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Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

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Tumor Biology

Abstract

The aim of this study was to determine levels of serum 8-hydroxy-2′-deoxyguanosine (8-OHdG) as an indicator of oxidant-induced DNA damage and oxidant status in patients with papillary thyroid carcinoma before and after surgery. This study included 25 patients with papillary thyroid carcinoma and age-matched 27 healthy controls. Total antioxidant status (TAS), total oxidant status (TOS), lipid hydroperoxide (LOOH), and 8-OHdG levels were measured. 8-OHdG levels were significantly higher in the preoperative papillary thyroid carcinoma (PTC) group compared with the healthy control group (p < 0.001) and were significantly lower after operation in patients with papillary thyroid carcinoma (p = 0.004). Oxidative stress index (OSI) levels were significantly higher in both preoperative and postoperative PTC patients compared with the healthy control group (p < 0.001 and p < 0.001, respectively). TOS levels were higher in the preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). TAS levels was lower in the preoperative PTC groups compared to the healthy control group (p = 0.011). Serum LOOH levels were higher in both preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). Correlation analysis yielded that serum 8-OHdG levels were positively correlated with OSİ and LOOH levels in patients with PTC before surgery (r = 0.668, p < 0.001; r = 0.446, p = 0.025, respectively) and had a negative correlation with TAS levels (r = −0.616, p = 0.001). We have shown severe oxidative DNA damage and impaired antioxidant status in papillary thyroid carcinoma.

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Authors and Affiliations

  1. Department of Endocrinology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

    Suzan Tabur, Hakan Korkmaz, Mesut Ozkaya & Ersin Akarsu

  2. Department of Biochemistry, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

    Şefika Nur Aksoy

  3. Department of Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey

    Nurten Aksoy

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  1. Suzan Tabur
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  2. Şefika Nur Aksoy
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  3. Hakan Korkmaz
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Correspondence to Suzan Tabur.

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Tabur, S., Aksoy, Ş.N., Korkmaz, H. et al. Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma. Tumor Biol. 36, 2667–2674 (2015). https://doi.org/10.1007/s13277-014-2889-6

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  • DOI: https://doi.org/10.1007/s13277-014-2889-6

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