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Association between glutathione S-transferase T1 null genotype and glioma susceptibility: a meta-analysis

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Tumor Biology

Abstract

The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However, these studies report inconsistent results. In order to get this precise result, a meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95 % confidence intervals (95 % CI). Eleven case–control research studies with a total of 2,416 glioma cases and 4,850 controls were included into this meta-analysis. The combined results based on all studies showed that there was no significant association between the GSTT1 null allele and glioma risk (OR = 1.188, 95 % CI = 0.929–1.520, P heterogeneity = 0.003, P = 0.170). In the subgroup analysis, the same results were found in our work. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null genotype was not associated with the increased risk of glioma.

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Authors and Affiliations

  1. Department of Neurology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, 150086, China

    Benping Zhang, Jianjiao Wang, Yang Li, Fei Yuan, Yu Tian, Fenggang Zhou, Zhen Hao, Yongri Zheng, Qingsong Li & Weizhi Wang

  2. Department of Emergency, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, 150086, China

    Hongshuang Niu

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  1. Benping Zhang
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  2. Jianjiao Wang
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  3. Hongshuang Niu
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  4. Yang Li
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  5. Fei Yuan
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  6. Yu Tian
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  7. Fenggang Zhou
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  9. Yongri Zheng
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  10. Qingsong Li
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  11. Weizhi Wang
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Correspondence to Qingsong Li or Weizhi Wang.

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Zhang, B., Wang, J., Niu, H. et al. Association between glutathione S-transferase T1 null genotype and glioma susceptibility: a meta-analysis. Tumor Biol. 35, 2081–2086 (2014). https://doi.org/10.1007/s13277-013-1276-z

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  • DOI: https://doi.org/10.1007/s13277-013-1276-z

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