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Homobimetallic complexes of ligand having O- and S-donor sites with same and different di- and trialkyl/aryltin(IV) moiety: their synthesis, spectral characterization and biological activities

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Abstract

Homobimetallic complexes with oxygen and sulphur donor ligand have been synthesized at room temperature under stirring conditions using R2SnCl2 (R = Me, n-Bu) and R3SnCl (R = Me, n-Bu, Ph) in 1:1 molar ratio. The synthesized complexes have been characterized by elemental analysis, IR and multinuclear NMR (1H, 13C) spectroscopy. These complexes have also been screened for their biological activities. IR data show that the ligand acts in a bidentate manner and exhibits trigonal bipyramidal geometry in solid state which is also confirmed by semi-empirical study. NMR data show that reported complexes exhibit tetrahedral geometry in solution. Results of antimicrobial screening activities indicated that complexes (6) and (7) are very effective antibacterial and antifungal agents, respectively, and they might indeed be a potential source of antimicrobial agents, while the complex (3) exhibits significant free radical scavenging ability with lower IC50 value of 99.47 ± 1.2 μg/mL. Results of cytotoxicity/haemolytic activity showed the significant value of % haemolysis for complex (7) (18.101 ± 2.3), while complex (4) was found to be least cytotoxic (5.733 ± 1.0). Only a few colonies are observed in mutagenicity testing by Ames test.

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Acknowledgments

S. Ali and S. Shahzadi are thankful to Quaid-i-Azam University, Islamabad and GC University, Faisalabad for support. Pakistan Science Foundation is acknowledged for partial support under the project No. PSF/Res/P-GCU/Chem(436). SKS and KQ thanks the Head, App Sci. and Dean FET, MITS for encouragement and support.

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Authors and Affiliations

  1. Department of Chemistry, GC University, Faisalabad, Pakistan

    M. Jabeen & S. Shahzadi

  2. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    S. Ali

  3. Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad, Pakistan

    M. Shahid

  4. Environmental Biotechnology Division, NIBGE, P.O. Box 577, Jhang Road, Faisalabad, Pakistan

    Q. M. Khan

  5. Department of Applied Science and Humanities, Faculty of Engineering and Technology, Mody Institute of Technology and Science (Deemed University), Lakshmangargh, District Sikar, 332311, Rajasthan, India

    S. K. Sharma & K. Qanungo

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  1. M. Jabeen
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Correspondence to S. Ali or S. Shahzadi.

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Jabeen, M., Ali, S., Shahzadi, S. et al. Homobimetallic complexes of ligand having O- and S-donor sites with same and different di- and trialkyl/aryltin(IV) moiety: their synthesis, spectral characterization and biological activities. J IRAN CHEM SOC 9, 307–320 (2012). https://doi.org/10.1007/s13738-011-0025-8

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