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Overexpression of LncRNA-ROR predicts a poor outcome in gallbladder cancer patients and promotes the tumor cells proliferation, migration, and invasion

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Tumor Biology

Abstract

LncRNA-ROR has been reported to be involved in many kinds of human cancers. However, whether LncRNA-ROR is involved in gallbladder cancer progression remains largely unknown. The objective of this study is to investigate the role of LncRNA-ROR in gallbladder cancer. We found that LncRNA-ROR expression level was upregulated in gallbladder cancer tissues (P < 0.05) and was significantly associated with tumor sizes (P < 0.05) and lymph node metastasis (P < 0.05). High expression of LncRNA-ROR was significantly associated with poor prognosis in gallbladder cancer patients (P < 0.05). Moreover, knockdown of LncRNA-ROR inhibited cell proliferation, migration, and invasion. The epithelial-mesenchymal transition (EMT) phenotype induced by TGF-β1 was reversed after LncRNA-ROR knocking down in SGC-996 and Noz cells. LncRNA-ROR plays an important role in the development of gallbladder cancer and mediates the EMT in gallbladder cancer. LncRNA-ROR might act as a marker of prognosis and therapeutic target for gallbladder cancer.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant number 81272747 and 81572297) and Doctorial innovation funds of Shanghai Jiao Tong University School of Medicine. We thank Dr. QIU LEI, helped us with language editing.

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Authors and Affiliations

  1. Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200000, China

    Shou-Hua Wang, Ming-Di Zhang, Xiao-Cai Wu, Ming-Zhe Weng, Di Zhou & Zhi-Wei Quan

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  1. Shou-Hua Wang
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  2. Ming-Di Zhang
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  3. Xiao-Cai Wu
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  4. Ming-Zhe Weng
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Correspondence to Zhi-Wei Quan.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Human Ethics Committee of Xinhua Hospital at Shanghai Jiao tong University (Shanghai, China).

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Wang, SH., Zhang, MD., Wu, XC. et al. Overexpression of LncRNA-ROR predicts a poor outcome in gallbladder cancer patients and promotes the tumor cells proliferation, migration, and invasion. Tumor Biol. 37, 12867–12875 (2016). https://doi.org/10.1007/s13277-016-5210-z

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  • DOI: https://doi.org/10.1007/s13277-016-5210-z

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