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RETRACTED ARTICLE: Pttg1 inhibits TGFβ signaling in breast cancer cells to promote their growth

  • Research Article
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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Increased expression of Pituitary Tumor Transforming Gene 1 (Pttg1) has been shown in various tumor cells, including breast cancer (BC). However, the precise role of Pttg1 in the tumorigenesis is not clarified yet. Here, we examined BC from the patients and detected significant increases and correlation in Pttg1 and phosphorylated SMAD3 (pSMAD3), a key effector of activated transforming growth factor β (TGFβ) receptor signaling pathway. Pttg1 levels were then modulated by transgene or small hairpin RNA (shRNA) in a human BC cell line, BT474, respectively. We found that Pttg1 overexpression increased the proliferation of BC cells in vitro and in vivo, while Pttg1 inhibition decreased proliferation of BC cells in vitro and in vivo. Moreover, phosphorylation of SMAD3 by TGFβ1 was significantly inhibited by Pttg1 overexpression, suggesting that Pttg1 may promote growth of BC cells by inhibiting pSMAD3-mediated cell-growth inhibition. Thus, Pttg1 appears to be a novel therapeutic target for controlling the tumorigenesis of BC.

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Authors and Affiliations

  1. Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, 200065, Shanghai, China

    Guofeng Zhang, Songlin Yu & Rui Lin

  2. Department of Oncology, Tongji Hospital, Tongji University School of Medicine, 200065, Shanghai, China

    Qicheng Zhao

  3. Department of Pathology, Tongji Hospital, Tongji University School of Medicine, 200065, Shanghai, China

    Xianghua Yi

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  1. Guofeng Zhang
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  2. Qicheng Zhao
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  3. Songlin Yu
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  4. Rui Lin
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  5. Xianghua Yi
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Corresponding authors

Correspondence to Guofeng Zhang or Xianghua Yi.

Additional information

Guofeng Zhang and Qicheng Zhao equally contributed to this work.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Zhang, G., Zhao, Q., Yu, S. et al. RETRACTED ARTICLE: Pttg1 inhibits TGFβ signaling in breast cancer cells to promote their growth. Tumor Biol. 36, 199–203 (2015). https://doi.org/10.1007/s13277-014-2609-2

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  • DOI: https://doi.org/10.1007/s13277-014-2609-2

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