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Serum albumin as a significant prognostic factor in patients with malignant pleural mesothelioma

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Tumor Biology

Abstract

Our aim was to evaluate the prognostic role of the pretreatment serum albumin level in patients with malignant pleural mesothelioma (MPM) receiving platinum-based systemic chemotherapy. From 1995 to 2013, a total of 97 patients receiving platinum-based systemic chemotherapy for newly diagnosed MPM were enrolled. All clinical information and laboratory results were retrospectively collected from the medical records. The Kaplan–Meier method was used to calculate survival. The Cox proportional hazards model was used to identify significant independent prognostic factors for predicting survival. In total, 34 of the 97 patients (35.1 %) had hypoalbuminaemia (albumin ≤35 g/l). The 1-year overall survival rate was 44.1 % for patients with hypoalbuminaemia and 72.0 % for patients with a normal albumin level. Multivariate analysis indicated that pretreatment albumin was an independent prognostic factor in MPM. Patients with hypoalbuminaemia had a greater risk of death than those with a normal albumin level [hazard ratio (HR) 1.778; 95 % confidence interval (CI) 1.504–2.998; P = 0.031]. When albumin was entered as a continuous variable in the Cox regression model, the HR of death was significantly decreased by 9.8 % (95 % CI 0.851–0.956) for each 1-g/l increment. The pretreatment serum albumin level is a simple, inexpensive and easily measurable marker with prognostic significance in MPM patients treated with platinum-based systemic chemotherapy.

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Acknowledgments

We thank the staff at the Department of Respiratory Medicine of Qilu Hospital and of Shandong Provincial Hospital Affiliated to Shandong University as well as the staff at the Department of Tuberculosis Medicine of Shandong Provincial Chest Hospital for their assistance in collecting clinical data.

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None.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, No. 324 Jingwuweiqi Road, Jinan, Shandong Province, 250021, People’s Republic of China

    Zhou-Hong Yao, Yun-Yan Wan, Qing-Hua Liu & Dian-Jie Lin

  2. Department of Neurology, Qilu Children’s Hospital of Shandong University, Jinan, Shandong Province, 250021, People’s Republic of China

    Guang-Yan Tian

  3. Department of Medical Care for Personnel, Jinan Central Hospital, Jinan, Shandong Province, 250031, People’s Republic of China

    Shao-Xiang Yang

  4. Department of Respiratory Medicine, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, 250014, People’s Republic of China

    Yan-Meng Kang

  5. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong Province, 250021, People’s Republic of China

    Fei Yao

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  1. Zhou-Hong Yao
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Correspondence to Dian-Jie Lin.

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Yao, ZH., Tian, GY., Yang, SX. et al. Serum albumin as a significant prognostic factor in patients with malignant pleural mesothelioma. Tumor Biol. 35, 6839–6845 (2014). https://doi.org/10.1007/s13277-014-1938-5

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  • DOI: https://doi.org/10.1007/s13277-014-1938-5

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