Skip to main content

Advertisement

SpringerLink
Log in

Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filamentous fungi have been reported as significant pathogens in patients with CGD. We report a case of subcutaneous basidiomycete Phellinus mori infection in a patient with CGD. To the best of our knowledge, this is the first reported case of human infection by this fungus. The causative fungus was identified on the basis of its morphological characteristics and nucleotide sequence on the internal transcribed spacer region of the ribosomal RNA gene. This is the fifth case report of filamentous basidiomycetes infecting a patient with CGD; all of these cases have been caused by Phellinus species. We highlight the importance of recognizing filamentous basidiomycetes Phellinus species as possible agents of non-Aspergillus fungal infections in patients with CGD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Segal BH, Leto TL, Gallin JI, Malech HL, Holland SM. Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore). 2000;79:170–200.

    Article  CAS  Google Scholar 

  2. Seger RA. Modern management of chronic granulomatous disease. Br J Haematol. 2008;140:255–66.

    Article  CAS  PubMed  Google Scholar 

  3. Winkelstein JA, Marino MC, Johnston RB Jr, et al. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore). 2000;79:155–69.

    Article  CAS  Google Scholar 

  4. Holland SM. Chronic granulomatous disease. Clin Rev Allergy Immunol. 2010;38(1):3–10.

    Article  CAS  PubMed  Google Scholar 

  5. Beaute J, Obenga G, Le Mignot L, et al. Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France. Pediatr Infect Dis J. 2011;30:57–62.

    Article  PubMed  Google Scholar 

  6. Shigemura T, Agematsu K, Yamazaki T, et al. Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease. Infection. 2009;37:469–73.

    Article  CAS  PubMed  Google Scholar 

  7. Dai YC, Cui BK, Tao WQ. Phellinus mori sp. nov. (Basidiomycota, Hymenochaetales) from northern China. Mycotaxon. 2008;105:53–8.

    Google Scholar 

  8. Martire B, Rondelli R, Soresina A, et al. Clinical features, long-term follow-up and outcome of a large cohort of patients with chronic granulomatous disease: an Italian multicenter study. Clin Immunol. 2008;126:155–64.

    Article  CAS  PubMed  Google Scholar 

  9. van den Berg JM, van Koppen E, Ahlin A, et al. Chronic granulomatous disease: the European experience. PLoS ONE. 2009;4:e5234.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Kobayashi S, Murayama S, Takanashi S, et al. Clinical features and prognoses of 23 patients with chronic granulomatous disease followed for 21 years by a single hospital in Japan. Eur J Pediatr. 2008;167:1389–94.

    Article  PubMed  Google Scholar 

  11. Dotis J, Pana ZD, Roilides E. Non-Aspergillus fungal infections in chronic granulomatous disease. Mycoses. 2013;56:449–62.

    Article  PubMed  Google Scholar 

  12. Sigler L, de la Maza LM, Tan G, Egger KN, Sherburne RK. Diagnostic difficulties caused by a nonclamped Schizophyllum commune isolate in a case of fungus ball of the lung. J Clin Microbiol. 1995;33:1979–83.

    PubMed Central  CAS  PubMed  Google Scholar 

  13. Pounder JI, Simmon KE, Barton CA, Hohmann SL, Brandt ME, Petti CA. Discovering potential pathogens among fungi identified as nonsporulating molds. J Clin Microbiol. 2007;45:568–71.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Chowdhary A, Agarwal K, Kathuria S, et al. Clinical significance of filamentous basidiomycetes illustrated by isolates of the novel opportunist Ceriporia lacerata from the human respiratory tract. J Clin Microbiol. 2013;51:585–90.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Cao C, Peng F, Cui BK. Chemical characterization and structure of exopolysaccharides from submerged culture of new medicinal mushroom from China, Phellinus mori (higher Basidiomycetes). Int J Med Mushrooms. 2013;15:57–69.

    Article  CAS  PubMed  Google Scholar 

  16. Williamson D, Pandey S, Taylor S, et al. A case of infection caused by the basidiomycete Phellinus undulatus. J Med Microbiol. 2011;60:256–8.

    Article  PubMed  Google Scholar 

  17. Sutton DA, Thompson EH, Rinaldi MG, et al. Identification and first report of Inonotus (Phellinus) tropicalis as an etiologic agent in a patient with chronic granulomatous disease. J Clin Microbiol. 2005;43:982–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Davis CM, Noroski LM, Dishop MK, et al. Basidiomycetous fungal Inonotus tropicalis sacral osteomyelitis in X-linked chronic granulomatous disease. Pediatr Infect Dis J. 2007;26:655–6.

    Article  PubMed  Google Scholar 

  19. Ramesh M, Resnick E, Hui Y, et al. Phellinus tropicalis abscesses in a patient with chronic granulomatous disease. J Clin Immunol. 2014;34:130–3.

    Article  PubMed Central  PubMed  Google Scholar 

  20. De Ravin SS, Parta M, Sutton DA, et al. Paravertebral mushroom: identification of a novel species of Phellinus as a human pathogen in chronic granulomatous disease. J Clin Microbiol. 2014;52:2726–9.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by JSPS KAKENHI Grand Numbers 26860791.

Conflict of interest

We declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan

    T. Shigemura, Y. Nakazawa, N. Kobayashi & K. Koike

  2. Department of Pediatrics, Nagano Red Cross Hospital, Nagano, Japan

    Y. Amano & A. Sudo

  3. Department of Pathology, Nagano Red Cross Hospital, Nagano, Japan

    M. Watanabe

  4. Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan

    M. Kobayashi

  5. Department of Infection and Host Defense, Graduate School of Medicine, Shinshu University, Matsumoto, Japan

    K. Agematsu

  6. Department of Microbiology, Dokkyo Medical University School of Medicine, Tochigi, Japan

    K. Nishimura

Authors
  1. T. Shigemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Nakazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Amano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Sudo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. N. Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. K. Koike
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. K. Agematsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. K. Nishimura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. Nakazawa.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shigemura, T., Nakazawa, Y., Amano, Y. et al. Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease. Infection 43, 371–375 (2015). https://doi.org/10.1007/s15010-015-0724-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-015-0724-7

Keywords

Search

Navigation