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Ferric Carboxymaltose: A Review in Iron Deficiency

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Abstract

Intravenous ferric carboxymaltose (Ferinject®; Injectafer®) is a colloidal solution of nanoparticles which consist of a polynuclear iron (III)-(oxyhydr)oxide core stabilized by carboxymaltose and may be given as a single high-dose, 15-min infusion. This article reviews the clinical use of ferric carboxymaltose in various patient populations with iron deficiency (ID) [± anaemia] and briefly summarizes its pharmacological properties. Based on extensive experience in the clinical trial and real-world settings, ferric carboxymaltose is an effective and generally well tolerated treatment for rapidly replenishing iron stores and correcting anaemia in patients with ID (± anaemia) of various aetiologies, including patients with chronic heart failure (CHF), chronic kidney disease, inflammatory bowel disease or perioperative anaemia, and women with ID during pregnancy, postpartum or associated with heavy uterine bleeding. As it may be given as a single high-dose infusion, ferric carboxymaltose has the potential to provide cost savings from a healthpayer perspective. Thus, ferric carboxymaltose remains an important option for the treatment of ID in adults and, where approved, children aged ≥ 14 years, when oral iron preparations are ineffective or cannot be used.

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References

  1. Peyrin-Biroulet L, Williet N, Cacoub P. Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review. Am J Clin Nutr. 2015;102(6):1585–94.

    Article  CAS  PubMed  Google Scholar 

  2. Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832–43.

    Article  PubMed  Google Scholar 

  3. Cappellini MD, Comin-Colet J, De Francisco A, et al. Iron deficiency across chronic inflammatory conditions: international expert opinion on definition, diagnosis, and management. Am J Hematol. 2017;92:1068–78.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Dignass AU, Gasche C, Bettenworth D, et al. European consensus on the diagnosis and management of iron deficiency and anaemia in inflammatory bowel diseases. J Crohns Colitis. 2015;9(3):211–22.

    Article  PubMed  Google Scholar 

  5. Baird-Gunning J, Bromley J. Correcting iron deficiency. Aust Prescr. 2016;39(6):193–9.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Eur J Heart Fail. 2016;18:891–975.

    Article  PubMed  Google Scholar 

  7. Mũnoz M, Gómez-Ramírez S, Besser M, et al. Current misconceptions in diagnosis and management of iron deficiency. Blood Transfus. 2017;15:422–37.

    PubMed  PubMed Central  Google Scholar 

  8. Keating GM. Ferric carboxymaltose: a review of its use in iron deficiency. Drugs. 2015;75(1):101–27.

    Article  CAS  PubMed  Google Scholar 

  9. American Regent Inc. Injectafer® (ferric carboxymaltose injection): US prescribing information. 2013. http://www.fda.gov. Accessed 6 Feb 2018.

  10. Vifor Pharma UK Limited. Ferinject (ferric carboxymaltose): UK summary of product characteristics. 2017. http://www.medicines.org.uk. Accessed 9 Feb 2018.

  11. Anker SD, Comin Colet J, Filippatos G, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009;361(25):2436–48.

    Article  CAS  PubMed  Google Scholar 

  12. Ponikowski P, van Veldhuisen DJ, Comin-Colet J, et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur Heart J. 2015;36(11):657–68.

    Article  CAS  PubMed  Google Scholar 

  13. van Veldhuisen DJ, Ponikowski P, van der Meer P, et al. Effect of ferric carboxymaltose on exercise capacity in patients with chronic heart failure and iron deficiency. Circulation. 2017;136(15):1374–83.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Comin-Colet J, Lainscak M, Dickstein K, et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. Eur Heart J. 2013;34(1):30–8.

    Article  CAS  PubMed  Google Scholar 

  15. Filippatos G, Farmakis D, Colet JC, et al. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. Eur J Heart Fail. 2013;15(11):1267–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Jankowska EA, Tkaczyszyn M, Suchocki T, et al. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials. Eur J Heart Fail. 2016;18(7):786–95.

    Article  CAS  PubMed  Google Scholar 

  17. Ponikowski P, Filippatos G, Colet JC, et al. The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study. Eur J Heart Fail. 2015;17(3):329–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Charytan C, Bernardo MV, Koch TA, et al. Intravenous ferric carboxymaltose versus standard medical care in the treatment of iron deficiency anemia in patients with chronic kidney disease: a randomized, active-controlled, multi-center study. Nephrol Dial Transplant. 2013;28(4):953–64.

    Article  CAS  PubMed  Google Scholar 

  19. Macdougall IC, Bock AH, Carrera F, et al. FIND-CKD: a randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia. Nephrol Dial Transplant. 2014;29(11):2075–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Onken JE, Bregman DB, Harrington RA, et al. Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: the REPAIR-IDA trial. Nephrol Dial Transplant. 2014;29(4):833–42.

    Article  CAS  PubMed  Google Scholar 

  21. Qunibi WY, Martinez C, Smith M, et al. A randomized controlled trial comparing intravenous ferric carboxymaltose with oral iron for treatment of iron deficiency anaemia of non-dialysis-dependent chronic kidney disease patients. Nephrol Dial Transplant. 2011;26(5):1599–607.

    Article  CAS  PubMed  Google Scholar 

  22. Macdougall IC, Bock AH, Carrera F, et al. Renal function in patients with non-dialysis chronic kidney disease receiving intravenous ferric carboxymaltose: an analysis of the randomized FIND-CKD trial. BMC Nephrol. 2017;18(24):1–18.

    Google Scholar 

  23. Benjamin J, Qunibi WY. Comparison of intravenous (IV) ferric carboxymaltose (FCM) to oral iron in anemic non-dialysis dependent-CKD patients with or without ESA therapies [abstract no. SA-PO2422]. J Am Soc Nephrol. 2009;20(Suppl):666A.

    Google Scholar 

  24. MacDougall IC, Bock AH, Carrera F, et al. Erythropoietic response to oral iron in patients with nondialysis-dependent chronic kidney disease in the FIND-CKD trial. Clin Nephrol. 2017;88(6):301–10.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Kulnigg S, Stoinov S, Simanenkov V, et al. A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: the ferric carboxymaltose (FERINJECT®) randomized controlled trial. Am J Gastroenterol. 2008;103(5):1182–92.

    Article  CAS  PubMed  Google Scholar 

  26. Evstatiev R, Marteau P, Iqbal T, et al. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. Gastroenterology. 2011;141(3):846–53.e1-2.

  27. Evstatiev R, Alexeeva O, Bokemeyer B, et al. Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11(3):269–77.

    Article  CAS  PubMed  Google Scholar 

  28. Befrits R, Wikman O, Blomquist L, et al. Anemia and iron deficiency in inflammatory bowel disease: an open, prospective, observational study on diagnosis, treatment with ferric carboxymaltose and quality of life. Scand J Gastroenterol. 2013;48(9):1027–32.

    Article  CAS  PubMed  Google Scholar 

  29. Stein J, Vollmer S, Klemm W, et al. Safety and efficacy of Ferinject® in the treatment of IBD-related iron deficiency anaemia under daily practice conditions: results from a non-interventional post-marketing surveillance study in Germany [abstract no. P0881]. United Eur Gastroenterol J. 2016;3(5 Suppl.):A456–7.

    Google Scholar 

  30. Breymann C, Gliga F, Bejenariu C, et al. Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. Int J Gynaecol Obstet. 2008;101(1):67–73.

    Article  CAS  PubMed  Google Scholar 

  31. Seid MH, Derman RJ, Baker JB, et al. Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial. Am J Obstet Gynecol. 2008;199(4):435.e1-7.

    Article  PubMed  Google Scholar 

  32. Van Wyck DB, Martens MG, Seid MH, et al. Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial. Obstet Gynecol. 2007;110(2 Pt 1):267–78.

    Article  PubMed  Google Scholar 

  33. Breymann C, Milman N, Mezzacasa A, et al. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med. 2017;45(4):443–53.

    Article  CAS  PubMed  Google Scholar 

  34. Van Wyck DB, Mangione A, Morrison J, et al. Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial. Transfusion. 2009;49(12):2719–28.

    Article  PubMed  Google Scholar 

  35. Favrat B, Balck K, Breymann C, et al. Evaluation of a single dose of ferric carboxymaltose in fatigued, iron-deficient women: PREFER a randomized, placebo-controlled study. PLoS ONE. 2014;9(4):e94217.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Schneider J, Krafft A, Manconi M, et al. Open-label study of the efficacy and safety of intravenous ferric carboxymaltose in pregnant women with restless legs syndrome. Sleep Med. 2015;16(11):1342–7.

    Article  PubMed  Google Scholar 

  37. Herfs R, Fleitmann L, Kocsis I. Treatment of iron deficiency with or without anaemia with intravenous ferric carboxymaltose in gynaecological practices: a non-interventional study. Geburtshilfe Frauenheilkd. 2014;74(1):81–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Seid MH, Butcher AD, Chatwani A. Ferric carboxymaltose as treatment in women with iron-deficiency anemia. Anemia. 2017. https://doi.org/10.1155/2017/9642027.

    PubMed  PubMed Central  Google Scholar 

  39. Khalafallah AA, Yan C, Al-Badri R, et al. Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial. Lancet Haematol. 2016;3(9):e415–25.

    Article  PubMed  Google Scholar 

  40. Bisbe E, Moltó L, Arroyo R, et al. Randomized trial comparing ferric carboxymaltose vs oral ferrous glycine sulphate for postoperative anaemia after total knee arthroplasty. Br J Anaesth. 2014;113(3):402–9.

    Article  CAS  PubMed  Google Scholar 

  41. Bernabeu-Wittel M, Romero M, Ollero-Baturone M, et al. Ferric carboxymaltose with or without erythropoietin in anemic patients with hip fracture: a randomized clinical trial. Transfusion. 2016;56(9):2199–211.

    Article  CAS  PubMed  Google Scholar 

  42. Bisbe E, García-Erce JA, Díez-Lobo AI, et al. A multicentre comparative study on the efficacy of intravenous ferric carboxymaltose and iron sucrose for correcting preoperative anaemia in patients undergoing major elective surgery. Br J Anaesth. 2011;107(3):477–8.

    Article  CAS  PubMed  Google Scholar 

  43. Calleja JL, Delgado S, del Val A, et al. Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia. Int J Colorectal Dis. 2016;31(3):543–51.

    Article  PubMed  Google Scholar 

  44. Steinmetz T, Tschechne B, Harlin O, et al. Clinical experience with ferric carboxymaltose in the treatment of cancer- and chemotherapy-associated anaemia. Ann Oncol. 2013;24(2):475–82.

    Article  CAS  PubMed  Google Scholar 

  45. Toledano A, Luporsi E, Morere JF, et al. Clinical use of ferric carboxymaltose in patients with solid tumours or haematological malignancies in France. Support Care Cancer. 2016;24(1):67–75.

    Article  PubMed  Google Scholar 

  46. Barish CF, Koch T, Butcher A, et al. Safety and efficacy of intravenous ferric carboxymaltose (750 mg) in the treatment of iron deficiency anemia: two randomized, controlled trials. Anemia. 2012. https://doi.org/10.1155/2012/172104.

    PubMed  PubMed Central  Google Scholar 

  47. Onken JE, Bregman DB, Harrington RA, et al. A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia. Transfusion. 2014;54(2):306–15.

    CAS  PubMed  Google Scholar 

  48. Hussain I, Bhoyroo J, Butcher A, et al. Direct comparison of the safety and efficacy of ferric carboxymaltose versus iron dextran in patients with iron deficiency anemia. Anemia. 2013. https://doi.org/10.1155/2013/169107.

    PubMed  PubMed Central  Google Scholar 

  49. Investigators The Ironman, Litton E, Baker S, et al. Intravenous iron or placebo for anaemia in intensive care: the IRONMAN multicentre randomized blinded trial. Intensive Care Med. 2016;42(11):1715–22.

    Article  Google Scholar 

  50. Allen RP, Adler CH, Du W, et al. Clinical efficacy and safety of IV ferric carboxymaltose (FCM) treatment of RLS: a multi-centered, placebo-controlled preliminary clinical trial. Sleep Med. 2011;12(9):906–13.

    Article  PubMed  Google Scholar 

  51. Cho YW, Allen RP, Earley CJ. Clinical efficacy of ferric carboxymaltose treatment in patients with restless legs syndrome. Sleep Med. 2016;25:16–23.

    Article  PubMed  Google Scholar 

  52. Trenkwalder C, Winkelmann J, Oertel W, et al. Ferric carboxymaltose in patients with restless legs syndrome and nonanemic iron deficiency: a randomized trial. Mov Disord. 2017;32(10):1478–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Schatz U, Illigens BM, Siepmann T, et al. TIDILAP: treatment of iron deficiency in lipoprotein apheresis patients. A prospective observational multi-center cohort study comparing efficacy, safety and tolerability of ferric gluconate with ferric carboxymaltose. Atheroscler Suppl. 2015;18:199–208.

    Article  CAS  PubMed  Google Scholar 

  54. Quintana-Diaz M, Fabra-Cadenas S, Gomez-Ramirez S, et al. A fast-track anaemia clinic in the emergency department: feasibility and efficacy of intravenous iron administration for treating sub-acute iron deficiency anaemia. Blood Transfus. 2016;14(2):126–33.

    PubMed  PubMed Central  Google Scholar 

  55. Kuster M, Meli DN. Treatment of iron deficiency with intravenous ferric carboxymaltose in general practice: a retrospective database study. J Clin Med Res. 2015;7(1):37–40.

    Article  PubMed  Google Scholar 

  56. Robalo Nunes A, Palricas Costa A, Rocha SL, et al. Efficacy and tolerability of intravenous ferric carboxymaltose in patients with iron deficiency at a hospital outpatient clinic: a retrospective cohort study of real-world clinical practice. Anemia. 2017. https://doi.org/10.1155/2017/3106890.

    PubMed  PubMed Central  Google Scholar 

  57. Bach M, Geisel T, Martin J, et al. Efficacy and safety of intravenous ferric carboxymaltose in geriatric inpatients at a German tertiary university teaching hospital: a retrospective observational cohort study of clinical practice. Anemia. 2015. https://doi.org/10.1155/2015/647930.

    PubMed  PubMed Central  Google Scholar 

  58. Blazevic A, Hunze J, Boots JMM. Severe hypophosphataemia after intravenous iron administration. Neth J Med. 2014;72(1):49–53.

    CAS  PubMed  Google Scholar 

  59. Sánchez González R, Ternavasio-de la Vega HG, Moralejo Alonso L, et al. Intravenous ferric carboxymaltose-associated hypophosphatemia in patients with iron deficiency anemia: a common side effect. Med Clin. 2015;145(3):108–11.

    Article  Google Scholar 

  60. Schaefer B, Wurtinger P, Finkenstedt A, et al. Choice of high-dose intravenous iron preparation determines hypophosphatemia risk. PLoS ONE. 2016;11(12):e0167146.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Hardy S, Vandemergel X. Intravenous iron administration and hypophosphatemia in clinical practice. Int J Rheumatol. 2015;2015(468675):1–6.

    Article  CAS  Google Scholar 

  62. Bager P, Hvas CL, Dahlerup JF. Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions. Br J Clin Pharmacol. 2017;83(5):1118–25.

    Article  CAS  PubMed  Google Scholar 

  63. Schaefer B, Glodny B, Wolf M, et al. Letter: inconsistency in reporting of hypophosphataemia after intravenous iron. Aliment Pharmacol Ther. 2017;46(6):641–3.

    Article  CAS  PubMed  Google Scholar 

  64. Anker SD, Kirwan BA, van Veldhuisen DJ, et al. Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis. Eur J Heart Fail. 2018;20(1):125–33.

    Article  CAS  PubMed  Google Scholar 

  65. Roger SD, Gaillard CA, Bock AH, et al. Safety of intravenous ferric carboxymaltose versus oral iron in patients with nondialysis-dependent CKD: an analysis of the 1-year FIND-CKD trial. Nephrol Dial Transplant. 2017;32:1530–9.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Mücke V, Mücke MM, Raine T, et al. Diagnosis and treatment of anemia in patients with inflammatory bowel disease. Ann Gastroenterol. 2017;30(1):15–22.

    PubMed  Google Scholar 

  67. Cappellini MD, Comin-Colet J, Francisco A, et al. Iron deficiency across chronic inflammatory conditions: international expert opinion on definition, diagnosis, and management. Am J Hepatol. 2017;92(10):1068–78.

    CAS  Google Scholar 

  68. Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. J Card Fail. 2017;23(8):628–51.

    Article  PubMed  Google Scholar 

  69. Macdougall IC, Bircher AJ, Eckardt KU, et al. Iron management in chronic kidney disease: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference. Kidney Int. 2016;89(1):28–39.

    Article  CAS  PubMed  Google Scholar 

  70. Wish JB. What are the considerations in balancing benefits and risks in iron treatment? The benefits of intravenous iron. Semin Dial. 2017;30(1):20–2.

    Article  PubMed  Google Scholar 

  71. Mikhail A, Brown C, Williams JA, et al. Renal association clinical practice guideline on anaemia in chronic kidney disease. BMC Nephrol. 2017;18:345.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of iron deficiency anemia. Gastroenterol Hepatol. 2015;11(4):241–50.

    Google Scholar 

  73. Api O, Breyman C, Cetiner M, et al. Diagnosis and treatment of iron deficiency anemia during pregnancy and the postpartum period: iron deficiency anemia working group consensus report. Turk J Obstet Gynecol. 2015;12(3):173–81.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Muñoz M, Gómez-Ramírez S, Campos A, et al. Pre-operative anaemia: prevalence, consequences and approaches to management. Blood Transfus. 2015;13(3):370–9.

    PubMed  PubMed Central  Google Scholar 

  75. Drozd M, Jankowska EA, Banasiak W, et al. Iron therapy in patients with heart failure and iron deficiency: review of iron preparations for practitioners. Am J Cardiovasc Drugs. 2017;17(3):183–201.

    Article  CAS  PubMed  Google Scholar 

  76. Valerio de Azevedo S, Maltez C, Lopes AI. Pediatric Crohn’s disease, iron deficiency anemia and intravenous iron treatment: a follow-up study. Scand J Gastroenterol. 2017;52(1):29–33.

    Article  CAS  PubMed  Google Scholar 

  77. Laass MW, Straub S, Chainey S, et al. Effectiveness and safety of ferric carboxymaltose treatment in children and adolescents with inflammatory bowel disease and other gastrointestinal diseases. BMC Gastroenterol. 2014;14(1):184.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Favreau A, Langseder A, Neier M, et al. Safety and efficacy of ferric carboxymaltose in pediatric inflammatory bowel disease [abstract no. PD-198]. Inflamm Bowel Dis. 2017;23(Suppl. 1):S66.

    Google Scholar 

  79. Powers JM, Shamoun M, McCavit TL, et al. Intravenous ferric carboxymaltose in children with iron deficiency anemia who respond poorly to oral iron. J Pediatr. 2017;180:212–6.

    Article  CAS  PubMed  Google Scholar 

  80. Papadopoulos M, Patel D, Korologou-Linden R, et al. Safety and efficacy of parenteral iron in children with inflammatory bowel disease. Br J Clin Pharmacol. 2017. https://doi.org/10.1111/bcp.13493.

    Google Scholar 

  81. Walter E, Lazic-Peric A, Schaefer B. Cost-effectiveness of ferric carboxymaltose (FCM) in the treatment of iron deficiency in patients with inflammatory bowel disease (IBD) [abstract no. PG119]. Value Health. 2017;20(9):A634–5.

    Article  Google Scholar 

  82. Levesque K, Delahaye D, Caranhac G. Cost savings of perioperative anemia treatment with ferric carboxymaltose in colorectal cancer surgery patients [abstract no. PSY71]. Value Health. 2017;20(9):A557.

    Article  Google Scholar 

  83. Froessler B, Foerster D, Hardt T, et al. Treatment cost effects of perioperative anaemia treatment with ferric carboxymaltose [abstract no. P86]. Transfus Med. 2017;27(Suppl. 1):57.

    Google Scholar 

  84. Bourguignon S, Levesque K, Faller M, et al. Budget impact of IV iron therapy with ferric carboxymaltose in patients with chronic heart failure and iron deficiency in France [abstract no. PCV40]. Value Health. 2017;20(9):A607.

    Article  Google Scholar 

  85. Theidel U, Vaatainen S, Martikainen J, et al. Budget impact of intravenous iron therapy with ferric carboxymaltose in patients with chronic heart failure and iron deficiency in Germany. ESC Heart Fail. 2017;4(3):274–81.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Walter E, Lazic-Peric A, Schalle K. Budget-impact-analysis of iron treatment using intravenous ferric carboxymaltose in patients with iron deficiency anemia in Austria [abstract no. PG19]. Value Health. 2017;20(9):A633.

    Article  Google Scholar 

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Acknowledgements

During the peer review process, the manufacturer of ferric carboxymaltose was also offered an opportunity to review this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.

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Correspondence to Lesley J. Scott.

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The preparation of this review was not supported by any external funding.

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Lesley Scott is a salaried employee of Adis/Springer, is responsible for the article content and declares no relevant conflicts of interest.

Additional information about this Adis Drug Review can be found at http://www.medengine.com/Redeem/312DF06004B89E77.

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The manuscript was reviewed by: A. K. Agrawal, Department of Hematology and Oncology, Children’s Hospital and Research Center Oakland, Oakland, CA, USA; M. Akman, Department of Family Medicine, Marmara University, School of Medicine, Istanbul, Turkey; C. Cerchione, Department of Clinical Medicine and Surgery, Federico II University, Hematology, Naples, Italy; G. Ertl, Department of Internal Medicine I, University of Würzburg, Würzburg, Germany; J. Stein, Gastroenterology and Clinical Nutrition DGD Clinics Sachsenhausen, Frankfurt, Germany.

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Scott, L.J. Ferric Carboxymaltose: A Review in Iron Deficiency. Drugs 78, 479–493 (2018). https://doi.org/10.1007/s40265-018-0885-7

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