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A comparative, BAC end sequence enabled map of the genome of the American mink (Neovison vison)

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Abstract

In this report we present the results of the analysis of approximately 2.7 Mb of genomic information for the American mink (Neovison vison) derived through BAC end sequencing. Our study, which encompasses approximately 1/1000th of the mink genome, suggests that simple sequence repeats (SSRs) are less common in the mink than in the human genome, whereas the average GC content of the mink genome is slightly higher than that of its human counterpart. The 2.7 Mb mink genomic dataset also contained 2,416 repeat elements (retroids and DNA transposons) occupying almost 31% of the sequence space. Among repeat elements, LINEs were over-represented and endogenous viruses (aka LTRs) under-represented in comparison to the human genome. Finally, we present a virtual map of the mink genome constructed with reference to the human and canine genome assemblies using a comparative genomics approach and incorporating over 200 mink BESs with unique hits to the human genome.

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Authors and Affiliations

  1. Department of Plant and Animal Sciences, Nova Scotia Agricultural College, P.O. Box 550, Truro, Nova Scotia, Canada, B2N 5E3

    Bernhard F. Benkel, Amanda Smith & Hossain Farid

  2. Dept. of Animal and Veterinary Basic Sciences, Division of Animal Genetics and Bioinformatics, University of Copenhagen, Groennegaardsvej 3, 1870, Frederiksberg C, Denmark

    Knud Christensen & Razvan Anistoroaei

  3. Faculty of Medicine, Department of Biochemistry & Molecular Biology, University of Calgary, 3330 Hospital Drive N.W., HSC 1150, Calgary, Alberta, Canada, T2N 4N1

    Ye Zhang & Christoph W. Sensen

  4. Lethbridge Research Centre, Agriculture and Agri-Food Canada, P.O. Box 3000, Lethbridge, Alberta, Canada, T1J 4B1

    Lyn Paterson & Ronald M. Teather

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  1. Bernhard F. Benkel
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  2. Amanda Smith
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  3. Knud Christensen
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  4. Razvan Anistoroaei
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  5. Ye Zhang
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  6. Christoph W. Sensen
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  7. Hossain Farid
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  8. Lyn Paterson
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  9. Ronald M. Teather
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Correspondence to Bernhard F. Benkel.

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Benkel, B.F., Smith, A., Christensen, K. et al. A comparative, BAC end sequence enabled map of the genome of the American mink (Neovison vison). Genes Genom 34, 83–91 (2012). https://doi.org/10.1007/s13258-011-0160-8

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  • DOI: https://doi.org/10.1007/s13258-011-0160-8

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