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Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling

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Tumor Biology

Abstract

Histone deacetylases (HDACs) play a role in the tumorigenesis of glioblastoma multiforme (GBM), whereas the underlying mechanism has not been elucidated. Here, we reported significantly higher HDAC6 levels in GBM from the patients. GBM cell growth was significantly inhibited by ACY-1215, a specific HDAC6 inhibitor. Further analyses show that HDAC6 may promote growth of GBM cells through inhibition of SMAD2 phosphorylation to downregulate p21. Thus, our data demonstrate a previously unrecognized regulation pathway in that HDAC6 increases GBM growth through attenuating transforming growth factor β (TGFβ) receptor signaling.

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Authors and Affiliations

  1. Department of Neurosurgery, Zhujiang Hospital, The National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou, 510282, China

    Shun Li, Xiao Liu & Xiangyu Wang

  2. Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China

    Shun Li

  3. Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China

    Xiangrong Chen

  4. Department of Neurosurgery, The First Affiliated Hospital of Jinan University, 613 West Huangpu Road, Guangzhou, 510630, China

    Liu Zhang & Xiangyu Wang

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  1. Shun Li
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  2. Xiao Liu
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  3. Xiangrong Chen
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  4. Liu Zhang
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  5. Xiangyu Wang
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Corresponding author

Correspondence to Xiangyu Wang.

Additional information

Shun Li and Xiao Liu contributed equally to this work.

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Li, S., Liu, X., Chen, X. et al. Histone deacetylase 6 promotes growth of glioblastoma through inhibition of SMAD2 signaling. Tumor Biol. 36, 9661–9665 (2015). https://doi.org/10.1007/s13277-015-3747-x

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  • DOI: https://doi.org/10.1007/s13277-015-3747-x

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