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Role of butyrogenic Firmicutes in type-2 diabetes

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Abstract

Objective

The aim of this review is to speculate the pre-clinical and clinical evidences indicating the association between butyrate-synthesizing firmicutes and development and progression of type 2 diabetes mellitus.

Methodology

Literature was searched using ‘Google Scholar’ and ‘PubMed’ to find out most relevant articles for the scope of this review. Information was also gathered from authentic sources such as the World Health Organisation and the International Diabetes Federation.

Results

Evidences suggest that an abnormal perturbation in the gut microbiome characterized by subsided levels of butyrate-producing bacteria may gradually result in the progression of type-2 diabetes; however, the explicit mechanisms underlying and implicating the role of specific butyrate-producing microbes remain unclear.

Conclusions

This review explicitly summarizes the role of butyrate-synthesizing firmicutes known to be reduced in the subjects with type-2 diabetes mellitus in host metabolic health and contemplates the putative and reported mechanisms underlying its implication in the pathophysiology of type-2 diabetes mellitus.

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Data Availability

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Funding

This study was supported/ funded by the Indian Council of Medical Research (DHR-ICMR/GIA/05/18/2020 and ICMR No.5/4/5–12/Diab/21-NCD-III).

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Authors and Affiliations

  1. ICMR- National Institute for Research in Environmental Health, Bhopal Bypass Road, 462030, Bhouri, Bhopal, Madhya Pradesh, India

    Meenu Mariya James, Namrata Pal, Poonam Sharma, Manoj Kumawat, Swasti Shubham, Rajnarayan R Tiwari, Devojit Kumar Sarma & Manoj Kumar

  2. Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, 226014, Lucknow, Uttar Pradesh, India

    Vinod Verma

  3. Indian Veterinary Research Institute, Regional Station, 176061, Palampur, India

    Birbal Singh

  4. Department of Nutrition and Integrative Physiology, Florida State University, 32302, Tallahassee, FL, USA

    Ravinder Nagpal

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  1. Meenu Mariya James
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James, M.M., Pal, N., Sharma, P. et al. Role of butyrogenic Firmicutes in type-2 diabetes. J Diabetes Metab Disord 21, 1873–1882 (2022). https://doi.org/10.1007/s40200-022-01081-5

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