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The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis

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Tumor Biology

Abstract

Emerging evidences show that interleukin-8 (IL-8) has important regulatory functions in tumorigenesis. IL-8 -251A/T is a single nucleotide polymorphism in the promoter region of the IL-8 gene and affects IL-8 production. Analysis of previous studies on the association of -251A/T polymorphism with different cancer types remained to be illustrated. To further assess the effect of -251A/T polymorphism on cancer risks, we performed this meta-analysis, up to November 2013, of 12,917 cases with different cancer types and 17,689 controls from 47 published case-control designed studies. Statistical analyses were performed using STATA 11.0 software. Crude odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. ORs with 95 % CIs for IL-8 -251A/T polymorphism and cancer were estimated using fixed- and random-effects models when appropriate. Significantly increased risks were found in overall under the models of A allele vs. T allele, AA vs. TT, and AA vs. AT/TT. Significantly elevated risks were observed in breast cancer under the models of A allele vs. T allele, AT vs. TT, AA/AT vs. TT, and AA vs. AT/TT, and in nasopharyngeal carcinoma under the models of AT vs. TT, AA/AT vs. TT, and AA vs. AT/TT. We found that significantly elevated risks were observed in the Asian population and hospital-based studies in all comparison models. Thus, this meta-analysis indicates that IL-8 -251A/T polymorphism is associated with a significantly increased risk of cancers and may provide evidence-based medical certificate to study the cancer susceptibility.

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Acknowledgments

We thank Dr. Xiaofeng Wang for her critical comments of this manuscript.

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Authors and Affiliations

  1. Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China

    Ziliang Wang, Lina Yang & Gong Yang

  2. Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

    Yang Liu, Sheng Yin & Rongyu Zang

  3. Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong’an Road, Shanghai, 200032, China

    Ziliang Wang, Yang Liu, Lina Yang, Sheng Yin, Rongyu Zang & Gong Yang

  4. Central Laboratory, the Fifth People’s Hospital of Shanghai, Fudan University, 128 Ruili Road, Shanghai, 200240, China

    Gong Yang

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  1. Ziliang Wang
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  2. Yang Liu
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Correspondence to Rongyu Zang or Gong Yang.

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Wang, Z., Liu, Y., Yang, L. et al. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis. Tumor Biol. 35, 7115–7123 (2014). https://doi.org/10.1007/s13277-014-1881-5

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  • DOI: https://doi.org/10.1007/s13277-014-1881-5

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