CD005179.pub3.

    Google Scholar 

  85. Pillai Riddell RR, Racine NM, Turcotte K, Uman LS, Horton RE, Din Osmun L, et al. Non-pharmacological management of infant and young child procedural pain. Cochrane Database Syst Rev. 2011;10:CD006275. doi:10.1002/14651858.CD006275.pub2.

    PubMed  Google Scholar 

  86. Shah V, Taddio A, McMurtry CM, Halperin SA, Noel M, Pillai Riddell R, et al. Pharmacological and combined interventions to reduce vaccine injection pain in children and adults: systematic review and meta-analysis. Clin J Pain. 2015;31(10 Suppl):S38–63. doi:10.1097/ajp.0000000000000281.

    Article  PubMed  Google Scholar 

  87. Shah PS, Herbozo C, Aliwalas LL, Shah VS. Breastfeeding or breast milk for procedural pain in neonates. Cochrane Database Syst Rev. 2012;12:CD004950. doi:10.1002/14651858.CD004950.pub3.

    PubMed  Google Scholar 

  88. Sparks LA, Setlik J, Luhman J. Parental holding and positioning to decrease IV distress in young children: a randomized controlled trial. J Pediatr Nurs. 2007;22(6):440–7. doi:10.1016/j.pedn.2007.04.010.

    Article  PubMed  Google Scholar 

  89. Wente SJ. Nonpharmacologic pediatric pain management in emergency departments: a systematic review of the literature. J Emerg Nurs. 2013;39(2):140–50. doi:10.1016/j.jen.2012.09.011.

    Article  PubMed  Google Scholar 

  90. Stephens BK, Barkey ME, Hall HR. Techniques to comfort children during stressful procedures. Accid Emerg Nurs. 1999;7(4):226–36.

    Article  CAS  PubMed  Google Scholar 

  91. Taddio A, Shah V, McMurtry CM, MacDonald NE, Ipp M, Riddell RP, et al. Procedural and physical interventions for vaccine injections: systematic review of randomized controlled trials and quasi-randomized controlled trials. Clin J Pain. 2015;31(10 Suppl):S20–37. doi:10.1097/ajp.0000000000000264.

    Article  PubMed  Google Scholar 

  92. Chambers CT, Taddio A, Uman LS, McMurtry CM. Psychological interventions for reducing pain and distress during routine childhood immunizations: a systematic review. Clin Ther. 2009;31(Suppl 2):S77–103. doi:10.1016/j.clinthera.2009.07.023.

    Article  PubMed  Google Scholar 

  93. Koller D, Goldman RD. Distraction techniques for children undergoing procedures: a critical review of pediatric research. J Pediatr Nurs. 2012;27(6):652–81. doi:10.1016/j.pedn.2011.08.001.

    Article  PubMed  Google Scholar 

  94. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;(1):CD001069. doi:10.1002/14651858.CD001069.pub3.

  95. Kassab M, Foster JP, Foureur M, Fowler C. Sweet-tasting solutions for needle-related procedural pain in infants one month to one year of age. Cochrane Database Syst Rev. 2012;12:CD008411. doi:10.1002/14651858.CD008411.pub2.

    PubMed  Google Scholar 

  96. Harrison D, Yamada J, Adams-Webber T, Ohlsson A, Beyene J, Stevens B. Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years. Cochrane Database Syst Rev. 2011;10:CD008408. doi:10.1002/14651858.CD008408.pub2.

    PubMed  Google Scholar 

  97. Taddio A, Yiu A, Smith RW, Katz J, McNair C, Shah V. Variability in clinical practice guidelines for sweetening agents in newborn infants undergoing painful procedures. Clin J Pain. 2009;25(2):153–5. doi:10.1097/AJP.0b013e3181847a09.

    Article  PubMed  Google Scholar 

  98. Ali S, McGrath T, Drendel AL. An evidence-based approach to minimizing acute procedural pain in the emergency department and beyond. Pediatr Emerg Care. 2016;32(1):36–42. doi:10.1097/pec.0000000000000669.

    Article  PubMed  Google Scholar 

  99. Anonymous. Sucrose (oral) for procedural pain management in infants. 2015. http://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Sucrose_oral_for_procedural_pain_management_in_infants/. Accessed 31 Mar 2016.

  100. Rogers TL, Ostrow CL. The use of EMLA cream to decrease venipuncture pain in children. J Pediatr Nurs. 2004;19(1):33–9.

    Article  PubMed  Google Scholar 

  101. Lander JA, Weltman BJ, So SS. EMLA and amethocaine for reduction of children’s pain associated with needle insertion. Cochrane Database Syst Rev. 2006;(3):CD004236. doi:10.1002/14651858.CD004236.pub2.

  102. Poonai N, Alawi K, Rieder M, Lynch T, Lim R. A comparison of amethocaine and liposomal lidocaine cream as a pain reliever before venipuncture in children: a randomized control trial. Pediatr Emerg Care. 2012;28(2):104–8. doi:10.1097/PEC.0b013e3182442c3b.

    PubMed  Google Scholar 

  103. Eichenfield LF, Funk A, Fallon-Friedlander S, Cunningham BB. A clinical study to evaluate the efficacy of ELA-Max (4 % liposomal lidocaine) as compared with eutectic mixture of local anesthetics cream for pain reduction of venipuncture in children. Pediatrics. 2002;109(6):1093–9.

    Article  PubMed  Google Scholar 

  104. Koh JL, Harrison D, Myers R, Dembinski R, Turner H, McGraw T. A randomized, double-blind comparison study of EMLA and ELA-Max for topical anesthesia in children undergoing intravenous insertion. Paediatr Anaesth. 2004;14(12):977–82. doi:10.1111/j.1460-9592.2004.01381.x.

    Article  PubMed  Google Scholar 

  105. Kleiber C, Sorenson M, Whiteside K, Gronstal BA, Tannous R. Topical anesthetics for intravenous insertion in children: a randomized equivalency study. Pediatrics. 2002;110(4):758–61.

    Article  PubMed  Google Scholar 

  106. Taddio A, Soin HK, Schuh S, Koren G, Scolnik D. Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: a randomized controlled trial. CMAJ. 2005;172(13):1691–5. doi:10.1503/cmaj.045316.

    Article  PubMed  PubMed Central  Google Scholar 

  107. Brenner SM, Rupp V, Boucher J, Weaver K, Dusza SW, Bokovoy J. A randomized, controlled trial to evaluate topical anesthetic for 15 minutes before venipuncture in pediatrics. Am J Emerg Med. 2013;31(1):20–5. doi:10.1016/j.ajem.2012.05.003.

    Article  PubMed  Google Scholar 

  108. Taddio A, Shah V, Stephens D, Parvez E, Hogan ME, Kikuta A, et al. Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newborns. Pediatrics. 2011;127(4):e940–7. doi:10.1542/peds.2010-2914.

    Article  PubMed  Google Scholar 

  109. Anonymous. Protocole d’utilisation de la crème anesthésiante. 2013. http://pediadol.org/Protocole-d-utilisation-de-EMLA-R,289.html. Accessed 26 Feb 2016.

  110. Anonymous. Anesthésiques topiques. 2016. http://www.urgencehsj.ca/wp-content/uploads/Anesth%C3%A9siques-topiques.jpg. Accessed 26 Feb 2016.

  111. Anonymous. Intravenous access—peripheral. 2016. http://www.rch.org.au/clinicalguide/guideline_index/Intravenous_access_Peripheral/. Accessed 5 April 2016.

  112. Hee HI, Goy RW, Ng AS. Effective reduction of anxiety and pain during venous cannulation in children: a comparison of analgesic efficacy conferred by nitrous oxide, EMLA and combination. Paediatr Anaesth. 2003;13(3):210–6.

    Article  PubMed  Google Scholar 

  113. Vetter TR. A comparison of EMLA cream versus nitrous oxide for pediatric venous cannulation. J Clin Anesth. 1995;7(6):486–90.

    Article  CAS  PubMed  Google Scholar 

  114. Robinson PA, Carr S, Pearson S, Frampton C. Lignocaine is a better analgesic than either ethyl chloride or nitrous oxide for peripheral intravenous cannulation. Emerg Med Australas. 2007;19(5):427–32. doi:10.1111/j.1742-6723.2007.01008.x.

    Article  PubMed  Google Scholar 

  115. Farion KJ, Splinter KL, Newhook K, Gaboury I, Splinter WM. The effect of vapocoolant spray on pain due to intravenous cannulation in children: a randomized controlled trial. CMAJ. 2008;179(1):31–6. doi:10.1503/cmaj.070874.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Waterhouse MR, Liu DR, Wang VJ. Cryotherapeutic topical analgesics for pediatric intravenous catheter placement: ice versus vapocoolant spray. Pediatr Emerg Care. 2013;29(1):8–12. doi:10.1097/PEC.0b013e31827b214b.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Ramsook C, Kozinetz CA, Moro-Sutherland D. Efficacy of ethyl chloride as a local anesthetic for venipuncture and intravenous cannula insertion in a pediatric emergency department. Pediatr Emerg Care. 2001;17(5):341–3.

    Article  CAS  PubMed  Google Scholar 

  118. Costello M, Ramundo M, Christopher NC, Powell KR. Ethyl vinyl chloride vapocoolant spray fails to decrease pain associated with intravenous cannulation in children. Clin Pediatr (Phila). 2006;45(7):628–32. doi:10.1177/0009922806291013.

    Article  PubMed  Google Scholar 

  119. Davies EH, Molloy A. Comparison of ethyl chloride spray with topical anaesthetic in children experiencing venepuncture. Paediatr Nurs. 2006;18(3):39–43. doi:10.7748/paed2006.04.18.3.39.c8136.

    Article  PubMed  Google Scholar 

  120. Soueid A, Richard B. Ethyl chloride as a cryoanalgesic in pediatrics for venipuncture. Pediatr Emerg Care. 2007;23(6):380–3. doi:10.1097/01.pec.0000278396.25129.3f.

    Article  PubMed  Google Scholar 

  121. Baxter AL, Cohen LL, McElvery HL, Lawson ML, von Baeyer CL. An integration of vibration and cold relieves venipuncture pain in a pediatric emergency department. Pediatr Emerg Care. 2011;27(12):1151–6. doi:10.1097/PEC.0b013e318237ace4.

    Article  PubMed  Google Scholar 

  122. Lunoe MM, Drendel AL, Levas MN, Weisman SJ, Dasgupta M, Hoffmann RG, et al. A randomized clinical trial of jet-injected lidocaine to reduce venipuncture pain for young children. Ann Emerg Med. 2015;66(5):466–74. doi:10.1016/j.annemergmed.2015.04.003.

    Article  PubMed  Google Scholar 

  123. Lunoe MM, Drendel AL, Brousseau DC. The use of the needle-free jet injection system with buffered lidocaine device does not change intravenous placement success in children in the emergency department. Acad Emerg Med. 2015;22(4):447–51. doi:10.1111/acem.12629.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Auerbach M, Tunik M, Mojica M. A randomized, double-blind controlled study of jet lidocaine compared to jet placebo for pain relief in children undergoing needle insertion in the emergency department. Acad Emerg Med. 2009;16(5):388–93. doi:10.1111/j.1553-2712.2009.00401.x.

    Article  PubMed  Google Scholar 

  125. Leahy S, Kennedy RM, Hesselgrave J, Gurwitch K, Barkey M, Millar TF. On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals. Pediatrics. 2008;122(Suppl 3):S161–70. doi:10.1542/peds.2008-1055i.

    Article  PubMed  Google Scholar 

  126. Friedrichsdorf SJ. Reducing and eliminating procedural pain related to needles: the four essential (non-negotiable) components. http://blog.apsoc.org.au/2014/08/21/reducing-and-eliminating-procedural-pain-related-to-needles-the-four-essential-non-negotiable-components/. Accessed 18 Feb 2016.

  127. Taddio A, Appleton M, Bortolussi R, Chambers C, Dubey V, Halperin S, et al. Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline (summary). Can Med Assoc J. 2010;182(18):1989–95. doi:10.1503/cmaj.092048.

    Article  Google Scholar 

  128. Taddio A, McMurtry CM, Shah V, Riddell RP, Chambers CT, Noel M, et al. Reducing pain during vaccine injections: clinical practice guideline. Can Med Assoc J. 2015;187(13):975–82. doi:10.1503/cmaj.150391.

    Article  Google Scholar 

  129. Young SJ, Barnett PL, Oakley EA. 10. Bruising, abrasions and lacerations: minor injuries in children I. Med J Australia. 2005;182(11):588–92.

    PubMed  Google Scholar 

  130. Lawton B, Hadj A. Laceration repair in children. Aust Fam Physician. 2014;43(9):600–2.

    PubMed  Google Scholar 

  131. Sinha M, Christopher NC, Fenn R, Reeves L. Evaluation of nonpharmacologic methods of pain and anxiety management for laceration repair in the pediatric emergency department. Pediatrics. 2006;117(4):1162–8. doi:10.1542/peds.2005-1100.

    Article  PubMed  Google Scholar 

  132. Ha YO, Kim HS. The effects of audiovisual distraction on children’s pain during laceration repair. Int J Nurs Pract. 2013;19(Suppl 3):20–7. doi:10.1111/ijn.12165.

    Article  PubMed  Google Scholar 

  133. McNulty RJ, Handley TP, Devlin MF. Reducing the need for general anaesthesia in children: use of LAT gel in treating facial lacerations. Br J Oral Maxillofac Surg. 2013;51(6):e130–1. doi:10.1016/j.bjoms.2012.04.259.

    Article  PubMed  Google Scholar 

  134. Eidelman A, Weiss JM, Baldwin CL, Enu IK, McNicol ED, Carr DB. Topical anaesthetics for repair of dermal laceration. Cochrane Database Syst Rev. 2011;(6):CD005364. doi:10.1002/14651858.CD005364.pub2.

  135. Farion K, Osmond MH, Hartling L, Russell K, Klassen T, Crumley E, et al. Tissue adhesives for traumatic lacerations in children and adults. Cochrane Database Syst Rev. 2002;(3):CD003326. doi:10.1002/14651858.cd003326.

  136. Singer AJ, Quinn JV, Hollander JE. The cyanoacrylate topical skin adhesives. Am J Emerg Med. 2008;26(4):490–6. doi:10.1016/j.ajem.2007.05.015.

    Article  PubMed  Google Scholar 

  137. Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. Efficacy of pain control with topical lidocaine-epinephrine-tetracaine during laceration repair with tissue adhesive in children: a randomized controlled trial. CMAJ. 2013;185(13):E629–34. doi:10.1503/cmaj.130269.

    Article  PubMed  PubMed Central  Google Scholar 

  138. Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R. Adjusting the pH of lidocaine for reducing pain on injection. Cochrane Database Syst Rev. 2010;(12):CD006581. doi:10.1002/14651858.CD006581.pub2.

  139. Frank SG, Lalonde DH. How acidic is the lidocaine we are injecting, and how much bicarbonate should we add? Can J Plast Surg. 2012;20(2):71–3.

    PubMed  PubMed Central  Google Scholar 

  140. Hogan ME, vanderVaart S, Perampaladas K, Machado M, Einarson TR, Taddio A. Systematic review and meta-analysis of the effect of warming local anesthetics on injection pain. Ann Emerg Med. 2011;58(1):86–98 e1. doi:10.1016/j.annemergmed.2010.12.001.

  141. Al-Abdullah T, Plint AC, Fergusson D. Absorbable versus nonabsorbable sutures in the management of traumatic lacerations and surgical wounds: a meta-analysis. Pediatr Emerg Care. 2007;23(5):339–44. doi:10.1097/01.pec.0000270167.70615.5a.

    Article  PubMed  Google Scholar 

  142. Cohen LL, Lemanek K, Blount RL, Dahlquist LM, Lim CS, Palermo TM, et al. Evidence-based assessment of pediatric pain. J Pediatr Psychol. 2008;33(9):939–55. doi:10.1093/jpepsy/jsm103.

    Article  PubMed  Google Scholar 

  143. Stewart B, Lancaster G, Lawson J, Williams K, Daly J. Validation of the alder hey triage pain score. Arch Dis Child. 2004;89(7):625–30. doi:10.1136/adc.2003.032599.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. McGrath PJ, Johnson G, Goodman JT, Schillinger J, Dunn J, Chapman J. CHEOPS: a behavioral scale for rating postoperative pain in children. In: Fields HL, Dubner R, Cervero F, editors. Advances in pain research and therapy. New York: Raven Press; 1985. p. 395–402.

    Google Scholar 

  145. Merkel SI, Voepel-Lewis T, Shayevitz JR, Malviya S. The FLACC: a behavioral scale for scoring postoperative pain in young children. Pediatr Nurs. 1997;23(3):293–7.

    CAS  PubMed  Google Scholar 

  146. Bieri D, Reeve RA, Champion GD, Addicoat L, Ziegler JB. The Faces Pain Scale for the self-assessment of the severity of pain experienced by children: development, initial validation, and preliminary investigation for ratio scale properties. Pain. 1990;41(2):139–50.

    Article  CAS  PubMed  Google Scholar 

  147. Beyer JE, Aradine CR. Content validity of an instrument to measure young children’s perceptions of the intensity of their pain. J Pediatr Nurs. 1986;1(6):386–95.

    CAS  PubMed  Google Scholar 

  148. Wong DL, Baker CM. Pain in children: comparison of assessment scales. Pediatr Nurs. 1988;14(1):9–17.

    CAS  PubMed  Google Scholar 

  149. McGrath PA, Seifert CE, Speechley KN, Booth JC, Stitt L, Gibson MC. A new analogue scale for assessing children’s pain: an initial validation study. Pain. 1996;64(3):435–43.

    Article  CAS  PubMed  Google Scholar 

  150. Scott PJ, Ansell BM, Huskisson EC. Measurement of pain in juvenile chronic polyarthritis. Ann Rheum Dis. 1977;36(2):186–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

The authors acknowledge Denis Lebel, BPharm MSc, for reviewing Tables 2 and 3, and Dr. Barbara Cummins McManus for reviewing the manuscript.

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Correspondence to Benoit Bailey.

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Drs. Bailey and Trottier have no conflicts of interest that are directly relevant to the content of this review/study.

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Bailey, B., Trottier, E.D. Managing Pediatric Pain in the Emergency Department. Pediatr Drugs 18, 287–301 (2016). https://doi.org/10.1007/s40272-016-0181-5

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