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Immunomodulation for Tissue Repair and Regeneration

  • Review Article
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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper understanding of the immune system’s involvement in tissue repair and regeneration is critical for the development of successful reparatory and regenerative strategies. Here we review recent technologies that facilitate cell-based and biomaterial-based modulation of the immune systems for tissue repair and regeneration. First, we summarize the roles of various types of immune cells in tissue repair. Second, we review the principle, examples, and limitations of regulatory T (Treg) cell-based therapy, a representative cell-based immunotherapy. Finally, we discuss biomaterial-based immunotherapy strategies that aim to modulate immune cells using various biomaterials for tissue repair and regeneration.

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Acknowledgements

This study was supported by a grant (2019M3A9H1103651) from the National Research Foundation of Korea.

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  1. Sangjun Moon, Jihye Hong and Seokhyeong Go have equally contributed to this work.

Authors and Affiliations

  1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 08826, Republic of Korea

    Sangjun Moon & Byung-Soo Kim

  2. Interdisciplinary Program for Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea

    Jihye Hong, Seokhyeong Go & Byung-Soo Kim

  3. Institute of Chemical Processes, Institute of Engineering Research, BioMAX, Seoul National University, Seoul, 08826, Republic of Korea

    Byung-Soo Kim

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Moon, S., Hong, J., Go, S. et al. Immunomodulation for Tissue Repair and Regeneration. Tissue Eng Regen Med 20, 389–409 (2023). https://doi.org/10.1007/s13770-023-00525-0

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