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Nanomedicines for oral administration based on diverse nanoplatform

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Abstract

Nanotechnology has been applied to the oral drug delivery for enhancing bioavailability after oral administration. Numerous forms of reported nanomedicines are classified as lipid based nanomedicine (LBNM), polymer based nanomedicine (PBNM), and nanosuspension. LBNM includes self nano-emulsifying drug delivery systems, liposomes and solid lipid nanoparticle (SLN). PBNM includes polymeric nanoparticles and polymeric micelles. Unlike intravenous administration, oral administration has more complicated barriers that are hard to overcome. The various nanoplatforms described above are used to surmount physical and bio-chemical barriers due to advantageous characteristics of nanoplatforms. The characteristics of nanoplatforms including particle size, stimuli-sensitivity, preventing drug efflux, solubility and permeation of the drug induce the enhanced absorption and high bioavailability. Regardless of passionate researches, some limitations still exist, for instance economic problems, toxicity issue, and development of biopharmaceutic oral nanomedicine. In this review, physiological barriers in oral administration, advantages of nanomedicines, classification of oral nanomedicines, and their challenges are described concisely.

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Acknowledgments

This article does not contain any studies with human and animal subjects performed by any of the authors. And All authors (T Sim, C Lim, NH Hoang, H Joo, JW Lee, D Kim, ES Lee, YS Youn, JO Kim, KT Oh) declare that they have no conflict of interest. This research was supported by a Grant (15182MFDS486) from Ministry of Food and Drug Safety in 2016. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2014R1A2A1A11050094), a grant from the Medical Cluster R&D Support Project of Daegu Gyeongbuk Medical Innovation Foundation, Republic of Korea (2013) (No. HT13C0011).

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  1. College of Pharmacy, Chung-Ang University, 221 Heukseok Dong, Dongjak-gu, Seoul, 156-756, Republic of Korea

    Taehoon Sim, Chaemin Lim, Ngoc Ha Hoang, Hyonsung Joo, Jun Won Lee, Da-won Kim & Kyung Taek Oh

  2. Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon, Gyeonggi-do, 420-743, Republic of Korea

    Eun Seong Lee

  3. College of Pharmacy, SungKyunKwan University, 300 Chonchon-dong, Jangan-ku, Suwon City, 440-746, Republic of Korea

    Yu Seok Youn

  4. College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 712-749, South Korea

    Jong Oh Kim

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Sim, T., Lim, C., Hoang, N.H. et al. Nanomedicines for oral administration based on diverse nanoplatform. Journal of Pharmaceutical Investigation 46, 351–362 (2016). https://doi.org/10.1007/s40005-016-0255-y

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