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Heart rate variability and vibration perception threshold in type 2 diabetes mellitus

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Abstract

The aim of the study was to compare heart rate variability (HRV) and vibration perception threshold (VPT) of patients with type 2 diabetes mellitus (T2DM) with control. The study was conducted on 60 patients with T2DM and 30 controls. The short term HRV and VPT were assessed in the both groups. All the time domain measures, SDNN [26 (15.5–35) vs 36 (30–40.25) ms, P = 0.002], RMSSD [25.9 (11.95–40.45) vs 36.65 (27.05–44.13) ms, P = 0.002], and pNN50 [3.5 (0.23–21.83) vs 16.4 (4.45–27.63) %, P = 0.002] were less in T2DM. Similarly, in frequency domain, low frequency (LF) power [81 (32–148.75) vs 126 (85.25–237.75) ms2, P = 0.007], high frequency (HF) power [81 (16.75–187.75) vs 182.5 (121.50–281.75) ms2, P = 0.001] and HF nu [54.5 (33.2–63.83) vs 59.7 (50–75.05), P = 0.03] were significantly less in T2DM. Whereas, LF nu [45.25 (35.28–63.93) vs 44.65 (33.7–65.35)] and LF/HF ratio [0.78 (0.54–1.13) vs 0.7 (0.4–1)] were comparable between the groups. In Poincare plot, SD1 [18.5 (8.73–28.98) vs 26.2 (19.33–31.65) ms, P = 0.003] and SD2 [37 (26.13–51.18) vs 48.6 (39.63–56.15) ms, P = 0.016] as well as the ratio of SD1/SD2 [0.18 (0.14–0.21) vs 0.29 (0.25–0.33) P = 0.001] were less in T2DM. However, VPT was comparable between the groups. The patients with T2DM had reduced parasympathetic activity whereas sympathetic activity and vibration (somatic) sensation were similar. It indicates that cardiac parasympathetic activity in T2DM is affected before sympathetic and somatic activity.

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Authors and Affiliations

  1. Department of Physiology, Nepalgunj Medical College, Nepalgunj, Nepal

    Rajesh Kumar Goit

  2. Department of Physiology, B P Koirala Institute of Health Sciences, Dharan, Nepal

    Bishnu Hari Paudel & Rita Khadka

  3. Department of Internal Medicine, B P Koirala Institute of Health Sciences, Dharan, Nepal

    Sanjib Kumar Sharma

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  1. Rajesh Kumar Goit
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  2. Bishnu Hari Paudel
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  3. Sanjib Kumar Sharma
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  4. Rita Khadka
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Correspondence to Rajesh Kumar Goit.

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Goit, R.K., Paudel, B.H., Sharma, S.K. et al. Heart rate variability and vibration perception threshold in type 2 diabetes mellitus. Int J Diabetes Dev Ctries 33, 134–139 (2013). https://doi.org/10.1007/s13410-013-0121-7

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