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Dispersion profile of a needle-free jet injection depends on the interfacial property of the medium

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Abstract

Injections into or through the skin are common drug or vaccine administration routes, which can be achieved with conventional needles, microneedles, or needle-free jet injections (NFJI). Understanding the transport mechanism of these injected fluids is critical for the development of effective drug administration devices. NFJI devices are distinct from traditional injection techniques by their route and time scale, which relies on a propelled microjet with sufficient energy to penetrate the skin surface and deliver the drug into the targeted region. The injected fluid interacts with multiple skin tissue layers and interfaces, which implies that the corresponding injection profile is dependent on their mechanical properties. In this study, we address the lack of fundamental knowledge on the impact of these interfaces on the injection profiles of NFJI devices.

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The data and materials that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by grants from the National Research Foundation (NRF) (NRF-2019R1A2C2088973) funded by the Ministry of Science & ICT and the Korea Evaluation Institute of Industrial Technology (KEIT) (20011377) funded by the Ministry of Trade, Industry & Energy, Republic of Korea.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Graduate School, Kookmin University, Seoul, 02707, Republic of Korea

    Abdul Mohizin

  2. School of Mechanical Engineering and Department of Integrative Biomedical Science and Engineering, Graduate School, Kookmin University, Seoul, 02707, Republic of Korea

    Jung Kyung Kim

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  1. Abdul Mohizin
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Contributions

Conceptualization: A. Mohizin and J. K. Kim; idea: A. Mohizin and J. K. Kim; funding acquisition: J. K. Kim; project administration: J. K. Kim; experiments and data analysis: A. Mohizin; writing − original draft preparation: A. Mohizin; writing − review and editing: A. Mohizin and J. K. Kim.

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Correspondence to Jung Kyung Kim.

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Mohizin, A., Kim, J. Dispersion profile of a needle-free jet injection depends on the interfacial property of the medium. Drug Deliv. and Transl. Res. 12, 384–394 (2022). https://doi.org/10.1007/s13346-021-01049-7

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