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A sensitive electrochemical sensor for rapid and selective determination of venlafaxine in biological fluids using carbon paste electrode modified with molecularly imprinted polymer-coated magnetite nanoparticles

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Abstract

Novel molecularly imprinted polymer-coated magnetite nanoparticles (VENMNPs) for the determination of venlafaxine (VEN) were introduced. The synthesized nanoparticles were used as a nano-modifier for carbon paste electrode. The modified electrode was used as an electrochemical sensor for electro-oxidation of venlafaxine, and subsequently for the drug sensitive and selective determination. Electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry were employed to characterize the modified carbon paste electrode. Various experimental parameters, that can potentially affect the electrochemical signal of the electro-oxidation of VEN, including pH, VENMNPs dosage, stirring time, accumulation potential and time, were optimized. The results showed that under the optimum condition, sensitive determination of venlafaxine in concentration range 0.01–10.0 μmol L−1 is achievable. The detection limit for the drug determination was obtained as 6.0 nmol L−1. Finally, the results of the drug concentration analysis in human urine and blood serum samples showed that a powerful alternative method for VEN determination in biological fluids is developed.

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References

  1. C.J. Whittington, T. Kendall, P. Fonagy, D. Cottrell, A. Cotgrove, E. Boddington, Lancet 363, 1341 (2004)

    Article  CAS  Google Scholar 

  2. L.R. Moller, J.R. Ostergaard, J. Child. Adolesc. Psychopharmacol. 19, 197 (2009)

    Article  Google Scholar 

  3. B.J. Sanghavi, A.K. Srivastava, Electrochim. Acta 56, 4188 (2011)

    Article  CAS  Google Scholar 

  4. M. Ahmadi, T. Madrakian, A. Afkhami, New J. Chem. 39, 163 (2015)

    Article  CAS  Google Scholar 

  5. M. Matoga, F. Pehourcq, K. Titier, F. Dumora, C. Jarry, J. Chromatogr. B 760, 213 (2001)

    Article  CAS  Google Scholar 

  6. R. Mandrioli, L. Mercolini, R. Cesta, S. Fanali, M. Amore, M.A. Raggi, J. Chromatogr. B 856, 88 (2007)

    Article  CAS  Google Scholar 

  7. O. Mastrogianni, G. Theodoridis, K. Spagou, D. Violante, T. Henriques, A. Pouliopoulos, K. Psaroulis, H. Tsoukali, N. Raikos, Forensic Sci. Int. 215, 105 (2012)

    Article  CAS  Google Scholar 

  8. J. Bhatt, A. Jangid, G. Venkatesh, G. Subbaiah, S. Singh, J. Chromatogr. B 829, 75 (2005)

    Article  CAS  Google Scholar 

  9. S. Rudaz, C. Stella, A.E. Balant-Gorgia, S. Fanali, J.-L. Veuthey, J. Pharm. Biomed. Anal. 23, 107 (2000)

    Article  CAS  Google Scholar 

  10. T. Madrakian, R. Haryani, M. Ahmadi, A. Afkhami, Anal. Method. 7, 428 (2015)

    Article  CAS  Google Scholar 

  11. S. Görög, Trends Anal. Chem. 26, 12 (2007)

    Article  Google Scholar 

  12. K. Sarhangzadeh, J. Iran. Chem. Soc. 1 (2015)

  13. M. Roushani, M. Sarabaegi, J. Iran. Chem. Soc. 12, 1875 (2015)

    Article  CAS  Google Scholar 

  14. G. Absalan, M. Akhond, A. Bananejad, H. Ershadifar, J. Iran. Chem. Soc. 12, 1293 (2015)

    Article  CAS  Google Scholar 

  15. D. Afzali, S. Zarei, F. Fathirad, A. Mostafavi, Mater. Sci. Eng. C 43, 97 (2014)

    Article  CAS  Google Scholar 

  16. A. Ghaffarinejad, F. Hashemi, Z. Nodehi, R. Salahandish, Bioelectrochemistry 99, 53 (2014)

    Article  CAS  Google Scholar 

  17. Y. Zhang, G.-M. Zeng, L. Tang, D.-L. Huang, X.-Y. Jiang, Y.-N. Chen, Biosens. Bioelectron. 22, 2121 (2007)

    Article  CAS  Google Scholar 

  18. Y. Zhang, G.M. Zeng, L. Tang, Y.P. Li, L.J. Chen, Y. Pang, Z. Li, C.L. Feng, G.H. Huang, Analyst 136, 4204 (2011)

    Article  CAS  Google Scholar 

  19. A. Afkhami, H. Ghaedi, T. Madrakian, M. Ahmadi, H. Mahmood-Kashani, Biosens. Bioelectron. 44, 34 (2013)

    Article  CAS  Google Scholar 

  20. A. Afkhami, F. Soltani-Felehgari, T. Madrakian, Talanta 128, 203 (2014)

    Article  CAS  Google Scholar 

  21. M. Ahmadi, T. Madrakian, A. Afkhami, Anal. Chim. Acta 852, 250 (2014)

    Article  CAS  Google Scholar 

  22. Z.-S. Liu, Y.-L. Xu, C. Yan, R.-Y. Gao, Anal. Chim. Acta 523, 243 (2004)

    Article  CAS  Google Scholar 

  23. M.C. Blanco-López, M.J. Lobo-Castañón, A.J. Miranda-Ordieres, P. Tuñón-Blanco, Trends Anal. Chem. 23, 36 (2004)

    Article  Google Scholar 

  24. S. Sadeghi, A. Motaharian, A.Z. Moghaddam, Sensor. Actuat. B 168, 336 (2012)

    Article  CAS  Google Scholar 

  25. T.H. Kim, C.D. Ki, H. Cho, T. Chang, J.Y. Chang, Macromolecules 38, 6423 (2005)

    Article  CAS  Google Scholar 

  26. S.R. Carter, S. Rimmer, Adv. Funct. Mater. 14, 553 (2004)

    Article  CAS  Google Scholar 

  27. G.-Z. Fang, J. Tan, X.-P. Yan, Anal. Chem. 77, 1734 (2005)

    Article  CAS  Google Scholar 

  28. R.L. Vu, D. Helmeste, L. Albers, C. Reist, J. Chromatogr. B 703, 195 (1997)

    Article  CAS  Google Scholar 

  29. J.L.F.C. Lima, D.V. Loo, C. Delerue-Matos, A.S. Roque da Silva, Il Farmaco 54, 145 (1999)

    Article  CAS  Google Scholar 

  30. M. Zeinoddini, K. Khajeh, F. Behzadian, S. Hosseinkhani, A.R. Saeedinia, H. Barjesteh, Photochem. Photobiol. 86, 1071 (2010)

    Article  CAS  Google Scholar 

  31. X.Y. Qin, J. Meng, X.Y. Li, J. Zhou, X.L. Sun, A.D. Wen, J. Chromatogr. B 872, 38 (2008)

    Article  CAS  Google Scholar 

  32. T. Madrakian, A. Afkhami, M.A. Zolfigol, M. Ahmadi, N. Koukabi, Nano-Micro Lett 4, 57 (2012)

    Article  CAS  Google Scholar 

  33. J.G. Waller, W.C. Wake, M.E. Dalziel, B. Atkinson, Analyst 74, 329 (1949)

    Article  Google Scholar 

  34. J.C. Abbar, S.J. Malode, S.T. Nandibewoor, Bioelectrochemistry 83, 1 (2012)

    Article  Google Scholar 

  35. V.L. Ellingrod, P.J. Perry, Am. J. Hosp. Pharm. 51, 3033 (1994)

    CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the Bu-Ali Sina University Research Council and the Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) and the authors acknowledge them for supporting this work.

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Authors and Affiliations

  1. Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

    Tayyebeh Madrakian, Reza Haryani, Mazaher Ahmadi & Abbas Afkhami

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  1. Tayyebeh Madrakian
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  2. Reza Haryani
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  3. Mazaher Ahmadi
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  4. Abbas Afkhami
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Correspondence to Tayyebeh Madrakian.

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Madrakian, T., Haryani, R., Ahmadi, M. et al. A sensitive electrochemical sensor for rapid and selective determination of venlafaxine in biological fluids using carbon paste electrode modified with molecularly imprinted polymer-coated magnetite nanoparticles. J IRAN CHEM SOC 13, 243–251 (2016). https://doi.org/10.1007/s13738-015-0731-8

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  • DOI: https://doi.org/10.1007/s13738-015-0731-8

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