Abstract
Previous studies have showed that ABO blood type is associated with multiple gastrointestinal cancers, including pancreatic cancer. Recently, one single nucleotide polymorphism (SNP) rs505922 in ABO gene has been implicated in susceptibility to pancreatic cancer across different populations, but different results were found in other types of cancer. This meta-analysis aimed to clarify the association. All eligible case–control studies were identified by searching through PubMed and Chinese language databases (CNKI and WanFang) up to September 1, 2014. Pooled estimates (odds ratio) were used to assess the strength of associations in fixed- or random-effects models. A total of nine studies with 10,304 cases and 15,564 controls were included. Overall, SNP rs505922 C allele was confirmed as a risk factor for cancer. Additionally, in further stratified analysis by cancer type, C allele carriers were more likely to have higher risk of pancreatic cancer. This study provided evidence of SNP rs505922 C allele as a strong risk factor of cancer susceptibility, specifically for pancreatic cancer.
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This work was funded by grants from the Jiangsu Health International Exchange Supporting Program provided by Xiao-Dong Li.
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YFD, FZ, and XDL carried out the literature collection and screening. YFD, FZ, XDL, YA, and HZ participated in the design of the study and performed the meta-analysis. YFD, FZ, and XDL drafted the manuscript. YZ and XZ helped to edit the manuscript. YJ conceived of the study and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
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Drs. Yun-Fei Duan, Feng Zhu, and Xiao-Dong Li contributed equally to this article and share the first authorship.
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Duan, YF., Zhu, F., Li, XD. et al. Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis. Tumor Biol. 36, 5081–5087 (2015). https://doi.org/10.1007/s13277-015-3159-y
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DOI: https://doi.org/10.1007/s13277-015-3159-y