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Hemocompatibility of folic-acid-conjugated amphiphilic PEG-PLGA copolymer nanoparticles for co-delivery of cisplatin and paclitaxel: treatment effects for non-small-cell lung cancer

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Tumor Biology

Abstract

In this study, we used folic-acid-modified poly(ethylene glycol)-poly(lactic-co-glycolic acid) (FA-PEG-PLGA) to encapsulate cisplatin and paclitaxel (separately or together), and evaluated their antitumor effects against lung cancer; this study was conducted in order to investigate the antitumor effects of the co-delivery of cisplatin and paclitaxel by a targeted drug delivery system. Blood compatibility assays and complement activation tests revealed that FA-PEG-PLGA nanoparticles did not induce blood hemolysis, blood clotting, or complement activation. The results also indicated that FA-PEG-PLGA nanoparticles had no biotoxic effects, the drug delivery system allowed controlled release of the cargo molecules, and the co-delivery of cisplatin and paclitaxel efficiently induces cancer cell apoptosis and cell cycle retardation. In addition, co-delivery of cisplatin and paclitaxel showed the ability to suppress xenograft lung cancer growth and prolong the survival time of xenografted mice. These results implied that FA-PEG-PLGA nanoparticles can function as effective carriers of cisplatin and paclitaxel, and that co-delivery of cisplatin and paclitaxel by FA-PEG-PLGA nanoparticles results in more effective antitumor effects than the combination of free-drugs or single-drug-loaded nanoparticles.

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Authors and Affiliations

  1. The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan Western Road, Wenzhou, 325027, China

    Zelai He, Wenjun Chen & Jingwen Huang

  2. Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China

    Xiangyu Zhang

  3. Department of Ultrasound, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China

    Jing Ma

  4. Department of Nuclear Medicine, the Affiliated Provincial Hospital of Anhui Medical University, Hefei, 230001, China

    Junyong Xia

  5. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Zelai He & Wenjie Sun

  6. Henan Polytechnic Institute, No 666, Kongming North Road, Nanyang Henan, 473000, China

    Zengfang Shi

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  1. Zelai He
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Correspondence to Xiangyu Zhang, Wenjun Chen or Jingwen Huang.

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He, Z., Shi, Z., Sun, W. et al. Hemocompatibility of folic-acid-conjugated amphiphilic PEG-PLGA copolymer nanoparticles for co-delivery of cisplatin and paclitaxel: treatment effects for non-small-cell lung cancer. Tumor Biol. 37, 7809–7821 (2016). https://doi.org/10.1007/s13277-015-4634-1

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  • DOI: https://doi.org/10.1007/s13277-015-4634-1

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