Abstract
Objective
To assess the efficacy of nasal intermittent positive pressure ventilation with heliox in preterm infants with respiratory distress syndrome.
Methods
Premature infants with mild respiratory distress syndrome requiring non-invasive respiratory support were eligible. Infants were randomly assigned to heliox or air-oxygen group. The main outcome was the length of ventilation.
Results
Heliox significantly decreased the length of ventilation. The length of ventilation was positively correlated with interleukin-6 at baseline. Carbon dioxide elimination was better in the heliox group.
Conclusion
Heliox delivered with nasal intermittent positive pressure ventilation may be effective in reducing length of ventilation and increasing carbon dioxide elimination.
Similar content being viewed by others
References
Davis PG, Morley CJ, Owen LS. Non-invasive respiratory support of preterm neonates with respiratory distress: Continuous positive airway pressure and nasal intermittent positive pressure ventilation. Semin Fetal Neonat Med. 2009;14:14–20.
Szczapa T, Gadzinowski J. Use of heliox in the management of neonates with meconium aspiration syndrome. Neonatology. 2011;100:265–70.
Ozima M, Podosek FA. Noble Gas Geochemistry. Cambridge University Press, 2002.
Papamoschou D. Theoretical validation of the respiratory benefits of helium-oxygen mixtures. Resp Physiol. 1995;99:183–90.
Dani C, Fontanelli G, Lori I, Favelli F, Poggi C. Heliox non-invasive ventilation for preventing extubation failure in preterm infants. J Matern-Fetal Neonat Med. 2013;26:603–7.
Elleau C, Galperine R, Guenard H, Demarquez JL. Helium-oxygemixture in respiratory distress syndrome: A double-blind study. J Pediatr. 1993;122:132–6.
Colnaghi M, Pierro M, Migliori C, Ciralli F, Matassa PG, Vendettuoli V, et al. Nasal continuous positive airway pressure with heliox in preterm infants with respiratory distress syndrome. Pediatrics. 2012;129:e333–8.
Chowdhury MM, McKenzie SA, Pearson CC, Carr S, Pao C, Shah AR, et al. Heliox therapy in bronchiolitis: Phase III multicenter double-blind randomized controlled trial. Pediatrics. 2013;131:661–9.
Nawab US, Touch SM, Irwin-Sherman T, Blackson TJ, Greenspan JS, Zhu G, et al. Heliox attenuates lung inflammation and structural alterations in acute lung injury. Pediatr Pulmonal. 2005;40:524–32.
Yilmaz S, Daglioglu K, Yildizdas D, Bayram I, Gumurdulu D, Polat S. The effectiveness of heliox in acute respiratory distress syndrome. Ann Thorac Med. 2013;8:46–52.
Dani C, Fontanelli G, Lori I, Favelli F, Poggi C. Heliox non-invasive ventilation for preventing extubation failure in preterm infants. J Matern-Fetal Neonat Med. 2013;26:603–7.
Migliori C, Gancia P, Garzoli E, Spinoni V, Chirico G. The Effects of helium/oxygen mixture (heliox) before and after extubation in long-term mechanically ventilated very low birth weight infants. Pediatrics. 2009;123:1524–8.
Gupta VK, Cheifetz IM. Heliox administration in the pediatric intensive care unit: an evidence-based review. Pediatr Crit Care Med. 2005;6:204–11.
Abd-Allah SA, Rogers MS, Terry M, Gross M, Perkin RM. Helium-oxygen therapy for pediatric acute severe asthma requiring mechanical ventilation. Pediatr Crit Care Med. 2003;4:353–7.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Li, X., Shen, J., Zhao, J. et al. Nasal intermittent positive pressure ventilation with heliox in premature infants with respiratory distress syndrome: A randomized controlled trial . Indian Pediatr 51, 900–902 (2014). https://doi.org/10.1007/s13312-014-0524-7
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-014-0524-7