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Bacteriophage Polysaccharide Depolymerases and Biomedical Applications

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An Erratum to this article was published on 18 March 2014

Abstract

Polysaccharide depolymerase, a polysaccharide hydrolase encoded by bacteriophages (or ‘phages’), can specifically degrade the macromolecule carbohydrates of the host bacterial envelope. This enzyme assists the bacteriophage in adsorbing, invading, and disintegrating the host bacteria. Polysaccharide depolymerase activity continues even within biofilms. This effectiveness means phages are promising candidates for novel antibiotic scaffolds. A comprehensive compendium of bacteriophage polysaccharide depolymerases has been compiled, together with their potential biomedical applications, such as novel antibiotics, adjuvants for antibiotics, bacterial biofilm disruptants, and diagnostic kits.

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Acknowledgments

This work was supported by the National Natural Science Foundation (grant numbers 81371851,81071316, 81271882), the National Megaprojects for Key Infectious Diseases (grant numbers 2008ZX10003-006), New Century Excellent Talents in Universities (grant number NCET-11-0703), Excellent PhD thesis fellowship of Southwest University (grant numbers kb2010017, ky2011003), the Fundamental Research Funds for the Central Universities (grant numbers XDJK2011D006, XDJK2012D011, XDJK2012D007, and XDJK2013D003), Natural Science Foundation Project of CQ CSTC (grant number CSTC 2010BB5002), The Chongqing Municipal Committee of Education for Postgraduates Excellence Program (grant numbers YJG123104), The Undergraduates Teaching Reform Program (grant numbers 2011JY052).

Conflicts of interest

None.

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Authors and Affiliations

  1. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, 400700, China

    Jianlong Yan, Jiaoxiao Mao & Jianping Xie

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  1. Jianlong Yan
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  2. Jiaoxiao Mao
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  3. Jianping Xie
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Correspondence to Jianping Xie.

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Yan, J., Mao, J. & Xie, J. Bacteriophage Polysaccharide Depolymerases and Biomedical Applications. BioDrugs 28, 265–274 (2014). https://doi.org/10.1007/s40259-013-0081-y

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  • DOI: https://doi.org/10.1007/s40259-013-0081-y

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