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Rituximab followed by mycophenolate mofetil in children with IgM nephropathy

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Abstract

IgM nephropathy presents with refractory nephrotic syndrome and its treatment is a significant challenge for pediatricians. We present two patients with IgM nephropathy and frequently relapsing nephrotic syndrome treated with rituximab and subsequently mycophenolate mofetil. Both showed complete remission, which 24 to 30 months later, was still maintained. The role of mycophenolate mofetil therapy in maintaining remission after successful treatment of rituximab in IgM nephropathy needs to be examined.

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Authors and Affiliations

  1. Department of Nephrology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, 310003, China

    Jin’ai Gu, Yonghui Xia, Jianhua Mao, Haidong Fu & Ai’min Liu

  2. Department of Nephrology, The Children’s Hospital of Zhejiang, University School of Medicine; Key Laboratory of Reproductive Genetics, Ministry of Education; Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, Hangzhou, 310006, Zhejiang Province, China

    Jianhua Mao

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  1. Jin’ai Gu
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  2. Yonghui Xia
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  3. Jianhua Mao
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  4. Haidong Fu
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  5. Ai’min Liu
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Gu, J., Xia, Y., Mao, J. et al. Rituximab followed by mycophenolate mofetil in children with IgM nephropathy. Indian Pediatr 49, 831–833 (2012). https://doi.org/10.1007/s13312-012-0168-4

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  • DOI: https://doi.org/10.1007/s13312-012-0168-4

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