Skip to main content
SpringerLink
Log in

pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate

  • Article
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

The release of mesalazine, an anti-inflammatory drug for Crohn’s disease, should be deferred while delivering along the gastrointestinal tract to maximize drug absorption in the colon. To that end, we intercalated mesalazine into a clay mineral, montmorillonite (MMT), and we encapsulated the resulting composite inside a pHsensitive polymer, an alginate hydrogel bead. Once intercalated between the microscopic MMT layers, the mesalazine is prevented from dissolution during encapsulation into the alginate beads. As the resulting mesalazine-clay-alginate (MCA) bead is covered with a protective alginate layer, the mesalazine does not dissolve in acidic gastric conditions. In in vitro release tests, the MCA beads exhibited less than 5% mesalazine release in gastric solution, while ~20% was released over 7 h in the intestinal condition. Our results demonstrate that the MCA bead is a highly effective, biocompatible means of mesalazine delivery to the colon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. Aguzzi, P. Capra, C. Bonferoni, P. Cerezo, I. Salcedo, R. Sánchez, C. Caramella, and C. Viseras, Appl. Clay Sci., 50, 106 (2010).

    Article  CAS  Google Scholar 

  2. P. H. Layer, H. Goebell, J. Keller, A. Dignass, and U. Klotz, Gastroenterology, 108, 1427 (1995).

    Article  CAS  Google Scholar 

  3. W. S. Omwancha, R. Mallipeddi, B. L. Valle, and S. H. Neau, Int. J. Pharm., 441, 343 (2013).

    Article  CAS  Google Scholar 

  4. J.-H. Yang, J.-H. Lee, H.-J. Ryu, A. A. Elzatahry, Z. A. Alothman, and J.-H. Choy, Appl. Clay Sci., 130, 20 (2016).

    Article  CAS  Google Scholar 

  5. L. A. D. S. Rodrigues, A. Figueiras, F. Veiga, R. M. de Freitas, L. C. C. Nunes, E. C. da Silva Filho, and C. M. da Silva Leite, Colloids Surf. B: Biointerfaces, 103, 642 (2013).

    Article  CAS  Google Scholar 

  6. S. Jayrajsinh, G. Shankar, Y.K. Agrawal, and L. Bakre, J. Drug Deliv. Sci. Technol., 39, 200 (2017).

    Article  CAS  Google Scholar 

  7. H. Khalil, D. Mahajan, and M. Rafailovich, Polym. Int., 54, 423 (2005).

    Article  CAS  Google Scholar 

  8. J. K. Park, Y. B. Choy, J.-M. Oh, J. Y. Kim, S.-J. Hwang, and J.-H. Choy, Int. J. Pharm., 359, 198 (2008).

    Article  CAS  Google Scholar 

  9. G. V. Joshi, B. D. Kevadiya, H. A. Patel, H. C. Bajaj, and R. V. Jasra, Int. J. Pharm., 374, 53 (2009).

    Article  CAS  Google Scholar 

  10. D. Song, S.-J. Park, H. W. Kang, S. B. Park, and J.-I. Han, J. Chem. Eng. Data, 58, 2455 (2013).

    Article  CAS  Google Scholar 

  11. F. Tuğcu-Demiröz, F. Acartürk, S. Takka, and Ö. Konuş-Boyunağa, Eur. J. Pharm. Biopharm., 67, 491 (2007).

    Article  Google Scholar 

  12. Y.-H. Lin, H.-F. Liang, C.-K. Chung, M.-C. Chen, and H.-W. Sung, Biomaterials, 26, 2105 (2005).

    Article  CAS  Google Scholar 

  13. L. N. M. Ribeiro, A. C. S. Alcântara, M. Darder, P. Aranda, F. M. Araújo-Moreira, and E. Ruiz-Hitzky, Int. J. Pharm., 463, 1 (2014).

    Article  CAS  Google Scholar 

  14. L. Neufeld and H. Bianco-Peled, Int. J. Pharm., 491, 170 (2015).

    Article  CAS  Google Scholar 

  15. C. O. Ijagbemi, M.-H. Baek, and D.-S. Kim, J. Hazard. Mater., 166, 538 (2009).

    Article  CAS  Google Scholar 

  16. H. Allgayer, J. Sonnenbichler, W. Kruis, and G. Paumgartner, Arzneimittelforschung, 35, 1457 (1985).

    CAS  Google Scholar 

  17. M. Y. Nassar, M. F. El-Shahat, S. M. Khalile, M. El-Desawy, and E. A. Mohamed, J. Therm. Anal. Calorim., 117, 463 (2014).

    Article  CAS  Google Scholar 

  18. D. Hou, S. Hu, Y. Huang, R. Gui, L. Zhang, Q. Tao, C. Zhang, S. Tian, S. Komarneni, and Q. Ping, Appl. Clay Sci., 119, 277 (2016).

    Article  CAS  Google Scholar 

  19. G. V. J. Bhavesh D. Kevadiya, Hasmukh A. Patel, Pravin G. Ingole, H. M. Mody, and H. C. Bajaj, J. Biomater. Appl., 25, 161 (2010).

    Article  Google Scholar 

  20. S. B. A. M. Zorica, P. Tomić, B. M. Babić, V. A. Poharc Logar, A. R. Đorđević, and S. B. Cupać, J. Agr. Sci., 56, 25 (2011).

    Article  Google Scholar 

  21. T. Pongjanyakul and T. Rongthong, Carbohydr. Polym., 81, 409 (2010).

    Article  CAS  Google Scholar 

  22. T. Østberg and C. Graffner, Int. J. Pharm., 111, 271 (1994).

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the Basic Research Project of the Korea Institute of Geoscience and Mineral Resources (KIGAM) funded by the Ministry of Science, ICT and Future Planning of Korea.

Author information

Authors and Affiliations

  1. Mineral Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon, 34132, Korea

    Hye-Jin Hong, Jiwoong Kim & Yong Jae Suh

  2. NT-IT, Korea University of Science and Technology, Daejeon, 34113, Korea

    Daeyoung Kim

  3. Advanced Geo-Materials Research Department, Korea Institute of Geoscience and Mineral Resources (KIGAM), Daejeon, 34132, Korea

    Ki-Min Roh & Ilmo Kang

Authors
  1. Hye-Jin Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiwoong Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yong Jae Suh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daeyoung Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ki-Min Roh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ilmo Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Hye-Jin Hong or Ilmo Kang.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hong, HJ., Kim, J., Suh, Y.J. et al. pH-sensitive mesalazine carrier for colon-targeted drug delivery: A two-fold composition of mesalazine with a clay and alginate. Macromol. Res. 25, 1145–1152 (2017). https://doi.org/10.1007/s13233-017-5150-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-017-5150-5

Keywords

Search

Navigation