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Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology

  • Animal Genetics • Original Paper
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An Erratum to this article was published on 05 March 2015

Abstract

Newcastle disease (ND) and avian infectious bronchitis (IB) are contagious diseases of chickens. To identify genes associated with antibody levels against ND and IB, a genome-wide association study was performed using specific-locus amplified fragment sequencing (SLAF-seq) technology in Jinghai yellow chickens. This determined six single-nucleotide polymorphisms (SNPs) that were associated with antibody levels against Newcastle disease virus (NDV): rsZ2494661, rsZ2494710, rs1211307701, rs1211307711, rs1218289310 and rs420701988. Of these, rsZ2494661 and rsZ2494710 reached the 5 % Bonferroni genome-wide significance level (5.5E-07) and they were both 134.7 kb downstream of the SETBP1 gene. The remaining four SNPs had ‘suggestive’ genome-wide significance levels (1.1E-05) and they were within or near the Plexin B1, LRRN1 and PDGFC genes. IB had two SNPs associated with antibody levels: rs149988433 and rs16170823; both reached chromosome-wide significance levels and they were near the USP7 and TRIM27 genes, respectively. Bioinformatics, GO annotation and pathway analysis indicated that five of these genes (Plexin B1, TRIM27, PDGFC, SETBP1 and USP7) may be important for the generation of protective antibodies against NDV and infectious bronchitis virus (IBV). This paves the way for further research on host immune responses against NDV.

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Acknowledgements

This work was supported by the Natural Science Foundation of Colleges and Universities in Jiang Su Province, China (12KJB230003), the Natural Science Foundation of China (31201793), the National Poultry Industry Technology System of China (nycytx-42-G1-05), the University Preponderant Discipline Construction Project of Jiang Su Province, China, and the Animal Genetic Breeding and Molecular Design Key Laboratory of Jiang Su Province, China.

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    Authors and Affiliations

    1. College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009, China

      Wenhao Wang, Tao Zhang, Genxi Zhang, Jinyu Wang & Kunpeng Han

    2. Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province, Yangzhou, Jiangsu, 225009, China

      Wenhao Wang, Tao Zhang, Genxi Zhang, Jinyu Wang & Kunpeng Han

    3. Jiangsu Jinghai Industry Poultry Group Co., Ltd., Nantong, Jiangsu, 226103, China

      Yongjuan Wang

    4. Biomarker Technologies Corporation, Beijing, China

      Yinwen Zhang

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    1. Wenhao Wang
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    Correspondence to Jinyu Wang.

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    Communicated by: Maciej Szydlowski

    Wenhao Wang and Tao Zhang contributed equally to this study.

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    Wang, W., Zhang, T., Zhang, G. et al. Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology. J Appl Genetics 56, 365–373 (2015). https://doi.org/10.1007/s13353-014-0269-y

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