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Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer

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Tumor Biology

Abstract

Different long non-coding RNAs (lncRNAs) are transcribed within the genome. Although initially argued to be spurious transcriptional noise, these RNAs play important roles in biological pathways, as shown by different studies. Also, there are some reports about the role of lncRNAs in different cancers. They can contribute to the development and progression of cancer by the functioning as oncogene or/and tumor suppressor molecules. In this review, we point to some important lncRNAs as examples which seem to be involved in cancer initiation/progression.

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Acknowledgments

This work was supported by a grant of National Research Foundation of Korea (NRF) grant for the Global Core Research Center (GCRC) funded by the Ministry of Science, ICT & Future Planning (MSIP) (No.2011-0030001). The research was also supported by Shahid Chamran University of Ahvaz in Iran.

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Authors and Affiliations

  1. Department of Genetics, Shahid Chamran University of Ahvaz, Ahvaz, Iran

    Mohammadreza Hajjari

  2. Laboratory of Molecular Pathology and Cancer Genomics, Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, South Korea

    Atefeh Khoshnevisan & Young Kee Shin

  3. Tumor Microenvironment Global Core Research Center, Seoul National University, Seoul, South Korea

    Young Kee Shin

  4. Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul, South Korea

    Young Kee Shin

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  1. Mohammadreza Hajjari
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Hajjari, M., Khoshnevisan, A. & Shin, Y.K. Molecular function and regulation of long non-coding RNAs: paradigms with potential roles in cancer. Tumor Biol. 35, 10645–10663 (2014). https://doi.org/10.1007/s13277-014-2636-z

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