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탈세포 장기 지지체의 제조 및 분석기법

Fabrication and characterization techniques for decellularized organ scaffolds

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Organ transplantation has often been successful for treatment of end-stage organ failure. However, the shortage of donor organ still remains problematic in clinical practices. As an alternative, the tissue-engineering approach for functional organ replacement has been extensively studied. More recently, decellularized organs have been emerged as a promising scaffold for reconstruction of the complicated organs (e.g., heart, liver, lung and kidney). The ideal decellularized organ scaffolds need to contain extracellular matrix (ECM), bioactive molecules, vascular systems and tissue microarchitecture. To fulfill these requirements, physical, chemical, and biological techniques have been adapted in the process of organ decellularization. In this review, the representative techniques for the organ decellularization and their characterization as well as considerations for implantation are discussed.

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Authors and Affiliations

  1. Joint Institute for Regenerative Medicine, Kyungpook National University Hospital, Daegu, 700-721, Korea

    So Young Chun, James J Yoo & Tae Gyun Kwon

  2. Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, Korea

    Se Heang Oh

  3. Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27109, USA

    James J Yoo

  4. Department of Urology, Kyungpook National University College of Medicine, Daegu, 700-842, Korea

    Tae Gyun Kwon

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  1. So Young Chun
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  2. Se Heang Oh
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  3. James J Yoo
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  4. Tae Gyun Kwon
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Correspondence to Tae Gyun Kwon.

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These authors contributed equally to this work

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Chun, S.Y., Oh, S.H., Yoo, J.J. et al. 탈세포 장기 지지체의 제조 및 분석기법. Tissue Eng Regen Med 12 (Suppl 1), 1–10 (2015). https://doi.org/10.1007/s13770-014-0421-0

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  • DOI: https://doi.org/10.1007/s13770-014-0421-0

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