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Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen

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Abstract

The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95 % CI) of PN and SPN were 31 % (23, 40 %) and 5 % (2, 11 %) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

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Acknowledgments

This work was supported by National Institute of Health (NIH) grants including the Neurologic AIDS Research Consortium grant NS32228 from NINDS, the AIDS Clinical Trials Grant U01AI068636 from NIAID, and the Statistical and Data Management Center of the Adult AIDS Clinical Trials Group grant 1 U01 068634. The clinical trials registration unique identifier is NCT00001137. The authors acknowledge the generous dedication of the many participants volunteering for the ALLRT study, and for the contributions of the contributing AIDS Clinical Trials Units, their investigators and staffs, that collected the samples and clinical data used for this analysis. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Center for Biostatistics in AIDS Research, Department of Biostatistics, FXB 604B, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA, 02115, USA

    Anthony J. Lee, Ronald J. Bosch, Scott R. Evans & Kunling Wu

  2. Department of Neurology, Emory University School of Medicine, Grady Memorial Hospital, Atlanta, GA, USA

    Taylor Harrison

  3. Department of Medicine-Infectious Disease, Stanford School of Medicine, Stanford, CA, USA

    Philip Grant

  4. Department of Neurology, Washington University, Saint Louis, Mo, USA

    David B. Clifford

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  1. Anthony J. Lee
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  2. Ronald J. Bosch
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  3. Scott R. Evans
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  4. Kunling Wu
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  5. Taylor Harrison
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  6. Philip Grant
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  7. David B. Clifford
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Correspondence to Anthony J. Lee.

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Lee, A.J., Bosch, R.J., Evans, S.R. et al. Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen. J. Neurovirol. 21, 210–218 (2015). https://doi.org/10.1007/s13365-015-0327-1

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  • DOI: https://doi.org/10.1007/s13365-015-0327-1

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