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Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer

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Tumor Biology

Abstract

There is increasing evidence suggesting that establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) was involved in tumorigenesis. However, its role in bladder cancer remains unclear. In this study, we aimed to study the clinical correlation and biological significance of ESCO1 in bladder cancer. Our results showed that ESCO1 was significantly over-expressed in bladder cancer tissues compared with that in adjacent normal tissues. And, increased ESCO1 expression was significantly associated with higher grade (P < 0.001), higher tumor stage (P = 0.014), and multifocality (P = 0.042). Kaplan–Meier analysis and Cox proportional hazards model were performed to determine the prognostic significance of ESCO1, and the results showed that ESCO1 is a useful prognostic marker for bladder cancer patients. Moreover, we found that ESCO1 knockdown inhibited the growth, migration, and invasion of bladder cancer cells. In conclusion, our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer.

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Acknowledgments

The authors thank all patients and people who had participated in this research.

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Authors and Affiliations

  1. Department of Urology, Air Force General Hospital of PLA, 30 Fucheng Road, Haidian Distinct, Beijing, 100142, China

    Shiying Zhang, Jianye Li, Gaobiao Zhou, Dawei Mu, Jingmin Yan, Jizhang Xing, Zhiyong Yao, Haibo Sheng, Di Li, Chao Lv, Bin Sun, Quan Hong & Heqing Guo

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  1. Shiying Zhang
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  2. Jianye Li
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  3. Gaobiao Zhou
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  4. Dawei Mu
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  5. Jingmin Yan
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  6. Jizhang Xing
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  7. Zhiyong Yao
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  8. Haibo Sheng
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  9. Di Li
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  12. Quan Hong
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  13. Heqing Guo
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Correspondence to Heqing Guo.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Zhang, S., Li, J., Zhou, G. et al. Increased expression of ESCO1 is correlated with poor patient survival and its role in human bladder cancer. Tumor Biol. 37, 5165–5170 (2016). https://doi.org/10.1007/s13277-015-4375-1

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  • DOI: https://doi.org/10.1007/s13277-015-4375-1

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