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The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review

  • Metabolism (P Trayhurn, Section Editor)
  • Published:
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Abstract

Recent research suggests a mechanistic role for bile acids (BA) in the metabolic improvement following bariatric surgery. It is believed that the hormonal and metabolic effects associated with changes in systemic BAs may be related to the farnesoid X receptor (FXR) and a G-protein coupled receptor (TGR5). This systematic review examines changes in systemic BAs following bariatric procedures. Studies were included if they reported the measurement of systemic BAs in humans at at least one time point after bariatric surgery. Eleven papers were identified that met the inclusion criteria. Seven studies reported the effect of Roux-en-Y gastric bypass (RYGB) on fasting BAs. The majority (6/7) reported that fasting BAs increased after RYGB. Data regarding fasting BAs after vertical sleeve gastrectomy (VSG) and laparoscopic gastric banding (LAGB) are inconsistent. Data regarding post-prandial BA changes after RYGB, VSG, and LAGB are also inconsistent. More research is needed to investigate the connection between BAs and the metabolic improvement seen after bariatric surgery.

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Acknowledgments

Abigail Cole and Levi Teigen contributed equally to this work under the joint guidance of Shalamar Sibley and Carrie Earthman.

Compliance with Ethics Guidelines

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Conflict of Interest

Abigail J. Cole, Levi M. Teigen, Cyrus Jahansouz, Carrie P. Earthman, and Shalamar D. Sibley declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Author information

Authors and Affiliations

  1. Department of Food Science and Nutrition, University of Minnesota-Twin Cities, 1334 Eckles Avenue, Saint Paul, MN, 55108, USA

    Abigail J. Cole, Levi M. Teigen & Carrie P. Earthman

  2. Medical School, Department of Surgery, University of Minnesota-Twin Cities, 420 Delaware Street SE, Minneapolis, MN, 55404, USA

    Cyrus Jahansouz

  3. Department of Medicine, Division of Endocrinology, University of Minnesota-Twin Cities, 516 Delaware St. SE, Minneapolis, MN, 55455, USA

    Shalamar D. Sibley

Authors
  1. Abigail J. Cole
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  2. Levi M. Teigen
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  3. Cyrus Jahansouz
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Correspondence to Carrie P. Earthman.

Additional information

This article is part of the Topical Collection on Metabolism

Appendix 1. EMBASE Search Conducted 2/19/2015

Appendix 1. EMBASE Search Conducted 2/19/2015

  1. 1

    exp bile acid/ (47257)

  2. 2

    bile acid*.mp. (32762)

  3. 3

    1 or 2 (54345)

  4. 4

    exp stomach bypass/ (11635)

  5. 5

    gastric bypass.mp. (10950)

  6. 6

    exp bariatric surgery/ (20128)

  7. 7

    bariatric surgery.mp. (18667)

  8. 8

    weight loss surgery.mp. (733)

  9. 9

    exp roux y anastomosis/ (6784)

  10. 10

    roux-en-y.mp. (10066)

  11. 11

    exp gastric sleeve/ (209)

  12. 12

    gastric sleeve.mp. (372)

  13. 13

    exp sleeve gastrectomy/ (3797)

  14. 14

    sleeve gastrectomy.mp. (4643)

  15. 15

    metabolic surgery.mp. (533)

  16. 16

    4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 (33371)

  17. 17

    3 and 16 (497)

  18. 18

    limit 17 to (human and (adult <18 to 64 years > or aged <65+ years>)) (75)

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Cole, A.J., Teigen, L.M., Jahansouz, C. et al. The Influence of Bariatric Surgery on Serum Bile Acids in Humans and Potential Metabolic and Hormonal Implications: a Systematic Review. Curr Obes Rep 4, 441–450 (2015). https://doi.org/10.1007/s13679-015-0171-x

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