Abstract
The aim of this article is to discuss the importance of staged surgeries when approaching atypical central neurocytoma in children. Also, we show the preoperative embolization of the lesion as a maneuver to reduce the intraoperative bleeding. Central neurocytomas represent less than 0.5% of all intracranial tumors, and atypical central neurocytomas usually have unfavorable outcome, with high recurrence rate. The intraventricular location is frequent, with a predilection for the lateral ventricles. When completely resected, these lesions have a good prognosis. We report a case of a 12-year old male patient that presented with a history of headache for about 6 months, which worsened for 1 week prior to admission. Magnetic resonance imaging (MRI) brain showed a massive lesion occupying both lateral ventricles. He underwent a microsurgical treatment of a highly vascularized lesion, but the perioperative bleeding required interruption of the surgery. Thus, a preoperative embolization was able to occlude most arterial feeders and allowed subtotal resection in a second surgery. The patient had complete neurological recovery despite immediate post-operative deficits, and the histopathology was suggestive of atypical neurocytoma. Two-stage surgery with preoperative adjuvant embolization is a feasible strategy for treatment of large central neurocytomas in children.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Byun J, Ho S, Min H et al (2018) Prognosis and treatment outcomes of central neurocytomas: clinical interrogation based on a single center experience. J Neurooncol. https://doi.org/10.1007/s11060-018-2997-z
Singh V, Borkar A, Moiyadi A, Shetty P (2018) Tetraventricular atypical central neurocytoma - case report. World Neurosurg. https://doi.org/10.1016/j.wneu.2018.10.233
Richardson AM, Armstrong VL, Gernsback JE, Gultekin SH, Komotar RJ (2019) Literature review central neurocytoma: rare presentation in fourth ventricle and review of literature. World Neurosurg 123:357–361. https://doi.org/10.1016/j.wneu.2018.12.021
Karthigeyan M, Gupta K, Salunke P (2017) Pediatric central neurocytoma: a short series with literature review. J Child Neurol 32(1):53–59. https://doi.org/10.1177/0883073816668994
Rades D, Schild SE, Fehlauer F (2004) Defining the best available treatment for neurocytomas in children. Internat J Am Cancer Soc 2:2629–2632. https://doi.org/10.1002/cncr.20695
Dutta SW, Kaleem TA, Muller DA et al (2018) Central neurocytoma: clinical characteristics, patterns of care, and survival. J Clin Neurosci. https://doi.org/10.1016/j.jocn.2018.04.015
Bonney PA, Boettcher LB, Iii RSK, Fung K (2015) Histology and molecular aspects of central neurocytoma. Neurosurg Clin Rev Brain Tumor Mole Path 26:21–29. https://doi.org/10.1016/j.nec.2014.09.001
Thawani JP, Lee JYK (2015) The management of residualor recurrent central neurocytoma. Neurosurg Clin NA 26(1):67–81. https://doi.org/10.1016/j.nec.2014.09.002
Hervey-Jumper SL, Berger MS (2016) Maximizing safe resection of low- and high-grade glioma. J Neurooncol 130(2):269–282
Song Y, Kang X, Cao G, Li Y, Zhou X, Tong Y (2016) Clinical characteristics and prognostic factors of brain central neurocytoma. Oncotarget 7:46
Author information
Authors and Affiliations
Contributions
All authors made substantial contributions to the conception or design of the work, the acquisition, analysis, and interpretation of data; or drafted the work or revised it critically for important intellectual content. All authors approved the version to be published, agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Corresponding author
Ethics declarations
Conflicts of interest
No conflicts by any authors.
Ethics approval
Hospital ethical committee approval.
Consent to participate
Informed consent form signed for the patient mother.
Consent for publication
Hospital ethical committee approval.
Availability of data and material
Hospital ethical committee approval.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Chaves, J.P.G., Mattozo, C.A., Telles, B.A. et al. The importance of staged surgery for giant atypical central neurocytoma. Acta Neurol Belg 121, 1715–1719 (2021). https://doi.org/10.1007/s13760-020-01480-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13760-020-01480-6