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Ginseng: a miracle sources of herbal and pharmacological uses

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Abstract

This review paper was considered to find out the relationship, how to bring together traditional uses and modern pharmacological uses and provide a foundation for a more rigorous systemic investigation of ginseng. Ginseng is well-known worldwide as a medicinal plant. Its traditional and modern medicinal applications have been well documented. This medicinal plant is of great value to the people of Korea, China, and Japan and has been used for many purposes. Though all the parts of these plants have medicinal value, the roots are used most extensively in traditional medicine, especially for its curative and restorative properties. Ginseng is used to treat a variety of illnesses in traditional medicine. It is most effective for impotence, insomnia, anorexia, hypodynamia, diabetes, palpitation, shortness of breath, and hemorrhage. From a modern medical point of view, ginseng possesses a variety of constituents, including ginsenosides, polysaccharides, peptides, and polyacetylenic alcohols that have been used effectively for the central nervous system,neuroprotective, immunomodulatory, and anticancer effects. In particular, ginsenosides as an active ingredient have antioxidant, anti-inflammatory, antiapoptotic, and immunostimulant properties. The understanding of ginseng efficacy from Traditional Korean Medicine (TKM) and Traditional Chinese Medicine (TCM) can provide insights for modern chemical and pharmacological research. Such research will help clarify the pharmacodynamics and mechanisms of action of ginseng.

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References

  • Abdel-Wahhab MA, Hassan NS, El-Kady AA (2010) Red ginseng extract protects against aflatoxin B1 and fumonisins induced hepatic pre-cancerous lesions in rats. Food ChemToxicol 48:733–742

    Article  CAS  Google Scholar 

  • Abdel-Wahhab MA, El-Nekeety AA, Aly SE, Yoon WJ, Kim YT, Park MH (2013) Improvement of sexual behavior in male rats via dietary supplementation with Panax ginseng extract standardized with ginsenoside Rg3. J Med Sci 13:337–345

    Article  CAS  Google Scholar 

  • Abdel-Wahhab MA, El-Kady AA, Joubert O, El-Nekeety AA, Kim YT, Yoon WJ, Park MH, Rihn BH (2014) Pharmacological effect of Panax ginseng extract standardized with ginsenoside Rg3 on mating behavior of male rats treated with dopamine antagonists. British J Pharmaceut Res 4:1228–1241

    Article  CAS  Google Scholar 

  • Ang-Lee MK, Moss J, Yuan CS (2001) Herbal medicines and perioperative care. J Am Med Assoc 286:208–216

    Article  CAS  Google Scholar 

  • Attele AS, Wu JA, Yuan CS (1999) Ginseng pharmacology:multiple constituents and multiple actions. BiochemPharmacol 58:1685–1693

    CAS  Google Scholar 

  • Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS (2002) Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51:1851–1858

    Article  CAS  PubMed  Google Scholar 

  • Back NI, Kim DS, Lee YH, Park JD, Lee CB, Kim SI (1996) Ginsenoside Rh4, a genuine dammarane glycoside from korean red ginseng. PlantaMedica 62:86–87

    Google Scholar 

  • Baeg IH, Seung HS (2013)The world ginseng market and the ginseng. J Ginseng Res37: 1–7.

  • Bak MJ, Jun M, Jeong WS (2012) Antioxidant and hepatoprotective of the red ginseng essential oil in H2O2-treated HepG2 cells and CCl4-treated mice. 2012. IntJ MolSci 13:2314–2330

    CAS  Google Scholar 

  • Bensky D, Barolet R (1990) Chinese herbal medicine: Formulas and Strategies, rev. ed. Eastland Press, Seattle: WA.

  • Brekhman II (1965) Eleutherococcussenticosus-a new medicinal herb of the Araliaceae family. In: Pharmacology of Oriental Plants. Proc. 2nd Int. Pharmacol. Meet. Oxford: Pergamon Press 7:97–101

    Google Scholar 

  • Broadhurst CL, Polansky MM, Anderson RA (2000) Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 48:849–852

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Yang SJ, Chen L, Ma XL, Chen YP, Wang LL, Sun CW (1994) The effects of Panaxquinquefoliumsaponin (PQS) and its monomer ginsenoside on heart. ZhongguoZhong Yao ZaZhi 19:617–620

    CAS  Google Scholar 

  • Chen F, Eckman EA, Eckman CB (2006) Reductions in levels of the Alzheimer’s amyloid beta peptide after oral administration of ginsenosides. FASEB J 20:1269–1271

    Article  CAS  PubMed  Google Scholar 

  • Chevallier A (2000) Encyclopedia of herbal medicine. New York: DK Publishing Inc

  • Christensen LP, Steve LT (2008) Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects. Academic Press p:1–99

  • Cui J, Garle M, Eneroth P, Bjorkhem I (1994) What do commercial ginsengpreparationscontain? Lancet 344:134

    Article  CAS  PubMed  Google Scholar 

  • Cui X, Sakaguchi T, Shirai Y, Hatakeyama K (1999) Orally administered Panax ginseng extract decreases platelet adhesiveness in 66 % hepatectomized rats. Am J Chin Med 27:251–256

    Article  CAS  PubMed  Google Scholar 

  • Dey L, Zhang L, Yuan CS (2002) Anti-diabetic and anti-obese effects of ginseng berry extract: comparison between intraperitoneal and oral administrations. Am J Chin Med 30:645–647

    Article  PubMed  Google Scholar 

  • Deyama TN, Najazawa Y (2001) Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin 22:1057–1070

    CAS  PubMed  Google Scholar 

  • Dou DQ, Chen YJ, Liang LH, Pang FG, Shimizu N, Takeda T (2001) Six new dammarane type triterpenesaponins from the leaves of Panax ginseng. Chem Pharm Bull 49:442–446

    Article  CAS  PubMed  Google Scholar 

  • Evans BI (1985) Ginseng: root of Chinese-Canadian relations. Can Hist Rev 66:1–26

    Article  Google Scholar 

  • Fleming T (1998) Physician desk references for herbal medicine. Medical Economics Company: New Jersey, 1101

  • Goldstein B (1975) Ginseng: its history, dispersion, and folk tradition. Am J Chin Med 3:223–234

    Article  CAS  PubMed  Google Scholar 

  • Guan L, Yi X, Feng Q, Yang L (1996) Effects of saponins from stems and leaves of PanaxquinquefoliumL. on the contraction of rabbit aortic strips. Zhongguo Zhong yao za Zhi 20:431–434

    Google Scholar 

  • Harding AR (1913) Ginseng and other medicinal plants. Columbus, Ohio:a.R. Harding Publishing Co. p. 43

  • Hasegawa H, Matsumiya S, Uchiyama M (1994) Inhibitory effect of some triterpenoidsaponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med 60:240–243

    Article  CAS  PubMed  Google Scholar 

  • Hong M (1991) Effects of ageing and ginsenoside on atrial natriuretic peptide gene expression. Zhonghua Yi Xue Za Zhi 71:140–143

    CAS  PubMed  Google Scholar 

  • Hong M, Jin Y, Mai YQ, Boersma A, Han KK, Vantyghem MC, Lefebere J (1992) The decline of atrial natriuretic peptide (ANP) gene expression in older rats and the effects of ginsenoside on ANP gene expression. Comp BiochemPhysiol 101:35–39

    CAS  Google Scholar 

  • Hu SY (1977) A contribution to our knowledge of ginseng. Am J Chin Med 5:1–23

    Article  CAS  PubMed  Google Scholar 

  • Iishi H, Tatsuta M, Baba M, Uehara H, Nakaizumi A, Shinkai K, Akedo H, Funai H, Ishiguro S, Kitagawa I (1997) Inhibition by ginsenoside Rg3 of bombesin-enhanced peritoneal metastasis of intestinal adenocarcinomas induced by azoxymethane in Wistar rats. ClinExpMetast 15:603–611

    CAS  Google Scholar 

  • Jiang Y, Zhong GG, Chen L, Ma XY (1992) Influences of ginsenosides Rb1, Rb2, and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes. Zhongguo Yao Li XueBao 13:403–406

    CAS  Google Scholar 

  • Jung CHS, Choi IW, Cho HY (2005a) Antioxidant activities of cultivated and wild Korean ginseng leaves. Food Chem 92:535–540

    Article  CAS  Google Scholar 

  • Jung CH, Seog HM, Choi IW, Choi HD, Cho HY (2005b) Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J Ethnopharmacol 98:245–250

    Article  PubMed  Google Scholar 

  • Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA (2002) Recent patterns of medication use in the ambulatory adult population of the United States. J Am Med Assoc 287:337–344

    Article  Google Scholar 

  • Kee CH (1999) The pharmacology of Chinese herbs (2nddition), herbs with multiple actions ginseng;CRC press. York, New

    Google Scholar 

  • Kim S (2007) Ginseng and border trespassing between Qing China andChoson Korea. Late Imperial China 28:33–61

    Article  Google Scholar 

  • Kim YK, Guo Q, Packer L (2002) Freeredical scavenging activity of red ginseng aqueous extracts. Toxicol 172: 149–156

  • Kim YS, Kim YH, Noh JR, Cho ES, Park JH, Son HY (2011a) Protective effect of korean red ginseng against aflatoxin B1-induced hepatotoxicityin rat. J Ginseng Res 35:243–249

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim HG, Yoo SR, Park HJ (2011b) Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial. Food ChemToxicol 49:2229–2235

    Article  CAS  Google Scholar 

  • Kim TS, Kim YJ, Jang SA, Yang KH, Seung NK, Sohn EH (2012) Protective effects of red ginseng against radiation induced hepatotoxicity in mice,” in Proceedings of the Spring International Ginseng Conference, p. 100, The Korean Society of Ginseng, Jeju, Korea

  • Kitts DD, Wijewickreme AN, Hu C (2000) Antioxidant properties of a north American ginseng extract. Mol Cell Biochem 203:1–10

    Article  CAS  PubMed  Google Scholar 

  • Kitts DD, Popovich DG, Hu C (2007) Characterizing the mechanism for ginsenoside induced cytotoxicity in cultured leukemia (THP-1) cells. Can J PhysiolPharmacol 85:1173–1183

    Article  CAS  Google Scholar 

  • Korea Ginseng & Tobacco Research Institute. (1986) An Introduction to Korean Ginseng: The Elixir of Life. 3rd ed. 134 Daejeon, Korea

  • Kubo M, Tong CN, Matsuda H (1992) Influence of 70 % methanol extract from red ginseng on the lysosome of tumor cells and on the cytocidal effect of mitomycin C. Planta Med 58:424–428

    Article  Google Scholar 

  • Li TSC, Mazza G, Cottrell AC, Gao L (1996) Ginsenosides in roots and leaves of American ginseng. J Agric Food Chem 44:717–720

    Article  CAS  Google Scholar 

  • Li J, Huang M, Teoh H, Man RY (1999) Panax quinquefolium saponins protects low density lipoproteins from oxidation. Life Sci 64:53–62

    Article  CAS  PubMed  Google Scholar 

  • Liberti LE, Der Marderosian A (1978) Evaluation of commercial ginseng products. J Pharm Sci 10:1487–1489

    Article  Google Scholar 

  • Liu CX, Xiao PG (1992) Recent advances in ginseng research in China. J Ethnopharmacol 36:27–38

    Article  CAS  PubMed  Google Scholar 

  • Lu JM, Yao Q, Chen C (2009) Ginseng compounds: an update on their molecular mechanisms and medical applications. CurrVascPharmacol 7:293–302

    CAS  Google Scholar 

  • Ming O (1989) Chinese-English manual of common-used herbs in traditional Chinese medicine, Joint Publishing Co., Hong Kong

  • Molokovskii DS, Davydov VV, Tiulenev VV (1989) The action of adaptogenic plant preparations in experimental alloxan diabetes. Probl Endokrinol (Mosk) 35:82–87

    CAS  Google Scholar 

  • Murphy LL, Lee TJ (2002) Ginseng, sex behavior and nitric oxide. Ann NY AcadSci 62:372–377

    Article  Google Scholar 

  • Nguyen MD, Nguyen TN, Kasai R, Ito A, Yamasaki K, Tanaka O (1993) Saponins from Vietnamese ginseng, Panaxvietnamensis Ha et Grushv. Collected in Central Vietnam. 1. Chem Pharm Bull 41:2010–2014

    Article  CAS  PubMed  Google Scholar 

  • Onomura M, Tsukada H, Fukuda (1999) Effects of ginseng radix on sugar absorption in the small intestine. Am J Chin Med 27:347–354

    Article  CAS  PubMed  Google Scholar 

  • Oxford Dictionaries Online, s.v. “ginseng”. https://en.oxforddictionaries.com/definition/ginseng

  • Park H (2003) The history of ginseng cultivation in the orient. ActaHortic 620: 453–460

  • Park HSKT, Moon DG, Kim JJ, Cheon J (2004) Development of the novel anti-cancer immunotherapy for human prostate cancer: in vivo characterization of an immunotropic and anti-cancer activities of the new polysaccharide from the leaves of Panax ginseng C.A. Meyer EurUrolSuppl 3:365–366

    Google Scholar 

  • Park HM, Go HK, Mun AR (2012). Red ginseng attenuate an ethanol-induced hepatocyte toxicity, by increasing the level of Mg2+ and suppression of the MAPK pathway,” in Proceedings of the Spring International Ginseng Conference, p. 93, The Korean Society of Ginseng, Jeju, Korea

  • Phillipson JD, Anderson LA (1984) Ginseng-quality safety and efficacy? Pharm J 232:161–165

    CAS  Google Scholar 

  • Quan HY, Yuan HD, Jung MS, Ko SK, Park YG, Chung SH (2012) Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP- activated protein kinase in HepG2 cells and high-fat diet fed mice. Int JMol Med 29:73–80

    CAS  Google Scholar 

  • Saito H, Morita M, Takagi K (1973) Pharmacological studies of Panax ginseng leaves. JpnJ Pharmacol 23:43–56

    Article  CAS  Google Scholar 

  • Shi L, Fan PS, Wu L (1990) Effects of total saponins of Panaxnotoginseng on increasing PGI2 in carotid artery and decreasing TXA2 in blood platelets. Zhongguo Yao Li XueBao 11:29–32

    CAS  Google Scholar 

  • Shinkai K, Akedo H, Mukai M, Imamura F, Isoai A, Kobayashi M, Kitagawa I (1996) Inhibition of in vitro tumor cell invasion by ginsenoside Rg3. Jpn J Cancer Res 87:357–362

    Article  CAS  PubMed  Google Scholar 

  • Song CSR, Shi Y, Song J, Tian J, Guo JZ, Dai X, Yang JD (2006) Effect of qutanhuoluojiannao preparation in improving memory impairment of rats with cerebral ischemia. Chin J ClinRehabil 10:32–35

    Google Scholar 

  • Sui DY, Yu XF, Qu SC, Lu ZZ, Wang L, Chen MQ (2001) Protective effect of Panaxquinquefolium 20s-proto-panaxdiolsaponins on acute myocardial infarction in dogs. ZhongguoZhong Yao ZaZhi 26:416–419

    CAS  Google Scholar 

  • Tang W, Eisenbrand G (1992) Chinese drugs of plant origin; Springer-Verlag: Berlin. p. 711–37

  • Tyler VE (1993) The honest herbal – a sensible guide to the use of herbs and related remedies. Haworth Press, New York, p. 149

    Google Scholar 

  • Vuksan V, Sievenpiper JL, Xu Z (2001) Konjac-Mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitus. J Am CollNutr 20(Suppl. 5):370S–380S

    CAS  Google Scholar 

  • Wakabayashi C, Hasegawa H, Murata J, Saiki I (1997) In vivo antimetastatic action of ginsengprotopanaxadiolsaponins is based on their intestinal bacterial metabolism after oral administration. Oncol Res 9:411–417

    CAS  PubMed  Google Scholar 

  • Wang J (1987) The earliest officially published pharmacopoeia in the world. J TraditChin Med 7:155–156

    CAS  Google Scholar 

  • Wang BX, Cui JC, Liu AJ (1982) The action of ginsenosides extracted from the stems and leaves of Panax ginseng in promoting animal growth. Yao XueXueBao 17: 899–904 (in Chinese)

  • Wang CL, Shi DZ, Yin HJ (2007) Effect of Panaxquinquefoliussaponin on angiogenesis and expressions of VEGF and bFGF in myocardium of rats with acute myocardial infarction. ZhongguoZhong Xi Yi Jie He ZaZhi 27:331–334

    CAS  Google Scholar 

  • Wang X, Chu S, Qian T, Chen J, Zhang J (2010) Ginsenoside Rg1 improves male copulatory behavior via nitric oxide/cyclic guanosine mono phosphate pathway. J Sexual Med 7:743–750

    Article  CAS  Google Scholar 

  • Wen J, Zimmer EA (1996) Phylogeny and biogeography of Panax L. (the Ginseng genus, Araliaceae): Inferences from ITS sequenes of nuclear ribosomal DNA. Mol Phylogenet Evol 6:167–177

    Article  CAS  PubMed  Google Scholar 

  • Widodo N, Takagi Y, Shrestha BG, Ishii T, Kaul SC, Wadhwa R (2008) Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett 262:37–47

    Article  CAS  PubMed  Google Scholar 

  • Xie JT, Aung HH, Wu JA, Attele AS, Yuan CS (2002) Effects of American ginseng berry extract on blood glucose levels in ob/obmice. Am J Chin Med 30:187–194

    Article  PubMed  Google Scholar 

  • Xie JT, Mehendale SR, Wang A, Aung HH, Wu J, Osinski J, CS Y (2004) American ginseng leaf: ginsenoside analysis and hypoglycemic activity. Pharmacol Res 49:113–117

    Article  CAS  PubMed  Google Scholar 

  • Xie JT, Attele AS, Yuan CS (2006) Ginseng: beneficial and potential adverse effect. In: Yuan CS, Beiber E, Bauer BA (eds) A textbook of complementary and alternative therapies. CRC Press Company, Boca Raton, London, New York, Washington, DC, pp. 71–89

    Google Scholar 

  • Yang JP, Yeo IS (2004) A study on the origins of ‘Korean ginseng. Korean J Med Hist 13:1–19

    Google Scholar 

  • Yang WM, Park SY, Kim HM, Park EH, Park SK, Chang MS (2011) Effects of Panax ginseng on glial cell derived neurotrophic factor (GDNF) expression and spermatogenesis in rats. Phytother Res 25:308–311

    PubMed  Google Scholar 

  • Yun TK (1996) Experimental and epidemiologic evidence of cancer preventive effects of Panax ginseng C.A. Meyer. Nutr Rev 54:S71–S81

    Article  CAS  PubMed  Google Scholar 

  • Zhang QH, Wu CF, Duan L, Yang JY (2008) Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food ChemToxicol 46:293–302

    Article  Google Scholar 

  • Zheng BC (1985) Shennong’s herbal - one of the world’s earliest pharmacopoeia. J Tradit Chin Med 5:236

    CAS  PubMed  Google Scholar 

  • Zhou L, Hao R, Jiang L (1999) Clinical study on retarding aging effect of tongbu recipe to traditional Chinese medicine. Zhongguo Zhong Xi Yi Jie He Za Zhi 19:218–220

    CAS  PubMed  Google Scholar 

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Kim, J.K., Tabassum, N., Uddin, M.R. et al. Ginseng: a miracle sources of herbal and pharmacological uses. Orient Pharm Exp Med 16, 243–250 (2016). https://doi.org/10.1007/s13596-016-0246-6

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