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Modulation of AMPA receptor function by auxiliary subunits

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e-Neuroforum

Abstract

AMPA receptors are ionotropic glutamate receptors that mediate the majority of fast excitatory transmission in the central nervous system. Their function depends not only on the composition of the subunits GluA1-4, but also on the interaction with auxiliary subunits. Several auxiliary subunits have been identified in proteomic analyses over the last years and we are beginning to understand the complex control of these proteins on physiological properties and membrane-transport of AMPA receptors. Auxiliary subunits such as TARPs, cornichons, and CKAMP44 influence receptor localization on the cell membrane, modulate receptor gating, and play a role for synaptic short-term and long-term plasticity.

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Acknowledgments

This work has been funded by the German Research Foundation (DFG) within the Collaborative Research Center (SFB) 1134 “Functional Ensembles” and the Research Grant EN948/1–1. We would like to thank Dagmar Anders from the DKFZ and Eric Jacobi for the generation of the figures.

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Authors and Affiliations

  1. Department of Clinical Neurobiology, Heidelberg University Medical Center and German Cancer Research Center (DKFZ), Heidelberg, Germany

    Hannah Monyer

  2. Synaptic Signalling and Neurodegeneration/A300, German Center for Neurodegenerative Diseases (DZNE) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Jakob von Engelhardt

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Monyer, H., von Engelhardt, J. Modulation of AMPA receptor function by auxiliary subunits. e-Neuroforum 6, 39–48 (2015). https://doi.org/10.1007/s13295-015-0005-z

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