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Effect of Euphorbia humifusa Willd extract on the amelioration of innate immune responses

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Abstract

Euphorbia humifusa Willd is an annual plant widely used as a vegetable and traditional medicinal herb. E. humifusa Willd displays a variety of pharmacological actions; however, the effect of E. humifusa Willd on the innate immune response has not been well characterized. The aim of this study is to investigate the effect of an E. humifusa Willd methanolic extract (EuH) on the activation of innate immune cells. Here, we found that the EuH increased the expression of the innate cytokines, TNFα and IL-1β, in THP-1 monocytes and THP-1-derived macrophages. In addition, the EuH enhanced the phagocytosis of THP-1-derived macrophages. These findings suggest that E. humifusa Willd may be helpful for preventing bacterial infection and could be developed as a dietary supplement for ameliorating innate immune response.

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Acknowledgments

This study was supported by the Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01188402; Rural Development Administration), Republic of Korea. This paper was supported by the KU Research Professor Program of Konkuk University.

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Authors and Affiliations

  1. Cancer and Metabolism Institute, Konkuk University, Seoul, 05029, Republic of Korea

    Chang Gun Kim, Young Han Lee & Soon Young Shin

  2. Division of Bioscience and Biotechnology, College of Biological Science and Biotechnology, BMIC, Konkuk University, Seoul, 05029, Republic of Korea

    Yoongho Lim

  3. Department of Biological Sciences, College of Biological Science and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05029, Republic of Korea

    Young Han Lee & Soon Young Shin

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  1. Chang Gun Kim
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  2. Yoongho Lim
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Correspondence to Soon Young Shin.

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Chang Gun Kim declares that he/she has no conflict of interest. Yoongho Lim declares that he/she has no conflict of interest. Young Han Lee declares that he/she has no conflict of interest. Soon Young Shin declares that he/she has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Kim, C.G., Lim, Y., Lee, Y.H. et al. Effect of Euphorbia humifusa Willd extract on the amelioration of innate immune responses. Genes Genom 38, 999–1004 (2016). https://doi.org/10.1007/s13258-016-0444-0

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  • DOI: https://doi.org/10.1007/s13258-016-0444-0

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