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A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil

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Abstract

Severe hepatotoxicity from combination chemotherapy with cisplatin and 5-fluorouracil is a rare adverse effect. In this case report, we present a case with severe hepatotoxicity immediately following chemotherapy with cisplatin and 5-fluorouracil. This female patient had previously been treated with this combination with no hepatotoxicity. The elevated liver enzymes quickly normalized after chemotherapy was stopped. There were no specific changes in liver imaging. As hepatotoxicity occurred after repeated administration of cisplatin, we suggest that this hepatotoxicity might represent a case of allergic hepatitis caused by cisplatin. Severe hepatotoxicity should be watched for with repeated administration of cisplatin.

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Authors and Affiliations

  1. Department of Pharmacy, Niigata University Medical and Dental Hospital, 754-banchi, Asahimati-dori 1-bancho, Chuo-ku, Niigata, 951-8520, Japan

    Ayaka Yaegashi, Kensuke Yoshida, Naoto Suzuki, Izumi Shimada & Akira Toyama

  2. Department of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

    Yusuke Tani

  3. Department of Medical Oncology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

    Yasuo Saijo

Authors
  1. Ayaka Yaegashi
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  2. Kensuke Yoshida
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  3. Naoto Suzuki
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  4. Izumi Shimada
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  5. Yusuke Tani
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  6. Yasuo Saijo
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  7. Akira Toyama
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Correspondence to Ayaka Yaegashi.

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Yaegashi, A., Yoshida, K., Suzuki, N. et al. A case of severe hepatotoxicity induced by cisplatin and 5-fluorouracil. Int Canc Conf J 9, 24–27 (2020). https://doi.org/10.1007/s13691-019-00394-2

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  • DOI: https://doi.org/10.1007/s13691-019-00394-2

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