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The roles of microRNAs in Wilms’ tumors

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Tumor Biology

Abstract

Wilms’ tumor is the most common renal tumor in children in which diffusely anaplastic or unfavorable histology foreshadows poor prognosis. MicroRNAs are small, non-coding RNAs that negatively regulate gene expression at the posttranscriptional level. Accumulating evidence shows that microRNA dysregulation takes part in the pathogenesis of many renal diseases, such as chronic kidney diseases, polycystic kidney disease, renal fibrosis, and renal cancers. In Wilms’ tumor, dysregulation of some key oncogenic or tumor-suppressing microRNAs, such as miR-17~92 cluster, miR-185, miR-204, and miR-483, has been documented. In this review, we will summarize current evidence on the role of dysregulated microRNAs in the development of Wilms’ tumor.

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    Authors and Affiliations

    1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100042, China

      Xin Yu

    2. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100042, China

      Zheng Li

    3. Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China

      Matthew T V Chan & William Ka Kei Wu

    4. State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China

      William Ka Kei Wu

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    1. Xin Yu
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    Correspondence to Zheng Li.

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    Xin Yu and Zheng Li contributed equally to this work.

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    Yu, X., Li, Z., Chan, M.T.V. et al. The roles of microRNAs in Wilms’ tumors. Tumor Biol. 37, 1445–1450 (2016). https://doi.org/10.1007/s13277-015-4514-8

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