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Image-guided nanomedicine for cancer

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Abstract

Since current treatment options applicable to cancers are still confined to chemotherapeutics followed by surgical debulking, cancer disease is a second leading cause of death because of chemotherapeutics of non-specific biodistribution. Image-guided drug delivery system (IGDDS) is a real-time noninvasive imaging assessment of therapeutic response that has the strong potential to control or suppress cancer because imaging property offer the quantification of nanomedicine at the intended disease site, thus the potential assurance of adequate treatment and elimination of undesirable delay leading to poor clinical outcomes. Also, combining pH-sensitive advantages of nanoparticle with theranostic property will have high chance to overcome cancer. There have been intensive researches to develop innovative IGDDS by using nanoparticles including organic or inorganic theranostic (therapy + diagnostic) systems including liposomes, polymeric micelles, dendrimers, carbon nanotubes, gold nanoparticles, iron oxide nanoparticles, quantum dots, and silica nanoparticles. In this review, we will introduce various examples of each system and will discuss their theranostic applications.

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(Reprinted by permission from (Yang et al. 2010). Copyright 2010 American Chemical Society.)

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(Reprinted by permission from (Xia et al. 2011). Copyright 2010 Elsevier Ltd.)

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(Reprinted by permission from (He et al. 2011). Copyright 2011 Nature Publishing Group.)

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  1. Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, Reynolds Medical Building, Suite 159, Mail Stop 1114, College Station, TX, 77843-1114, USA

    Jong Hoon Choi & Dongin Kim

  2. Nutrition and Food Science Department, Texas A&M University, 2476 TAMU, College Station, TX, 77843-2476, USA

    Yong Jae Lee

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Choi, J.H., Lee, Y.J. & Kim, D. Image-guided nanomedicine for cancer. Journal of Pharmaceutical Investigation 47, 51–64 (2017). https://doi.org/10.1007/s40005-016-0297-1

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