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Elastography for portable ultrasound

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Abstract

Portable wireless ultrasound has been emerging as a new ultrasound device due to its unique advantages including small size, lightweight, wireless connectivity and affordability. Modern portable ultrasound devices can offer high quality sonogram images and even multiple ultrasound modes such as color Doppler, echocardiography, and endovaginal examination. However, none of them can provide elastography function yet due to the limitations in computational performance and data transfer speed of wireless communication. Also phase-based strain estimator (PSE) that is commonly used for conventional elastography cannot be adopted for portable ultrasound, because ultrasound parameters such as data dumping interval are varied significantly in the practice of portable ultrasound. Therefore, this research aims to propose a new elastography method suitable for portable ultrasound, called the robust phase-based strain estimator (RPSE), which is not only robust to the variation of ultrasound parameters but also computationally effective. Performance and suitability of RPSE were compared with other strain estimators including time-delay, displacement-gradient and phase-based strain estimators (TSE, DSE and PSE, respectively). Three types of raw RF data sets were used for validation tests: two numerical phantom data sets modeled by an open ultrasonic simulation code (Field II) and a commercial FEA (Abaqus), and the one experimentally acquired with a portable ultrasound device from a gelatin phantom. To assess image quality of elastograms, signal-to-noise (SNRe) and contrast-to-noise (CNRe) ratios were measured on the elastograms produced by each strain estimator. The computational efficiency was also estimated and compared. Results from the numerical phantom experiment showed that RPSE could achieve highest values of SNRe and CNRe (around 5.22 and 47.62 dB) among all strain estimators tested, and almost 10 times higher computational efficiency than TSE and DSE (around 0.06 vs. 5.76 s per frame for RPSE and TSE, respectively).

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References

  1. Ophir J, Cespedes I, Ponnekanti H, et al. Elastography: a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13(2):111–34.

    Article  Google Scholar 

  2. Ophir J, Srinivasan S, Righetti R, et al. Elastography: a decede of progress (2000–2010). Curr Med Imaging Rev. 2011;7(4):292–312.

    Article  Google Scholar 

  3. Ophir J, Alam SK, Garra BS, et al. Elastography: imaging the elastic properties of soft tissues with ultrasound. J Med Ultrason. 2002;29(4):155–71.

    Article  Google Scholar 

  4. Skovoroda AR, Klishko AN, Gusakyan DA, et al. Quantitative analysis of the mechanical characteristics of pathologically changed soft biological tissues. Biophysics. 1995;40(6):1359–64.

    Google Scholar 

  5. Han Y, Kim DW, Kwon HJ. Application of digital image cross-correlation and smoothing function to the diagnosis of breast cancer. J Mech Behav Biomed Mater. 2012;14:7–18.

    Article  Google Scholar 

  6. Shin B, Gopaul D, Fienberg S, Kwon HJ. Application of Eshelby’s solution to elastography for diagnosis of breast cancer. Ultrason Imaging. 2016;38(2):115–36.

    Article  Google Scholar 

  7. Lorenz A, Sommerfeld H-J, Garcia-Schürmann M, et al. A new system for the acquisition of ultrasonic multicompression strain images of the human prostate in vivo. IEEE Trans Ultrason Ferroelectr Freq Control. 1999;46(5):1147–54.

    Article  Google Scholar 

  8. Rivaz H, Fleming I, Assumpcao L, et al. Ablation monitoring with elastography: 2D in vivo and 3D ex vivo studies. In: Medical image computing computer-assisted intervention—MICCAI, Berlin Heidelberg, Germany, 6 Sep 2008, pp 458–66.

  9. Chernak LA, Thelen DG. Tendon motion and strain patterns evaluated with two-dimensional ultrasound elastography. J Biomech. 2012;45(15):2618–23.

    Article  Google Scholar 

  10. Brandenburg JE, Eby SF, Song P, et al. Ultrasound elastography: the new frontier in direct measurement of muscle stiffness. Arch Phys Med Rehabil. 2014;95(11):2207–19.

    Article  Google Scholar 

  11. Muraki T, Ishikawa H, Morise S, Yamamoto N, et al. Ultrasound elastography-based assessment of the elasticity of the supraspinatus muscle and tendon during muscle contraction. J Shoulder Elb Surg. 2015;24(1):120–6.

    Article  Google Scholar 

  12. Nelson BP, Sanghvi A. Out of hospital point of care ultrasound: current use models and future directions. Eur J Trauma Emerg Surg. 2016;42(2):139–50.

    Article  Google Scholar 

  13. Heimdal A, Støylen A, Torp H, Skjærpe T. Real-time strain rate imaging of the left ventricle by ultrasound. J Am Soc Echocardiogr. 1998;11(11):1013–9.

    Article  Google Scholar 

  14. Børstad TK. Intraoperative ultrasound strain imaging of brain tumors. Master Thesis, Norwegian University of Science and Technology, Norway, 2011.

  15. Barber WD, Eberhard JW, Karr SG. A new time domain technique for velocity measurements using Doppler ultrasound. IEEE Trans Biomed Eng. 1985;3:213–29.

    Article  Google Scholar 

  16. David J-Y, Jones SA. Modern spectral analysis techniques for blood flow velocity and spectral measurements with pulsed Doppler ultrasound. IEEE Trans Biomed Eng. 1991;38(6):589–96.

    Article  Google Scholar 

  17. Wilson LS. Description of broad-band pulsed Doppler ultrasound processing using the two-dimensional Fourier transform. Ultrason Imaging. 1991;13(4):301–5.

    Article  Google Scholar 

  18. Loupas T, Powers JT, Gill RW. An axial velocity estimator for ultrasound blood flow imaging, based on a full evaluation of the dropper equation by means of a two-dimensional autocorrelation approach. IEEE Trans Ultrason Ferroelectr Freq Control. 1995;42(4):672–88.

    Article  Google Scholar 

  19. Jensen JA, Svendsen NB. Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers. IEEE Trans Ultrason Ferroelectr Freq Control. 1992;39(2):262–7.

    Article  Google Scholar 

  20. Jensen JA. Field: A program for simulating ultrasound systems. In: 10th Nordic-Baltic conference on biomed imaging. 1996, vol. 34, suppl. 1, part 1, p. 351–3.

  21. Madsen EL, Zagzebski JA, Frank GR. An anthropomorphic ultrasound breast phantom containing intermediate-sized scatterers. Ultrason Med Biol. 1982;8:381–92.

    Article  Google Scholar 

  22. Chaturvedi P, Insana MF, Hall TJ. 2-D companding for noise reduction in strain imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 1998;45(1):179–91.

    Article  Google Scholar 

  23. Céspedes I, Ophir J. Reduction of image noise in elastography. Ultrason Imaging. 1993;15(2):89–102.

    Article  Google Scholar 

  24. Ophir J, Alam SK, Garra B, Varghese T. Elastography: ultrasonic estimation and imaging of the elastic properties of tissues. Proc Inst Mech Eng Part H J Eng Med. 1999;213(3):203–33.

    Article  Google Scholar 

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Acknowledgements

The work was supported by Natural Sciences and Engineering Research Council of Canada (NSERC).

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Correspondence to Bonghun Shin.

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Bonghun Shin, Soo Jeon, Jeongwon Ryu, and Hyock Ju Kwon declare that they have no conflict of interest in relation to the work in this article.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Shin, B., Jeon, S., Ryu, J. et al. Elastography for portable ultrasound. Biomed. Eng. Lett. 8, 101–116 (2018). https://doi.org/10.1007/s13534-017-0052-1

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