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Overview of therapeutic plasma exchange in pediatric neurology: a single-center experience

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A Correction to this article was published on 28 June 2018

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Abstract

Therapeutic plasma exchange (TPE) is used in the treatment of neurological, hematological, renal and autoimmune diseases with known or suspected immune pathogenesis. In comparison with neurological diseases of adults, knowledge about the use of TPE in children is incomplete. We report our experience on TPE in children with neurological diseases in a single institution and describe the underlying etiology, clinical course, treatment and outcome. We retrospectively evaluated 22 consecutive children (12 girls, 10 boys, aged 2–16 years) who underwent TPE in the pediatric intensive care unit between January 2010 and January 2017. There were 135 TPE procedures with median 6 TPE sessions per patient. Fresh frozen plasma was used as a replacement fluid in all cases. Most common indications were inflammatory polyneuropathy followed by acquired demyelinating diseases of the central nervous system. Other indications were autoimmune encephalitis and paraneoplastic limbic encephalitis. No mortality was recorded during TPE. The complication rate was 2.2% and consisted of transient events like hypotension and allergic reactions. Therapetic plasma exchange is one of the safe methods of treatment for neuroimmunological disorders in children, with Guillain–Barré syndrome as the most common indication.

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Change history

  • 28 June 2018

    Unfortunately, the immediate following sentences were incorrectly published in Material and Method section of the original article.

Abbreviations

TPE:

Therapeutic plasma exchange

CNS:

Central nervous system

ASFA:

American Society of Apheresis

GBS:

Guillain–Barré syndrome

CIDP:

Chronic inflammatory demyelinating polyneuropathy

IVIG:

Intravenous immunoglobulin

HFGS:

Hughes Functional Grading Score

ADS:

Acquired demyelinating syndromes

ADEM:

Acute disseminated encephalomyelitis

NMOSD:

Neuromyelitis optica spectrum disorders

CIS:

Clinically isolated syndrome

ON:

Optic neuritis

TM:

Transverse myelitis

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Acknowledgements

We thank Prof. Dr. Banu Anlar for her valuable contribution to our effort and in editing the manuscript.

Funding

The authors received no financial support for the research and/or authorship of this article.

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Authors and Affiliations

  1. Department of Pediatrics, Baskent University Faculty of Medicine, Adana Dr Turgut Noyan Teaching and Medical Research Center, Baraj Yolu 1 Durak, Seyhan, 01120, Adana, Turkey

    Murat Özkale & Yasemin Özkale

  2. Department of Pediatric Neurology, Baskent University Faculty of Medicine, Dr Turgut Noyan Teaching and Medical Research Center, Adana, Turkey

    Ilknur Erol

  3. Department of Physiology, Baskent University Faculty of Medicine, Dr Turgut Noyan Teaching and Medical Research Center, Adult Bone Marrow Transplantation Center, Apheresis Unit, Adana, Turkey

    İlknur Kozanoğlu

Authors
  1. Murat Özkale
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  2. Ilknur Erol
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  3. Yasemin Özkale
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  4. İlknur Kozanoğlu
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Contributions

MO and IE designed the study and co-wrote the manuscript. MO, İE, YO and IK were involved in patient care, including administration of medication, TPE procedures and routine clinical follow- up. MO, IE, YO, and IK collected the data. IE and Banu Anlar was involved in editing the manuscript.

Corresponding author

Correspondence to Yasemin Özkale.

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Conflict of interest

The authors declared no potential conflicts of interest with respect to the authorship and/or publication of this article.

Ethical approval

As this was a retrospective study involving data retrieved from medical records, informed patient consent was not obtained. No ethical approval was required for preparation and publication of this article.

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Özkale, M., Erol, I., Özkale, Y. et al. Overview of therapeutic plasma exchange in pediatric neurology: a single-center experience. Acta Neurol Belg 118, 451–458 (2018). https://doi.org/10.1007/s13760-018-0961-5

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  • DOI: https://doi.org/10.1007/s13760-018-0961-5

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