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Pathologic factors of brain edema in acute ischemic stroke research

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Abstract

Ischemic stroke is a principal disease lead to death or leave behind the physical and psychological sequel. Stroke patients are increasing every year world widely. In Korea, large portion of stroke patients prefer to rely on the therapy of Korean medicine. Several transcriptions including Woohwangchungsim Won and Sohaphwang Won have been used to treat the acute stroke patients. However, it is currently difficult to have chances to treat patients. It might be partially come from the lack of scientific or statistical analysis of data of the cases. Thus, it is necessary to demonstrate the pharmacological activities on acute stage of stroke, to accumulate the case data and to analyze via basic and clinical studies. We initiated the current review with our opinions, the prescriptions used in acute stroke might be closely related to or useful in treatment of brain edema followed by the elevation of intracranial pressure (ICP), Because the symptoms in ICP elevation in acute stroke may be correlated to the indications of the prescriptions. Vasogenic edema, a major deleterious type of brain edema occurs in acute phase of stroke and persists for several days. It is known to be caused by the factors related to Blood brain barrier damage which are extensively studied. The purpose of the current study was to suggest several targets to the studies using prescriptions for acute stroke in traditional Korean Medicine.

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Acknowledgment

This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2012R1A1A2008587)

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The authors declare no conflict of interest.

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  1. College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 130-701, Republic of Korea

    Kyungjin Lee, Jae-Woo Park, Bumjun Lee & Youngmin Bu

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  1. Kyungjin Lee
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Correspondence to Youngmin Bu.

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Lee, K., Park, JW., Lee, B. et al. Pathologic factors of brain edema in acute ischemic stroke research. Orient Pharm Exp Med 15, 1–5 (2015). https://doi.org/10.1007/s13596-014-0159-1

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